Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Peripheral nerve accidents end in pronounced alterations in dorsal root ganglia (DRG), which might result in the event of neuropathic ache. Though the polymodal mechanosensitive transient receptor potential ankyrin 1 ion channel (TRPA1) is rising as a related goal for potential analgesic therapies, preclinical research don’t present unequivocal mechanistic perception into its relevance for neuropathic ache pathogenesis.
By using a transgenic mouse mannequin with a conditional depletion of the interleukin-6 sign transducer gp130 in Nav1.eight expressing neurons (SNS-gp130-/-), we offer a mechanistic regulatory hyperlink between IL-6/gp130 and TRPA1 within the spared nerve damage mannequin (SNI).
SNI mice developed profound mechanical hypersensitivity as indicated by elevated responses within the von Frey behavioral check in vivo, in addition to a big improve in mechanosensitivity of unmyelinated nociceptive major afferents in ex vivo pores and skin nerve recordings.
In distinction to wild sort and management gp130fl/fl animals, SNS-gp130-/- mice didn’t develop mechanical hypersensitivity after SNI and exhibited low ranges of Trpa1 mRNA in sensory neurons, which had been partially restored by adenoviral gp130 re-expression in vitro.
Importantly, unhurt however not injured neurons developed elevated responsivenesshe TRPA1 to t agonist cinnamon aldehyde (CA), and neurons derived from SNS-gp130-/- mice after SNI had been considerably much less attentive to CA. Our research exhibits for the primary time that TRPA1 upregulation is attributed particularly to unhurt neurons within the SNI mannequin and this relied on the IL-6 sign transducer gp130.
We offer an answer to the enigma of TRPA1 regulation following nerve damage and stress its significance as an essential goal for neuropathic ache problems.

Era and Surgical Evaluation of Genetic Mouse Fashions to Research NF-κB-Pushed Pathogenesis of Diffuse Giant B Cell Lymphoma

Enforced activation of NF-κB signaling will be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or through lymphoma-associated mutants of MYD88, CARD11, and CD79B. With a view to mannequin Diffuse Giant B Cell Lymphoma (DLBCL) in mice, conditional alleles for these proteins are mixed with alleles focusing on Cre recombinase expression in mature B cells.
Nonetheless, unopposed NF-κB signaling promotes plasmablast differentiation, and as a consequence the mannequin system have to be complemented with additional mutations that block differentiation, resembling Prdm1/BLIMP1 inactivation or overexpression of BCL6. Right here, we describe the presently out there instruments for DLBCL fashions in mice and their relative benefits and disadvantages.
Moreover, we describe strategies to observe lymphomagenesis, utilizing ultrasound tomography of the spleen, and the strategy of partial splenectomy surgical procedure with restoration. These highly effective strategies enable paired comparability of particular person lymphoma circumstances earlier than and after interventions, together with therapies, and to review the evolution of lymphoma over time.
NF-κB activation additionally promotes widespread nodal involvement with lymphoma and we describe the autopsy dissection of main nodal teams.

Induction of Stress-Induced Renal Mobile Senescence In Vitro: Impression of Mouse Pressure Genetic Range

Mobile senescence, a stress-induced state of irreversible cell cycle arrest, is related to organ dysfunction and age-related illness. Whereas immortalized cell strains bypass key pathways of senescence, essential mechanisms of mobile senescence will be studied in major cells. Main tubular epithelial cells (PTEC) derived from mouse kidney are extremely prone to develop mobile senescence, offering a useful software for finding out such mechanisms.
Right here, we examined whether or not genetic variations between mouse inbred strains have an effect on the event of stress-induced mobile senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice had been used to isolate PTEC.
Cells had been monitored for expression of typical senescence markers (SA-β-galactosidase, γ-H2AX+/Ki67-, expression ranges of CDKN2A, lamin B1, IL-1a/b, IL-6, G/M-CSF, IFN-g, and KC) at three and 10 days after pro-senescent gamma irradiation. Clear variations had been discovered between PTEC from completely different strains with the best senescence values for PTEC from WSB mice and the bottom for PTEC from 129S1 mice.
PTEC from B6 mice, probably the most generally used inbred pressure in senescence analysis, had a senescence rating decrease than PTEC from WSB and CAST mice however increased than PTEC from NZO and 129S1 mice. These knowledge present new info relating to the affect of genetic variety and assist clarify heterogeneity in present knowledge.
The noticed variations must be thought-about when designing new experiments and would be the foundation for additional investigation with the aim of figuring out candidate loci driving pro- or anti-senescent pathways.

Combining Human Illness Genetics and Mouse Mannequin Phenotypes in the direction of Drug Repositioning for Parkinson’s illness.

Parkinson’s illness (PD) is a extreme neurodegenerative dysfunction with out efficient therapies. Right here, we current a novel drug repositioning method to foretell new medication for PD leveraging each illness genetics and huge quantities of mouse mannequin phenotypes.
First, we recognized PD-specific mouse phenotypes utilizing well-studied human illness genes. Then we searched all FDA-approved medication for candidates that share comparable mouse phenotype profiles with PD. We demonstrated the validity of our method utilizing medication which have been authorized for PD: 10 authorized PD medication had been ranked inside high 10% amongst 1197 candidates.
In predicting novel PD medication, our method achieved a imply common precision of 0.24, which is considerably increased (p<e-11) than 0.16 for a state-of-art drug discovery method primarily based on mouse phenotype knowledge. Comparability of gene expression profiles between PD and top-ranked drug candidates signifies that quetiapine has the potential to deal with PD.
Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Genetic backgrounds and modifier genes of NTD mouse fashions: A chance for better understanding of the multifactorial etiology of neural tube defects.

Neurulation, the early embryonic means of forming the presumptive mind and spinal twine, is extremely complicated and entails tons of of genes in a number of genetic pathways. Mice have lengthy served as a genetic mannequin for finding out human neurulation, and the ensuing neural tube defects (NTDs) that come up when neurulation is disrupted.
As a result of mice seem to indicate principally single gene inheritance for NTDs and people present multifactorial inheritance, mice typically have been characterised as a less complicated mannequin for the identification and research of NTD genes.
However are they a easy mannequin? When considered on completely different genetic backgrounds, many genes present important variation within the penetrance and expressivity of NTD phenotypes, suggesting the presence of modifier loci that work together with the goal gene to have an effect on the phenotypic expression.
Taking a look at mutations on completely different genetic backgrounds gives us with a possibility to discover these complicated genetic interactions, that are prone to higher emulate comparable processes in human neurulation. Right here, we evaluation NTD genes identified to indicate strain-specific phenotypic variation.
We focus notably on the gene Cecr2, which is studied utilizing each a hypomorphic and a presumptive null mutation on two completely different backgrounds: one prone (BALB/c) and one resistant (FVB/N) to NTDs. This pressure distinction has led to a seek for genetic modifiers inside a area on murine chromosome 19.

Mouse CXCL1/KC ELISA Kit

MBS9135758-96Tests 96Tests
EUR 570

Mouse KC (CXCL1) Recombinant Protein

M10-027 20 µg
EUR 196.35
Description: All three isoforms of GRO or KC are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Mouse KC (CXCL1) Recombinant Protein

M10-027S 5 µg
EUR 92.4
Description: All three isoforms of GRO or KC are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Recombinant Mouse KC/CXCL1 protein

CD00330-5ug 5ug
EUR 176
Description: Mouse CXCL1, also known as KC, is belonging to the CXC chemokine family. It is encoded by the GRO gene now designated CXCL1. The gene for CXCL1 was initially discovered in mouse fibroblasts by plateletderived growth factor. KC is member of the intercrine alpha (chemokine C-X-C) subfamily of chemokines. It is secreted by human melanoma cells, and also expressed by macrophages, neutrophils and epithelial cells. The functional receptor for CXCL1 has been identified as CXCR2. CXCL1 has chemotactic activity for neutrophils, and plays a role in inflammation and wound healing. Amino acid sequence of Mouse CXCL1 is approximately 60 % identical to the human CXCL1. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.

Mouse GRO/KC (CXCL1), (Recombinant)

22060572-1 5 µg
EUR 146.42

Recombinant Mouse GRO/KC (CXCL1)

7-01858 5µg Ask for price

Recombinant Mouse GRO/KC (CXCL1)

7-01859 20µg Ask for price

Recombinant Mouse GRO/KC (CXCL1)

7-01860 1mg Ask for price

Recombinant Mouse GRO/KC (CXCL1)

MBS142042-0005mg 0.005mg
EUR 240

Recombinant Mouse GRO/KC (CXCL1)

MBS142042-002mg 0.02mg
EUR 310

Recombinant Mouse GRO/KC (CXCL1)

MBS142042-1mg 1mg
EUR 2880

Recombinant Mouse GRO/KC (CXCL1)

MBS142042-5x1mg 5x1mg
EUR 12630

GRO1/KC Mouse Recombinant (CXCL1)

rAP-0159 Inquiry Ask for price

Recombinant Mouse (E.Coli) GRO/KC (CXCL1)

RP-1037 5 ug
EUR 196.8

GRO1/KC Mouse Recombinant Protein (CXCL1)

PROTP12850-1 Regular: 20ug
EUR 380.4
Description: KC Mouse Recombinant also known as N51 and GRO1 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of approximately 8 kDa.;The GRO-1 is purified by proprietary chromatographic techniques.

GRO1/KC Mouse, GRO/KC (CXCL1) Mouse Recombinant Protein, His Tag

PROTP12850 Regular: 20ug
EUR 380.4
Description: GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (25-96 a.a.) and having a molecular mass of 10.5kDa.;GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Mouse Cxcl1/KC Protein, His Tag

E40MOP2119 20ug
EUR 495

KC (CXCL1) (AP)

MBS6484085-01mL 0.1mL
EUR 1100

KC (CXCL1) (AP)

MBS6484085-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (PE)

MBS6484095-01mL 0.1mL
EUR 1100

KC (CXCL1) (PE)

MBS6484095-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (APC)

MBS6484086-01mL 0.1mL
EUR 1100

KC (CXCL1) (APC)

MBS6484086-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (HRP)

MBS6484089-01mL 0.1mL
EUR 1100

KC (CXCL1) (HRP)

MBS6484089-5x01mL 5x0.1mL
EUR 4810

GRO/KC (CXCL1) Mouse Recombinant, His Tag

rAP-0149 Inquiry Ask for price

Recombinant Mouse GRO/KC (CXCL1), His Tag

MBS144372-0005mg 0.005mg
EUR 240

Recombinant Mouse GRO/KC (CXCL1), His Tag

MBS144372-002mg 0.02mg
EUR 310

Recombinant Mouse GRO/KC (CXCL1), His Tag

MBS144372-1mg 1mg
EUR 3770

Recombinant Mouse GRO/KC (CXCL1), His Tag

MBS144372-5x1mg 5x1mg
EUR 16645

KC (CXCL1) (FITC)

MBS6484088-01mL 0.1mL
EUR 1100

KC (CXCL1) (FITC)

MBS6484088-5x01mL 5x0.1mL
EUR 4810

GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse)

RC332-12 5ug
EUR 125.26

KC (CXCL1) (Biotin)

MBS6003763-005mg 0.05(mg
EUR 810

KC (CXCL1) (Biotin)

MBS6003763-5x005mg 5x0.05mg
EUR 3490

KC (CXCL1) (Biotin)

MBS6484087-01mL 0.1mL
EUR 1100

KC (CXCL1) (Biotin)

MBS6484087-5x01mL 5x0.1mL
EUR 4810

CXCL1 (Gro, KC) (AP)

MBS6470964-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (AP)

MBS6470964-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (PE)

MBS6470974-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (PE)

MBS6470974-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (APC)

MBS6470965-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (APC)

MBS6470965-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (HRP)

MBS6470968-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (HRP)

MBS6470968-5x01mL 5x0.1mL
EUR 4875

Rat GRO/KC (CXCL1)

MBS691984-0005mg 0.005mg
EUR 300

Rat GRO/KC (CXCL1)

MBS691984-0025mg 0.025mg
EUR 450

Rat GRO/KC (CXCL1)

MBS691984-5x0025mg 5x0.025mg
EUR 1725

CXCL1 (Gro, KC) (FITC)

MBS6470967-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (FITC)

MBS6470967-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (Biotin)

MBS6470966-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (Biotin)

MBS6470966-5x01mL 5x0.1mL
EUR 4875

GRO / KC (CXCL1) Protein

20-abx261870
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  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

GRO / KC (CXCL1) Protein

20-abx260684
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  • Ask for price
  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

GRO / KC (CXCL1) Protein

abx261870-10mg 10 mg
EUR 325

GRO / KC (CXCL1) Protein

abx261870-25mg 25 mg
EUR 4625

GRO / KC (CXCL1) Protein

abx261870-5mg 5 mg
EUR 225

GRO / KC (CXCL1) Protein

abx260684-10g 10 µg
EUR 325

GRO / KC (CXCL1) Protein

abx260684-2g 2 µg
EUR 225

KC (CXCL1) (MaxLight 405)

MBS6484090-01mL 0.1mL
EUR 1100

KC (CXCL1) (MaxLight 405)

MBS6484090-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (MaxLight 490)

MBS6484091-01mL 0.1mL
EUR 1100

KC (CXCL1) (MaxLight 490)

MBS6484091-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (MaxLight 550)

MBS6484092-01mL 0.1mL
EUR 1100

KC (CXCL1) (MaxLight 550)

MBS6484092-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (MaxLight 650)

MBS6484093-01mL 0.1mL
EUR 1100

KC (CXCL1) (MaxLight 650)

MBS6484093-5x01mL 5x0.1mL
EUR 4810

KC (CXCL1) (MaxLight 750)

MBS6484094-01mL 0.1mL
EUR 1100

KC (CXCL1) (MaxLight 750)

MBS6484094-5x01mL 5x0.1mL
EUR 4810

RABBIT ANTI MOUSE CXCL1

MBS221269-01mg 0.1mg
EUR 635

RABBIT ANTI MOUSE CXCL1

MBS221269-5x01mg 5x0.1mg
EUR 2695

Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit

YLA0122MO-48T 48T Ask for price

Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit

YLA0122MO-96T 96T Ask for price

Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT

E1520Mo-1096T 10*96T
EUR 4122

Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT

E1520Mo-48wells 48 wells
EUR 300

Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT

E1520Mo-596T 5*96T
EUR 2061

Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT

E1520Mo-96wells 96 wells
EUR 458

Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit

MBS1601112-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit

MBS1601112-48StripWells 48-Strip-Wells
EUR 305

Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit

MBS1601112-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit

MBS1601112-96StripWells 96-Strip-Wells
EUR 475

Recombinant Murine KC/CXCL1

AP60329 100ug
EUR 896

Recombinant Murine KC/CXCL1

P1481-.005 5ug
EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Murine KC/CXCL1

P1481-.1 100ug
EUR 900
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Murine KC/CXCL1

P1481-.5 500ug
EUR 2021.6
Description: Peptides & Proteins|Recombinant Proteins

Mouse CXC-Chemokine ligand 1, CXCL1/KC GENLISA ELISA

KLM1520 1 x 96 wells
EUR 341

RABBIT ANTI MOUSE CXCL1:Biotin

MBS220128-005mg 0.05mg
EUR 635

RABBIT ANTI MOUSE CXCL1:Biotin

MBS220128-5x005mg 5x0.05mg
EUR 2680

Rat CXCL1/KC ELISA Kit

E28L0667 96T
EUR 666.67

GRO, KC, CXCL1, rRtGRO, rat

RC352-12 5ug
EUR 125.26

CXCL1 (Gro, KC) (MaxLight 405)

MBS6470969-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (MaxLight 405)

MBS6470969-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (MaxLight 490)

MBS6470970-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (MaxLight 490)

MBS6470970-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (MaxLight 550)

MBS6470971-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (MaxLight 550)

MBS6470971-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (MaxLight 650)

MBS6470972-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (MaxLight 650)

MBS6470972-5x01mL 5x0.1mL
EUR 4875

CXCL1 (Gro, KC) (MaxLight 750)

MBS6470973-01mL 0.1mL
EUR 1115

CXCL1 (Gro, KC) (MaxLight 750)

MBS6470973-5x01mL 5x0.1mL
EUR 4875

GRO/KC (CXCL1), Rat Recombinant

P1288-25 each
EUR 444

GRO/KC (CXCL1), Rat Recombinant

P1288-5 each
EUR 210

Recombinant Murine KC (CXCL1) Protein

PROTP12850-2 20ug
EUR 380.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Mouse CXCL1

QY-E21800 96T
EUR 420

Rabbit Anti Mouse Cxcl1 Polyclonal Antibody

CPBT-65100RM 0.1 mg
EUR 1057.2

Mouse CXCL1 Antibody

GWB-28E0B5 0.1 mg Ask for price

CXCL1, Mouse

E34M009M 5 μg
EUR 155

CXCL1, Mouse

MBS8575336-0005mg 0.005mg
EUR 245

CXCL1, Mouse

MBS8575336-5x0005mg 5x0.005mg
EUR 940

Recombinant Rat GRO/KC (CXCL1) Protein

PROTP14095-1 25ug
EUR 380.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Rat GRO/KC (CXCL1) Recombinant Protein

R20-003 25 µg
EUR 196.35
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Rat GRO/KC (CXCL1) Recombinant Protein

R20-003S 5 µg
EUR 92.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

KC/CXCL1 (gro-alpha) (Recombinant) Murine

GWB-3646DB 0.02 mg Ask for price

Mouse IL-8/CXCL1/CXCL1 ELISA Kit

E16ME0008 96T
EUR 833.33

Rat CXCL1/CINC-1/KC ELISA Kit

RK00196 96 Tests
EUR 280

Rat CXCL1/CINC-1/KC ELISA Kit

MBS9135894-5x96Tests 5x96Tests
EUR 2615

Rat CXCL1/CINC-1/KC ELISA Kit

MBS9135894-96Tests 96Tests
EUR 570

Mouse CXCL1 Antibody (Biotin)

GWB-395E8D 0.05 mg Ask for price

Murine KC (CXCL1) Pre-Coated ELISA Kit

MBS697394-1Kit 1Kit
EUR 600

Murine KC (CXCL1) Pre-Coated ELISA Kit

MBS697394-5x1Kit 5x1Kit
EUR 2705

CXCL1 Antibody, Mouse MAb

MBS8124316-01mL 0.1mL
EUR 300

CXCL1 Antibody, Mouse MAb

MBS8124316-5x01mL 5x0.1mL
EUR 1200

CXCL1 Antibody, Mouse MAb

MBS8124317-01mL 0.1mL
EUR 300

CXCL1 Antibody, Mouse MAb

MBS8124317-5x01mL 5x0.1mL
EUR 1200

Mouse Monoclonal anti-human CXCL1 (GRO alpha)

hAP-0208 100ug
EUR 250

Recombinant Mouse CXCL1

Z200345 25 µg
EUR 85
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Recombinant Mouse CXCL1

Z200347 100 µg
EUR 265
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Recombinant Mouse CXCL1

Z200349 1.0 mg
EUR 2025
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Recombinant Mouse Cxcl1

MBS7616230-005mg 0.05mg
EUR 470

Recombinant Mouse Cxcl1

MBS7616230-02mg 0.2mg
EUR 885

Recombinant Mouse Cxcl1

MBS7616230-1mg 1mg
EUR 2540

Recombinant Mouse Cxcl1

MBS7616230-5x1mg 5x1mg
EUR 9820

RECOMBINANT MOUSE CXCL1

MBS232359-002mg 0.02mg
EUR 500

RECOMBINANT MOUSE CXCL1

MBS232359-5x002mg 5x0.02mg
EUR 2070

Recombinant Mouse CXCL1

MBS4159950-0025mg 0.025mg
EUR 230

Recombinant Mouse CXCL1

MBS4159950-01mg 0.1mg
EUR 420

Recombinant Mouse CXCL1

MBS4159950-1mg 1mg
EUR 2455

Recombinant Mouse CXCL1

MBS4159950-5x1mg 5x1mg
EUR 10810

CXCL1 siRNA (Mouse)

MBS8219298-15nmol 15nmol
EUR 405

CXCL1 siRNA (Mouse)

MBS8219298-30nmol 30nmol
EUR 565

CXCL1 siRNA (Mouse)

MBS8219298-5x30nmol 5x30nmol
EUR 2450

Anti-Mouse CXCL1 Antibody

103-M353 100 µg
EUR 399
Description: All three isoforms of GRO (or CXCL1) are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

CXCL1 (33-96) (Mouse)

045-48 100 μg
EUR 389.88

Mouse Monoclonal anti-human GRO (CXCL1/2/3)

hAP-1217 100ug
EUR 250

Mouse Monoclonal anti-human GRO (CXCL1/2/3)

hAP-1217A 50ug
EUR 400

Mouse CXCL1 ELISA Kit

EK5299 96 tests
EUR 599

Mouse CXCL1 ELISA Kit

55R-1741 1 kit
EUR 667
Description: ELISA kit for detection of CXCL1 in the research laboratory

Mouse CXCL1 ELISA Kit

EF012822 96tests
EUR 566

Mouse CXCL1 ELISA Kit

GWB-ZZD141 1x96 well plate Ask for price

Mouse CXCL1 ELISA Kit

MBS824609-5x96Tests 5x96Tests
EUR 2755

Mouse CXCL1 ELISA Kit

MBS824609-96Tests 96Tests
EUR 620

Mouse CXCL1 shRNA Plasmid

20-abx970673
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  • Ask for price
  • 150 µg
  • 300 µg

[Tyr0]-CXCL1 (33-96) (Mouse)

045-46 100 μg
EUR 400.68

GRO-alpha/CXCL1, Mouse

HY-P7188 50ug
EUR 639.6

Recombinant Mouse CXCL1 Protein

MBS8248896-001mg 0.01mg
EUR 235
Understanding how genetic variants alter the phenotypic end result in NTD mouse fashions will assist to direct future research in people, notably now that extra genome broad sequencing approaches are getting used. Delivery Defects Analysis 109:140-152, 2017. © 2016 Wiley Periodicals, Inc.

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