Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain
Peripheral nerve accidents end in pronounced alterations in dorsal root ganglia (DRG), which might result in the event of neuropathic ache. Though the polymodal mechanosensitive transient receptor potential ankyrin 1 ion channel (TRPA1) is rising as a related goal for potential analgesic therapies, preclinical research don’t present unequivocal mechanistic perception into its relevance for neuropathic ache pathogenesis.
By using a transgenic mouse mannequin with a conditional depletion of the interleukin-6 sign transducer gp130 in Nav1.eight expressing neurons (SNS-gp130-/-), we offer a mechanistic regulatory hyperlink between IL-6/gp130 and TRPA1 within the spared nerve damage mannequin (SNI).
SNI mice developed profound mechanical hypersensitivity as indicated by elevated responses within the von Frey behavioral check in vivo, in addition to a big improve in mechanosensitivity of unmyelinated nociceptive major afferents in ex vivo pores and skin nerve recordings.
In distinction to wild sort and management gp130fl/fl animals, SNS-gp130-/- mice didn’t develop mechanical hypersensitivity after SNI and exhibited low ranges of Trpa1 mRNA in sensory neurons, which had been partially restored by adenoviral gp130 re-expression in vitro.
Importantly, unhurt however not injured neurons developed elevated responsivenesshe TRPA1 to t agonist cinnamon aldehyde (CA), and neurons derived from SNS-gp130-/- mice after SNI had been considerably much less attentive to CA. Our research exhibits for the primary time that TRPA1 upregulation is attributed particularly to unhurt neurons within the SNI mannequin and this relied on the IL-6 sign transducer gp130.
We offer an answer to the enigma of TRPA1 regulation following nerve damage and stress its significance as an essential goal for neuropathic ache problems.
Era and Surgical Evaluation of Genetic Mouse Fashions to Research NF-κB-Pushed Pathogenesis of Diffuse Giant B Cell Lymphoma
Enforced activation of NF-κB signaling will be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or through lymphoma-associated mutants of MYD88, CARD11, and CD79B. With a view to mannequin Diffuse Giant B Cell Lymphoma (DLBCL) in mice, conditional alleles for these proteins are mixed with alleles focusing on Cre recombinase expression in mature B cells.
Nonetheless, unopposed NF-κB signaling promotes plasmablast differentiation, and as a consequence the mannequin system have to be complemented with additional mutations that block differentiation, resembling Prdm1/BLIMP1 inactivation or overexpression of BCL6. Right here, we describe the presently out there instruments for DLBCL fashions in mice and their relative benefits and disadvantages.
Moreover, we describe strategies to observe lymphomagenesis, utilizing ultrasound tomography of the spleen, and the strategy of partial splenectomy surgical procedure with restoration. These highly effective strategies enable paired comparability of particular person lymphoma circumstances earlier than and after interventions, together with therapies, and to review the evolution of lymphoma over time.
NF-κB activation additionally promotes widespread nodal involvement with lymphoma and we describe the autopsy dissection of main nodal teams.
Induction of Stress-Induced Renal Mobile Senescence In Vitro: Impression of Mouse Pressure Genetic Range
Mobile senescence, a stress-induced state of irreversible cell cycle arrest, is related to organ dysfunction and age-related illness. Whereas immortalized cell strains bypass key pathways of senescence, essential mechanisms of mobile senescence will be studied in major cells. Main tubular epithelial cells (PTEC) derived from mouse kidney are extremely prone to develop mobile senescence, offering a useful software for finding out such mechanisms.
Right here, we examined whether or not genetic variations between mouse inbred strains have an effect on the event of stress-induced mobile senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice had been used to isolate PTEC.
Cells had been monitored for expression of typical senescence markers (SA-β-galactosidase, γ-H2AX+/Ki67-, expression ranges of CDKN2A, lamin B1, IL-1a/b, IL-6, G/M-CSF, IFN-g, and KC) at three and 10 days after pro-senescent gamma irradiation. Clear variations had been discovered between PTEC from completely different strains with the best senescence values for PTEC from WSB mice and the bottom for PTEC from 129S1 mice.
PTEC from B6 mice, probably the most generally used inbred pressure in senescence analysis, had a senescence rating decrease than PTEC from WSB and CAST mice however increased than PTEC from NZO and 129S1 mice. These knowledge present new info relating to the affect of genetic variety and assist clarify heterogeneity in present knowledge.
The noticed variations must be thought-about when designing new experiments and would be the foundation for additional investigation with the aim of figuring out candidate loci driving pro- or anti-senescent pathways.
Combining Human Illness Genetics and Mouse Mannequin Phenotypes in the direction of Drug Repositioning for Parkinson’s illness.
Parkinson’s illness (PD) is a extreme neurodegenerative dysfunction with out efficient therapies. Right here, we current a novel drug repositioning method to foretell new medication for PD leveraging each illness genetics and huge quantities of mouse mannequin phenotypes.
First, we recognized PD-specific mouse phenotypes utilizing well-studied human illness genes. Then we searched all FDA-approved medication for candidates that share comparable mouse phenotype profiles with PD. We demonstrated the validity of our method utilizing medication which have been authorized for PD: 10 authorized PD medication had been ranked inside high 10% amongst 1197 candidates.
In predicting novel PD medication, our method achieved a imply common precision of 0.24, which is considerably increased (p<e-11) than 0.16 for a state-of-art drug discovery method primarily based on mouse phenotype knowledge. Comparability of gene expression profiles between PD and top-ranked drug candidates signifies that quetiapine has the potential to deal with PD.
Genetic backgrounds and modifier genes of NTD mouse fashions: A chance for better understanding of the multifactorial etiology of neural tube defects.
Neurulation, the early embryonic means of forming the presumptive mind and spinal twine, is extremely complicated and entails tons of of genes in a number of genetic pathways. Mice have lengthy served as a genetic mannequin for finding out human neurulation, and the ensuing neural tube defects (NTDs) that come up when neurulation is disrupted.
As a result of mice seem to indicate principally single gene inheritance for NTDs and people present multifactorial inheritance, mice typically have been characterised as a less complicated mannequin for the identification and research of NTD genes.
However are they a easy mannequin? When considered on completely different genetic backgrounds, many genes present important variation within the penetrance and expressivity of NTD phenotypes, suggesting the presence of modifier loci that work together with the goal gene to have an effect on the phenotypic expression.
Taking a look at mutations on completely different genetic backgrounds gives us with a possibility to discover these complicated genetic interactions, that are prone to higher emulate comparable processes in human neurulation. Right here, we evaluation NTD genes identified to indicate strain-specific phenotypic variation.
We focus notably on the gene Cecr2, which is studied utilizing each a hypomorphic and a presumptive null mutation on two completely different backgrounds: one prone (BALB/c) and one resistant (FVB/N) to NTDs. This pressure distinction has led to a seek for genetic modifiers inside a area on murine chromosome 19.
Mouse CXCL1/KC ELISA Kit |
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| RK00038 | Abclonal | 96 Tests | EUR 322.37 |
Recombinant Mouse KC/CXCL1 protein |
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| CD00330-5ug | Jiaxing Korain Biotech Ltd (BT Labs) | 5ug | EUR 176 |
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Description: Mouse CXCL1, also known as KC, is belonging to the CXC chemokine family. It is encoded by the GRO gene now designated CXCL1. The gene for CXCL1 was initially discovered in mouse fibroblasts by plateletderived growth factor. KC is member of the intercrine alpha (chemokine C-X-C) subfamily of chemokines. It is secreted by human melanoma cells, and also expressed by macrophages, neutrophils and epithelial cells. The functional receptor for CXCL1 has been identified as CXCR2. CXCL1 has chemotactic activity for neutrophils, and plays a role in inflammation and wound healing. Amino acid sequence of Mouse CXCL1 is approximately 60 % identical to the human CXCL1. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease. |
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Mouse KC (CXCL1) Recombinant Protein |
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| M10-027 | ReliaTech | 20 µg | EUR 196.35 |
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Description: All three isoforms of GRO or KC are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Mouse KC (CXCL1) Recombinant Protein |
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| M10-027S | ReliaTech | 5 µg | EUR 92.4 |
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Description: All three isoforms of GRO or KC are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Mouse CXCL1/KC Recombinant Protein |
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| PROTP12850 | BosterBio | Regular: 20ug | EUR 265 |
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Description: Mouse CXCL1/KC Recombinant Protein expressed in E. coli with His-tag. Sequence domain: 25-96aa. Application(s): SDS-PAGE. |
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Recombinant Mouse GRO/KC (CXCL1) |
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| 7-01858 | CHI Scientific | 5µg | Ask for price |
Recombinant Mouse GRO/KC (CXCL1) |
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| 7-01859 | CHI Scientific | 20µg | Ask for price |
Recombinant Mouse GRO/KC (CXCL1) |
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| 7-01860 | CHI Scientific | 1mg | Ask for price |
Mouse GRO/KC (CXCL1), (Recombinant) |
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| 22060572-1 | Bio-WORLD | 5 µg | EUR 190.94 |
Recombinant Mouse GRO/KC (CXCL1) |
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| MBS142042-0005mg | MyBiosource | 0.005mg | EUR 240 |
Recombinant Mouse GRO/KC (CXCL1) |
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| MBS142042-002mg | MyBiosource | 0.02mg | EUR 310 |
Recombinant Mouse GRO/KC (CXCL1) |
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| MBS142042-1mg | MyBiosource | 1mg | EUR 2880 |
Recombinant Mouse GRO/KC (CXCL1) |
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| MBS142042-5x1mg | MyBiosource | 5x1mg | EUR 12630 |
GRO1/KC Mouse Recombinant (CXCL1) |
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| rAP-0159 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Mouse (E.Coli) GRO/KC (CXCL1) |
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| RP-1037 | Alpha Diagnostics | 5 ug | EUR 196.8 |
GRO1/KC Mouse Recombinant Protein (CXCL1) |
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| PROTP12850-1 | BosterBio | Regular: 20ug | EUR 380.4 |
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Description: KC Mouse Recombinant also known as N51 and GRO1 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of approximately 8 kDa.;The GRO-1 is purified by proprietary chromatographic techniques. |
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Recombinant Mouse Cxcl1/KC Protein, His Tag |
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| E40MOP2119 | EnoGene | 20ug | EUR 495 |
KC (CXCL1) (AP) |
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| MBS6484085-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (AP) |
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| MBS6484085-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (PE) |
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| MBS6484095-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (PE) |
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| MBS6484095-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (APC) |
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| MBS6484086-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (APC) |
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| MBS6484086-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (HRP) |
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| MBS6484089-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (HRP) |
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| MBS6484089-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (FITC) |
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| MBS6484088-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (FITC) |
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| MBS6484088-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
Recombinant Mouse GRO/KC (CXCL1), His Tag |
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| MBS144372-0005mg | MyBiosource | 0.005mg | EUR 240 |
Recombinant Mouse GRO/KC (CXCL1), His Tag |
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| MBS144372-002mg | MyBiosource | 0.02mg | EUR 310 |
Recombinant Mouse GRO/KC (CXCL1), His Tag |
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| MBS144372-1mg | MyBiosource | 1mg | EUR 3770 |
Recombinant Mouse GRO/KC (CXCL1), His Tag |
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| MBS144372-5x1mg | MyBiosource | 5x1mg | EUR 16645 |
GRO/KC (CXCL1) Mouse Recombinant, His Tag |
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| rAP-0149 | Angio Proteomie | Inquiry | Ask for price |
GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse) |
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| RC332-12 | Bio Basic | 5ug | EUR 125.26 |
KC (CXCL1) (Biotin) |
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| MBS6484087-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (Biotin) |
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| MBS6484087-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (Biotin) |
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| MBS6003763-005mg | MyBiosource | 0.05(mg | EUR 810 |
KC (CXCL1) (Biotin) |
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| MBS6003763-5x005mg | MyBiosource | 5x0.05mg | EUR 3490 |
RecombinantGRO-α/KC/CXCL1,Mouse(CHO-expressed) |
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| BK0216 | Bioworld Biotech | 1mg | EUR 2200 |
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Description: Active at 10 ng/ml, measured in a tube formation assay using HUVEC cells. |
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Sunlong Medical™ Mouse CXCL1/KC ELISA Kit |
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| EL0012Mo-48T | Sunlong | 48T | EUR 366 |
Sunlong Medical™ Mouse CXCL1/KC ELISA Kit |
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| EL0012Mo-96T | Sunlong | 96T | EUR 455 |
CXCL1 (Gro, KC) (AP) |
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| MBS6470964-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (AP) |
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| MBS6470964-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (PE) |
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| MBS6470974-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (PE) |
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| MBS6470974-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (APC) |
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| MBS6470965-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (APC) |
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| MBS6470965-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (HRP) |
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| MBS6470968-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (HRP) |
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| MBS6470968-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
Rat GRO/KC (CXCL1) |
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| MBS691984-0005mg | MyBiosource | 0.005mg | EUR 300 |
Rat GRO/KC (CXCL1) |
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| MBS691984-0025mg | MyBiosource | 0.025mg | EUR 450 |
Rat GRO/KC (CXCL1) |
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| MBS691984-5x0025mg | MyBiosource | 5x0.025mg | EUR 1725 |
CXCL1 (Gro, KC) (FITC) |
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| MBS6470967-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (FITC) |
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| MBS6470967-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (Biotin) |
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| MBS6470966-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (Biotin) |
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| MBS6470966-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
GRO / KC (CXCL1) Protein |
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| abx260684-10g | Abbexa | 10 µg | EUR 325 |
GRO / KC (CXCL1) Protein |
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| 20-abx260684 | Abbexa |
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GRO / KC (CXCL1) Protein |
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| abx260684-2g | Abbexa | 2 µg | EUR 225 |
GRO / KC (CXCL1) Protein |
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| abx261870-10mg | Abbexa | 10 mg | EUR 325 |
GRO / KC (CXCL1) Protein |
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| 20-abx261870 | Abbexa |
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GRO / KC (CXCL1) Protein |
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| abx261870-25mg | Abbexa | 25 mg | EUR 4625 |
GRO / KC (CXCL1) Protein |
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| abx261870-5mg | Abbexa | 5 mg | EUR 225 |
KC (CXCL1) (MaxLight 405) |
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| MBS6484090-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (MaxLight 405) |
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| MBS6484090-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (MaxLight 490) |
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| MBS6484091-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (MaxLight 490) |
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| MBS6484091-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (MaxLight 550) |
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| MBS6484092-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (MaxLight 550) |
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| MBS6484092-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (MaxLight 650) |
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| MBS6484093-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (MaxLight 650) |
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| MBS6484093-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
KC (CXCL1) (MaxLight 750) |
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| MBS6484094-01mL | MyBiosource | 0.1mL | EUR 1100 |
KC (CXCL1) (MaxLight 750) |
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| MBS6484094-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
RABBIT ANTI MOUSE CXCL1 |
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| MBS221269-01mg | MyBiosource | 0.1mg | EUR 635 |
RABBIT ANTI MOUSE CXCL1 |
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| MBS221269-5x01mg | MyBiosource | 5x0.1mg | EUR 2695 |
Recombinant Murine GRO/KC/ CXCL1 (rMuKC/CXCL1) |
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| JOT-PR2018 | Jotbody | 5µg | EUR 205 |
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Description: Measured by its ability to chemoattract human CXCR2 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 3-15 ng/mL. |
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Recombinant Murine GRO/KC/ CXCL1 (rMuKC/CXCL1) |
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| PR2018 | Bioworld Biotech | 5µg | EUR 158 |
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Description: Measured by its ability to chemoattract human CXCR2 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 3-15 ng/mL. |
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Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT |
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| E1520Mo-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT |
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| E1520Mo-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT |
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| E1520Mo-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT |
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| E1520Mo-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Mouse CXC-chemokine ligand 1,CXCL1;KC ELISA KIT |
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| JOT-EK1520Mo | Jotbody | 96 wells | Ask for price |
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Description: Mouse |
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Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit |
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| MBS1601112-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3955 |
Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit |
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| MBS1601112-48StripWells | MyBiosource | 48-Strip-Wells | EUR 305 |
Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit |
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| MBS1601112-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2005 |
Mouse CXC-chemokine ligand 1 (CXCL1/KC) ELISA Kit |
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| MBS1601112-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-48T | Shanghai YL Biotech | 48T | Ask for price |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-96T | Shanghai YL Biotech | 96T | Ask for price |
Recombinant Murine KC/CXCL1 |
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| AP60329 | SAB | 100ug | EUR 896 |
Recombinant Murine KC/CXCL1 |
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| P1481-.005 | ApexBio | 5ug | EUR 108.8 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Murine KC/CXCL1 |
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| P1481-.1 | ApexBio | 100ug | EUR 900 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Murine KC/CXCL1 |
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| P1481-.5 | ApexBio | 500ug | EUR 2021.6 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Mouse CXC-Chemokine ligand 1, CXCL1/KC GENLISA ELISA |
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| KLM1520 | Krishgen | 1 x 96 wells | EUR 341 |
RABBIT ANTI MOUSE CXCL1:Biotin |
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| MBS220128-005mg | MyBiosource | 0.05mg | EUR 635 |
RABBIT ANTI MOUSE CXCL1:Biotin |
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| MBS220128-5x005mg | MyBiosource | 5x0.05mg | EUR 2680 |
Rat CXCL1/KC ELISA Kit |
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| E28L0667 | EnoGene | 96T | EUR 666.67 |
GRO, KC, CXCL1, rRtGRO, rat |
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| RC352-12 | Bio Basic | 5ug | EUR 125.26 |
CXCL1 (Gro, KC) (MaxLight 405) |
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| MBS6470969-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (MaxLight 405) |
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| MBS6470969-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (MaxLight 490) |
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| MBS6470970-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (MaxLight 490) |
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| MBS6470970-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (MaxLight 550) |
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| MBS6470971-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (MaxLight 550) |
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| MBS6470971-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (MaxLight 650) |
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| MBS6470972-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (MaxLight 650) |
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| MBS6470972-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
CXCL1 (Gro, KC) (MaxLight 750) |
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| MBS6470973-01mL | MyBiosource | 0.1mL | EUR 1115 |
CXCL1 (Gro, KC) (MaxLight 750) |
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| MBS6470973-5x01mL | MyBiosource | 5x0.1mL | EUR 4875 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-25 | Biovision | each | EUR 444 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-5 | Biovision | each | EUR 210 |
Recombinant Murine KC (CXCL1) Protein |
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| PROTP12850-2 | BosterBio | 20ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Mouse CXCL1 |
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| QY-E21800 | Qayee Biotechnology | 96T | EUR 420 |
Mouse CXCL1 Antibody |
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| GWB-28E0B5 | GenWay Biotech | 0.1 mg | Ask for price |
Rabbit Anti Mouse Cxcl1 Polyclonal Antibody |
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| CPBT-65100RM | Creative Diagnostics | 0.1 mg | EUR 659.4 |
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Description: Rabbit |
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CXCL1， Mouse |
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| E34M009M | EnoGene | 5 μg | EUR 155 |
CXCL1, Mouse |
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| MBS8575336-0005mg | MyBiosource | 0.005mg | EUR 245 |
CXCL1, Mouse |
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| MBS8575336-5x0005mg | MyBiosource | 5x0.005mg | EUR 940 |
Recombinant Rat GRO/KC (CXCL1) Protein |
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| PROTP14095-1 | BosterBio | 25ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Rat GRO/KC (CXCL1) Recombinant Protein |
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| R20-003 | ReliaTech | 25 µg | EUR 196.35 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Rat GRO/KC (CXCL1) Recombinant Protein |
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| R20-003S | ReliaTech | 5 µg | EUR 92.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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KC/CXCL1 (gro-alpha) (Recombinant) Murine |
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| GWB-3646DB | GenWay Biotech | 0.02 mg | Ask for price |
Mouse IL-8/CXCL1/CXCL1 ELISA Kit |
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| E16ME0008 | EnoGene | 96T | EUR 833.33 |
Rat CXCL1/CINC-1/KC ELISA Kit |
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| MBS9135894-5x96Tests | MyBiosource | 5x96Tests | EUR 2615 |
Rat CXCL1/CINC-1/KC ELISA Kit |
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| MBS9135894-96Tests | MyBiosource | 96Tests | EUR 570 |
Rat CXCL1/CINC-1/KC ELISA Kit |
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| RK00196 | Abclonal | 96 Tests | EUR 322.37 |
Mouse CXCL1 siRNA |
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| 20-abx913249 | Abbexa |
|
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Mouse CXCL1 Antibody (Biotin) |
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| GWB-395E8D | GenWay Biotech | 0.05 mg | Ask for price |
CXCL1 Antibody, Mouse MAb |
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| MBS8124316-01mL | MyBiosource | 0.1mL | EUR 300 |
CXCL1 Antibody, Mouse MAb |
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| MBS8124316-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
CXCL1 Antibody, Mouse MAb |
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| MBS8124317-01mL | MyBiosource | 0.1mL | EUR 300 |
CXCL1 Antibody, Mouse MAb |
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| MBS8124317-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
Murine KC (CXCL1) Pre-Coated ELISA Kit |
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| MBS697394-1Kit | MyBiosource | 1Kit | EUR 600 |
Murine KC (CXCL1) Pre-Coated ELISA Kit |
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| MBS697394-5x1Kit | MyBiosource | 5x1Kit | EUR 2705 |
Recombinant Mouse CXCL1 |
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| MBS4159950-0025mg | MyBiosource | 0.025mg | EUR 230 |
Recombinant Mouse CXCL1 |
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| MBS4159950-01mg | MyBiosource | 0.1mg | EUR 420 |
Recombinant Mouse CXCL1 |
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| MBS4159950-1mg | MyBiosource | 1mg | EUR 2455 |
Recombinant Mouse CXCL1 |
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| MBS4159950-5x1mg | MyBiosource | 5x1mg | EUR 10810 |
RECOMBINANT MOUSE CXCL1 |
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| MBS232359-002mg | MyBiosource | 0.02mg | EUR 500 |
RECOMBINANT MOUSE CXCL1 |
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| MBS232359-5x002mg | MyBiosource | 5x0.02mg | EUR 2070 |
Recombinant Mouse Cxcl1 |
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| MBS7616230-005mg | MyBiosource | 0.05mg | EUR 470 |
Recombinant Mouse Cxcl1 |
|||
| MBS7616230-02mg | MyBiosource | 0.2mg | EUR 885 |
Recombinant Mouse Cxcl1 |
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| MBS7616230-1mg | MyBiosource | 1mg | EUR 2540 |
Recombinant Mouse Cxcl1 |
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| MBS7616230-5x1mg | MyBiosource | 5x1mg | EUR 9820 |
Recombinant Mouse CXCL1 |
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| Z200345 | ABM | 25 µg | EUR 85 |
|
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. |
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Recombinant Mouse CXCL1 |
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| Z200347 | ABM | 100 µg | EUR 265 |
|
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. |
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Recombinant Mouse CXCL1 |
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| Z200349 | ABM | 1.0 mg | EUR 2025 |
|
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. |
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RecombinantGRO-α/KC/CINC-1/CXCL1,Rat |
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| BK0306 | Bioworld Biotech | 1mg | EUR 2200 |
|
Description: Active, measured in a functional assay using HUVEC cells. |
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CXCL1 siRNA (Mouse) |
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| MBS8219298-15nmol | MyBiosource | 15nmol | EUR 405 |
CXCL1 siRNA (Mouse) |
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| MBS8219298-30nmol | MyBiosource | 30nmol | EUR 565 |
CXCL1 siRNA (Mouse) |
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| MBS8219298-5x30nmol | MyBiosource | 5x30nmol | EUR 2450 |
Mouse Monoclonal anti-human CXCL1 (GRO alpha) |
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| hAP-0208 | Angio Proteomie | 100ug | EUR 250 |
CXCL1 (33-96) (Mouse) |
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| 045-48 | PHOENIX PEPTIDE | 100 μg | EUR 389.88 |
Anti-Mouse CXCL1 Antibody |
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| 103-M353 | ReliaTech | 100 µg | EUR 399 |
|
Description: All three isoforms of GRO (or CXCL1) are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Mouse Monoclonal anti-human GRO (CXCL1/2/3) |
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| hAP-1217 | Angio Proteomie | 100ug | EUR 250 |
Mouse Monoclonal anti-human GRO (CXCL1/2/3) |
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| hAP-1217A | Angio Proteomie | 50ug | EUR 400 |
Mouse CXCL1 ELISA Kit |
|||
| 55R-1741 | Fitzgerald | 1 kit | EUR 667 |
|
Description: ELISA kit for detection of CXCL1 in the research laboratory |
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Mouse CXCL1 ELISA Kit |
|||
| CEK1442 | Bioworld Biotech | 96T | EUR 538 |
|
Description: Sandwich ELKSA for quantitative detection of Mouse CXCL1 concentrations. |
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Understanding how genetic variants alter the phenotypic end result in NTD mouse fashions will assist to direct future research in people, notably now that extra genome broad sequencing approaches are getting used. Delivery Defects Analysis 109:140-152, 2017. © 2016 Wiley Periodicals, Inc.
