
Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific
Danielle
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The Asian Mouse Mutagenesis Useful resource Affiliation (AMMRA) is a non-profit group consisting of main useful resource and analysis establishments with rodent experience from inside the Asia Pacific area.
For greater than a decade, aiming to assist biomedical analysis and stimulate worldwide collaboration, AMMRA has all the time been a pleasant and passionate ally of Asian and Australian member establishments dedicated to sharing information, exchanging sources, and selling biomedical analysis. AMMRA can be missioned to world connection by working carefully with the consortiums such because the Worldwide Mouse Phenotyping Consortium and the Worldwide Mouse Pressure Useful resource.
This evaluate discusses the emergence of AMMRA and descriptions its many roles and duties in selling, helping, enriching analysis, and in the end enhancing world life science analysis high quality.
Genetic discount of mTOR extends lifespan in a mouse mannequin of Hutchinson-Gilford Progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a uncommon accelerated ageing dysfunction most notably characterised by heart problems and untimely demise from myocardial infarction or stroke.
The vast majority of circumstances are attributable to a de novo single nucleotide mutation within the LMNA gene that prompts a cryptic splice donor web site, leading to manufacturing of a poisonous type of lamin A with a 50 amino acid inner deletion, termed progerin.
We beforehand reported the era of a transgenic murine mannequin of progeria carrying a human BAC harboring the frequent mutation, G608G, which within the single-copy state develops options of HGPS which might be restricted to the vascular system. Right here, we report the phenotype of mice bred to hold two copies of the BAC, which extra utterly recapitulate the phenotypic options of HGPS in pores and skin, adipose, skeletal, and vascular tissues.
We additional present that genetic discount of the mechanistic goal of rapamycin (mTOR) considerably extends lifespan in these mice, offering a rationale for pharmacologic inhibition of the mTOR pathway within the therapy of HGPS.
Mental Incapacity and Mind Creatine Deficit: Phenotyping of the Genetic Mouse Mannequin for GAMT Deficiency
Guanidinoacetate methyltransferase deficiency (GAMT-D) is one in every of three cerebral creatine (Cr) deficiency syndromes attributable to pathogenic variants within the GAMT gene (19p13.3). GAMT-D is characterised by the buildup of guanidinoacetic acid (GAA) and the depletion of Cr, which end in extreme world developmental delay (and mental incapacity), motion dysfunction, and epilepsy.
The GAMT knockout (KO) mouse mannequin presents biochemical alterations in bodily fluids, the mind, and muscle tissue, together with elevated GAA and decreased Cr and creatinine (Crn) ranges, that are just like these noticed in people.
On the behavioral stage, solely restricted and gentle alterations have been reported, with a big a part of analyzed behaviors being unaffected in GAMT KO as in contrast with wild-type mice. On the cerebral stage, decreased Cr and Crn and elevated GAA and different guanidine compound ranges have been noticed. However, the consequences of Cr deficiency and GAA accumulation on many neurochemical, morphological, and molecular processes haven’t but been explored.
On this evaluate, we summarize information concerning behavioral and cerebral GAMT KO phenotypes, and deal with uncharted behavioral alterations which might be comparable with the medical signs reported in GAMT-D sufferers, together with mental incapacity, poor speech, and autistic-like behaviors, in addition to unexplored Cr-induced cerebral alterations.
Techniques genetics evaluation of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance
We now have been utilizing the Inbred Lengthy- and Quick-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to research the genetic underpinnings of acute ethanol tolerance which is taken into account to be a threat issue for alcohol use issues (AUDs).
Right here, we’ve got used RNA-seq to look at the transcriptome of complete mind in 40 of the LXS strains eight hours after a saline or ethanol “pretreatment” as in earlier behavioral research. Roughly 1/Three of the 14,184 expressed genes had been considerably heritable and lots of had been distinctive to the pretreatment.
A number of thousand cis- and trans-eQTLs had been mapped; a portion of those additionally had been distinctive to pretreatment. Ethanol pretreatment triggered differential expression (DE) of 1,230 genes. Gene Ontology (GO) enrichment evaluation advised involvement in quite a few organic processes together with astrocyte differentiation, histone acetylation, mRNA splicing, and neuron projection growth.
Genetic correlation evaluation recognized a whole bunch of genes that had been correlated to the behaviors. GO evaluation indicated that these genes are concerned in gene expression, chromosome group, and protein transport, amongst others.
The expression profiles of the DE genes and genes correlated to AFT within the ethanol pretreatment group (AFT-Et) had been discovered to be just like profiles of HDAC inhibitors. Hdac1, a cis-regulated gene that’s situated on the peak of a beforehand mapped QTL for AFT-Et, was correlated to 437 genes, most of which had been additionally correlated to AFT-Et.
GO evaluation of those genes recognized a number of enriched organic course of phrases together with neuron-neuron synaptic transmission and potassium transport. In abstract, the outcomes recommend widespread genetic results on gene expression, together with results which might be pretreatment-specific.
Quite a lot of candidate genes and organic capabilities had been recognized that may very well be mediating the behavioral responses. Probably the most outstanding of those was Hdac1 which can be regulating genes related to glutamatergic signaling and potassium conductance.

Electroporation and genetic provide of Cas9 improve the era effectivity of CRISPR/Cas9 knock-in alleles in C57BL/6J mouse zygotes
CRISPR/Cas9 equipment delivered as ribonucleoprotein (RNP) to the zygote has grow to be a normal software for the event of genetically modified mouse fashions. In recent times, numerous experiences have demonstrated the efficient supply of CRISPR/Cas9 equipment through zygote electroporation as an alternative choice to the standard supply methodology of microinjection.
On this examine, we’ve got carried out side-by-side comparisons of the 2 RNP supply strategies throughout a number of gene loci and conclude that electroporation compares very favourably with typical pronuclear microinjection, and report an enchancment in mutagenesis effectivity when delivering CRISPR through electroporation for the era of straightforward knock-in alleles utilizing single-stranded oligodeoxynucleotide (ssODN) restore templates.
As well as, we present that the effectivity of knock-in mutagenesis could be additional elevated by electroporation of embryos derived from Cas9-expressing donor females. The maternal provide of Cas9 to the zygote avoids the need to ship the comparatively massive Cas9 protein, and excessive effectivity era of each indel and knock-in allele could be achieved by electroporation of small single-guide RNAs and ssODN restore templates alone.
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-b-96T | DL Develop | 96T | EUR 858 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-c-48T | DL Develop | 48T | EUR 632.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-c-96T | DL Develop | 96T | EUR 825.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-Hu-48T | DL Develop | 48T | EUR 456 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-Hu-96T | DL Develop | 96T | EUR 582 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-p-48T | DL Develop | 48T | EUR 656.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-p-96T | DL Develop | 96T | EUR 858 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-Ra-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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DLR-LIF-Ra-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-b-48Tests | Reddot Biotech | 48 Tests | EUR 666 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-b-96Tests | Reddot Biotech | 96 Tests | EUR 925.2 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-c-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-c-96Tests | Reddot Biotech | 96 Tests | EUR 888 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 440.4 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 602.4 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-p-48Tests | Reddot Biotech | 48 Tests | EUR 666 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-p-96Tests | Reddot Biotech | 96 Tests | EUR 925.2 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RD-LIF-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-b-48Tests | Reddot Biotech | 48 Tests | EUR 696 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-b-96Tests | Reddot Biotech | 96 Tests | EUR 968.4 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-c-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-c-96Tests | Reddot Biotech | 96 Tests | EUR 928.8 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 459.6 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 630 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-p-48Tests | Reddot Biotech | 48 Tests | EUR 696 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-p-96Tests | Reddot Biotech | 96 Tests | EUR 968.4 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
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RDR-LIF-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
LIF, mouse |
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MO16102 | Neuromics | 100 ug | EUR 810 |
LIF, Mouse |
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HY-P7084 | MedChemExpress | 50ug | EUR 639.6 |
Anti-LIF Antibody |
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A01400 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-LIF Antibody |
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PA1562 | BosterBio | 100ug/vial | EUR 352.8 |
anti- LIF antibody |
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LSMab09804 | Lifescience Market | 100 ug | EUR 463.2 |
anti- LIF antibody |
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FNab09804 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against LIF |
Anti-LIF Antibody |
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PB9036 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-LIF antibody |
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STJ29846 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Anti-LIF antibody |
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STJ73631 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-LIF antibody |
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STJ96472 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to LIF. |
Mouse LIF shRNA Plasmid |
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20-abx971321 | Abbexa |
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Mouse LIF ELISA Kit |
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EML0014 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Mouse LIF Protein |
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R01400-1 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-LIF (aa28-39) antibody |
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STJ72919 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat anti-GST α-form |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
LIF Antibody |
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1-CSB-PA198481 | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100 |
LIF Antibody |
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1-CSB-PA004761 | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
LIF Antibody |
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DF13730 | Affbiotech | 100ul | EUR 420 |
rHu LIF |
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AK9977-0005 | Akron Biotech | 5µg | Ask for price |
rHu LIF |
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AK9977-0025 | Akron Biotech | 25µg | Ask for price |
rHu LIF |
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AK9977-0100 | Akron Biotech | 100µg | Ask for price |
rHu LIF |
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AK9977-1000 | Akron Biotech | 1mg | Ask for price |
LIF Antibody |
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1-CSB-PA012928ESR2HU | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
LIF antibody |
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70R-51295 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal LIF antibody |
LIF antibody |
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70R-6230 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Rabbit polyclonal LIF antibody |
LIF Peptide |
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43-200P | ProSci | 0.1 mg | EUR 405.6 |
LIF antibody |
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70R-12299 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal LIF antibody |
LIF Antibody |
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6245-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation. |
LIF Antibody |
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6245-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation. |
LIF Peptide |
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6245P | ProSci | 0.05 mg | EUR 197.7 |
Description: (IN) LIF peptide |
LIF antibody |
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70R-14100 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal LIF antibody |
LIF Antibody |
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36950-100ul | SAB | 100ul | EUR 302.4 |
LIF protein |
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30R-2771 | Fitzgerald | 10 ug | EUR 442.8 |
Description: Purified recombinant Human LIF protein |
LIF protein |
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30R-2772 | Fitzgerald | 10 ug | EUR 586.8 |
Description: Purified recombinant Mouse LIF protein |
LIF Antibody |
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25283-100ul | SAB | 100ul | EUR 468 |
LIF siRNA |
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20-abx922546 | Abbexa |
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LIF siRNA |
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20-abx922547 | Abbexa |
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LIF, human |
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MO16101 | Neuromics | 100 ug | EUR 825.6 |
LIF, Human |
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HY-P7049 | MedChemExpress | 10ug | EUR 1920 |
LIF antibody |
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PAab09804 | Lifescience Market | 100 ug | EUR 463.2 |
LIF Antibody |
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R30639 | NSJ Bioreagents | 100 ug | EUR 419 |
LIF Antibody |
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R31467 | NSJ Bioreagents | 100 ug | EUR 419 |
LIF Antibody |
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R36251-100UG | NSJ Bioreagents | 100 ug | EUR 399 |
LIF Antibody |
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5216-100 | Biovision | each | EUR 379.2 |
LIF Antibody |
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5216-30T | Biovision | each | EUR 175.2 |
LIF Antibody |
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F49998-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
LIF Antibody |
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F49998-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
Mouse LIF PicoKine ELISA Kit |
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EK0580 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA). |
ELISA kit for Mouse LIF |
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EK5250 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse LIF in samples from serum, plasma, tissue homogenates and other biological fluids. |
LIF ELISA Kit (Mouse) (OKBB00760) |
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OKBB00760 | Aviva Systems Biology | 96 Wells | EUR 606 |
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
LIF ELISA Kit (Mouse) (OKEH04045) |
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OKEH04045 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL |
LIF, Mouse Recombinant , 1MIU/ml |
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L4500-001 | GenDepot | 1ml | EUR 406.8 |
LIF, Mouse Recombinant , 1MIU/ml |
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L4500-005 | GenDepot | 5x1ml | EUR 1431.6 |
LIF, Mouse Recombinant , 10MIU/ml |
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L4501-001 | GenDepot | 1ml | EUR 1744.8 |
Lif ORF Vector (Mouse) (pORF) |
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ORF049145 | ABM | 1.0 ug DNA | EUR 607.2 |
Lif ORF Vector (Mouse) (pORF) |
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ORF049146 | ABM | 1.0 ug DNA | EUR 607.2 |
Leukemia Inhibitory Factor (LIF), mouse |
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PR16102 | Neuromics | 5 ug | EUR 522 |
Human CellExp? LIF, mouse recombinant |
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7268-10 | Biovision | each | EUR 444 |
LIF Polyclonal Antibody |
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ABP52838-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF |
LIF Polyclonal Antibody |
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ABP52838-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF |
LIF Polyclonal Antibody |
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ABP52838-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF |
LIF Conjugated Antibody |
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C36950 | SAB | 100ul | EUR 476.4 |
LIF Polyclonal Antibody |
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ES3837-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
LIF Polyclonal Antibody |
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ES3837-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
LIF Recombinant Protein |
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91-014 | ProSci | 0.05 mg | EUR 651.3 |
Description: Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid level. Human LIF is equally active on human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells than human LIF. |
LIF Recombinant Protein |
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91-575 | ProSci | 0.05 mg | EUR 588.3 |
Description: Mouse Leukemia inhibitory factor(lif)is a secreted protein which belongs to the LIF/OSM family.LIF has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. it has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. |
LIF Rabbit pAb |
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A1288-100ul | Abclonal | 100 ul | EUR 369.6 |
LIF Rabbit pAb |
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A1288-200ul | Abclonal | 200 ul | EUR 550.8 |
LIF Rabbit pAb |
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A1288-20ul | Abclonal | 20 ul | EUR 219.6 |
LIF Rabbit pAb |
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A1288-50ul | Abclonal | 50 ul | EUR 267.6 |
LIF Blocking Peptide |
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33R-4712 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LIF antibody, catalog no. 70R-6230 |
LIF Recombinant Protein |
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40-682 | ProSci | 5 ug | EUR 311.1 |
Description: LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Murine LIF is a 19.9 kDa protein containing 180 amino acids residues, including three disulfide bonds. |
LIF Recombinant Protein |
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40-684 | ProSci | 5 ug | EUR 311.1 |
Description: LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. |
LIF Polyclonal Antibody |
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41551-100ul | SAB | 100ul | EUR 302.4 |
LIF Polyclonal Antibody |
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41551-50ul | SAB | 50ul | EUR 224.4 |
LIF Blocking Peptide |
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20-abx064170 | Abbexa |
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LIF Recombinant Protein |
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97-011 | ProSci | 0.02 mg | EUR 468.6 |
Description: Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells. |
LIF Recombinant Protein |
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90-277 | ProSci | 10 ug | EUR 405.6 |
Description: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF. |
Polyclonal LIF Antibody |
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APR06696G | Leading Biology | 0.1 mg | EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF . This antibody is tested and proven to work in the following applications: |
Polyclonal LIF Antibody |
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APR00279G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF . This antibody is tested and proven to work in the following applications: |
LIF, human recombinant |
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4923-10 | Biovision | each | EUR 366 |
LIF, human recombinant |
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4923-1000 | Biovision | each | EUR 6846 |
LIF, human recombinant |
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4923-50 | Biovision | each | EUR 796.8 |
LIF, murine recombinant |
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4924-10 | Biovision | each | EUR 444 |
LIF, murine recombinant |
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4924-1000 | Biovision | each | EUR 8203.2 |
Recombinant Mouse Leukemia Inhibitory Factor/lIF |
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C690-10ug | Novoprotein | 10ug | EUR 175.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Mouse Leukemia Inhibitory Factor/lIF |
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C690-1mg | Novoprotein | 1mg | EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Mouse Leukemia Inhibitory Factor/lIF |
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C690-500ug | Novoprotein | 500ug | EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Mouse Leukemia Inhibitory Factor/lIF |
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C690-50ug | Novoprotein | 50ug | EUR 363.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Mouse Leukemia Inhibitory Factor (LIF) Protein |
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20-abx067761 | Abbexa |
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Mouse Leukemia Inhibitory Factor (LIF) Protein |
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abx262959-1mg | Abbexa | 1 mg | EUR 3801.6 |
Mouse Leukemia Inhibitory Factor (LIF) Protein |
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abx262959-3x10g | Abbexa | 3x10 µg | EUR 393.6 |
Mouse Leukemia Inhibitory Factor (LIF) Protein |
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abx262959-3x2g | Abbexa | 3x2 µg | EUR 276 |
Lif sgRNA CRISPR Lentivector set (Mouse) |
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K3872501 | ABM | 3 x 1.0 ug | EUR 406.8 |
Nori® Mouse LIF ELISA Kit |
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GR117058 | Genorise Scientific | 96-well | EUR 553.2 |
LIF, Leukemia inhibitory factor, murine (mouse) |
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RC234-18 | Bio Basic | 5ug | EUR 125.26 |
Mouse Leukemia inhibitory factor, LIF ELISA kit |
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CSB-E04652m-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Leukemia inhibitory factor, LIF ELISA kit |
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1-CSB-E04652m | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Leukemia inhibitory factor,LIF ELISA kit |
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CN-02441M1 | ChemNorm | 96T | EUR 560.4 |
Mouse Leukemia inhibitory factor,LIF ELISA kit |
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CN-02441M2 | ChemNorm | 48T | EUR 379.2 |
Mouse Lif/ Leukemia inhibitory factor ELISA Kit |
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E1656Mo | Sunlong | 1 Kit | EUR 655.2 |
Mouse Lif(Leukemia inhibitory factor) ELISA Kit |
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EM0237 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.9pg/ml |
Mouse Leukemia Inhibitory Factor (LIF) CLIA Kit |
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abx195395-96tests | Abbexa | 96 tests | EUR 990 |
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Moreover, electroporation, in comparison with microinjection, leads to the next price of embryo survival and growth. The tactic thus has the potential to cut back the variety of animals used within the manufacturing of genetically modified mouse fashions.
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