
Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain
Danielle
- 0
Peripheral nerve accidents end in pronounced alterations in dorsal root ganglia (DRG), which might result in the event of neuropathic ache. Though the polymodal mechanosensitive transient receptor potential ankyrin 1 ion channel (TRPA1) is rising as a related goal for potential analgesic therapies, preclinical research don’t present unequivocal mechanistic perception into its relevance for neuropathic ache pathogenesis.
By using a transgenic mouse mannequin with a conditional depletion of the interleukin-6 sign transducer gp130 in Nav1.eight expressing neurons (SNS-gp130-/-), we offer a mechanistic regulatory hyperlink between IL-6/gp130 and TRPA1 within the spared nerve damage mannequin (SNI).
SNI mice developed profound mechanical hypersensitivity as indicated by elevated responses within the von Frey behavioral check in vivo, in addition to a big improve in mechanosensitivity of unmyelinated nociceptive major afferents in ex vivo pores and skin nerve recordings.
In distinction to wild sort and management gp130fl/fl animals, SNS-gp130-/- mice didn’t develop mechanical hypersensitivity after SNI and exhibited low ranges of Trpa1 mRNA in sensory neurons, which had been partially restored by adenoviral gp130 re-expression in vitro.
Importantly, unhurt however not injured neurons developed elevated responsivenesshe TRPA1 to t agonist cinnamon aldehyde (CA), and neurons derived from SNS-gp130-/- mice after SNI had been considerably much less attentive to CA. Our research exhibits for the primary time that TRPA1 upregulation is attributed particularly to unhurt neurons within the SNI mannequin and this relied on the IL-6 sign transducer gp130.
We offer an answer to the enigma of TRPA1 regulation following nerve damage and stress its significance as an essential goal for neuropathic ache problems.
Era and Surgical Evaluation of Genetic Mouse Fashions to Research NF-κB-Pushed Pathogenesis of Diffuse Giant B Cell Lymphoma
Enforced activation of NF-κB signaling will be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or through lymphoma-associated mutants of MYD88, CARD11, and CD79B. With a view to mannequin Diffuse Giant B Cell Lymphoma (DLBCL) in mice, conditional alleles for these proteins are mixed with alleles focusing on Cre recombinase expression in mature B cells.
Nonetheless, unopposed NF-κB signaling promotes plasmablast differentiation, and as a consequence the mannequin system have to be complemented with additional mutations that block differentiation, resembling Prdm1/BLIMP1 inactivation or overexpression of BCL6. Right here, we describe the presently out there instruments for DLBCL fashions in mice and their relative benefits and disadvantages.
Moreover, we describe strategies to observe lymphomagenesis, utilizing ultrasound tomography of the spleen, and the strategy of partial splenectomy surgical procedure with restoration. These highly effective strategies enable paired comparability of particular person lymphoma circumstances earlier than and after interventions, together with therapies, and to review the evolution of lymphoma over time.
NF-κB activation additionally promotes widespread nodal involvement with lymphoma and we describe the autopsy dissection of main nodal teams.
Induction of Stress-Induced Renal Mobile Senescence In Vitro: Impression of Mouse Pressure Genetic Range
Mobile senescence, a stress-induced state of irreversible cell cycle arrest, is related to organ dysfunction and age-related illness. Whereas immortalized cell strains bypass key pathways of senescence, essential mechanisms of mobile senescence will be studied in major cells. Main tubular epithelial cells (PTEC) derived from mouse kidney are extremely prone to develop mobile senescence, offering a useful software for finding out such mechanisms.
Right here, we examined whether or not genetic variations between mouse inbred strains have an effect on the event of stress-induced mobile senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice had been used to isolate PTEC.
Cells had been monitored for expression of typical senescence markers (SA-β-galactosidase, γ-H2AX+/Ki67-, expression ranges of CDKN2A, lamin B1, IL-1a/b, IL-6, G/M-CSF, IFN-g, and KC) at three and 10 days after pro-senescent gamma irradiation. Clear variations had been discovered between PTEC from completely different strains with the best senescence values for PTEC from WSB mice and the bottom for PTEC from 129S1 mice.
PTEC from B6 mice, probably the most generally used inbred pressure in senescence analysis, had a senescence rating decrease than PTEC from WSB and CAST mice however increased than PTEC from NZO and 129S1 mice. These knowledge present new info relating to the affect of genetic variety and assist clarify heterogeneity in present knowledge.
The noticed variations must be thought-about when designing new experiments and would be the foundation for additional investigation with the aim of figuring out candidate loci driving pro- or anti-senescent pathways.
Combining Human Illness Genetics and Mouse Mannequin Phenotypes in the direction of Drug Repositioning for Parkinson’s illness.
Parkinson’s illness (PD) is a extreme neurodegenerative dysfunction with out efficient therapies. Right here, we current a novel drug repositioning method to foretell new medication for PD leveraging each illness genetics and huge quantities of mouse mannequin phenotypes.
First, we recognized PD-specific mouse phenotypes utilizing well-studied human illness genes. Then we searched all FDA-approved medication for candidates that share comparable mouse phenotype profiles with PD. We demonstrated the validity of our method utilizing medication which have been authorized for PD: 10 authorized PD medication had been ranked inside high 10% amongst 1197 candidates.
In predicting novel PD medication, our method achieved a imply common precision of 0.24, which is considerably increased (p<e-11) than 0.16 for a state-of-art drug discovery method primarily based on mouse phenotype knowledge. Comparability of gene expression profiles between PD and top-ranked drug candidates signifies that quetiapine has the potential to deal with PD.

Genetic backgrounds and modifier genes of NTD mouse fashions: A chance for better understanding of the multifactorial etiology of neural tube defects.
Neurulation, the early embryonic means of forming the presumptive mind and spinal twine, is extremely complicated and entails tons of of genes in a number of genetic pathways. Mice have lengthy served as a genetic mannequin for finding out human neurulation, and the ensuing neural tube defects (NTDs) that come up when neurulation is disrupted.
As a result of mice seem to indicate principally single gene inheritance for NTDs and people present multifactorial inheritance, mice typically have been characterised as a less complicated mannequin for the identification and research of NTD genes.
However are they a easy mannequin? When considered on completely different genetic backgrounds, many genes present important variation within the penetrance and expressivity of NTD phenotypes, suggesting the presence of modifier loci that work together with the goal gene to have an effect on the phenotypic expression.
Taking a look at mutations on completely different genetic backgrounds gives us with a possibility to discover these complicated genetic interactions, that are prone to higher emulate comparable processes in human neurulation. Right here, we evaluation NTD genes identified to indicate strain-specific phenotypic variation.
We focus notably on the gene Cecr2, which is studied utilizing each a hypomorphic and a presumptive null mutation on two completely different backgrounds: one prone (BALB/c) and one resistant (FVB/N) to NTDs. This pressure distinction has led to a seek for genetic modifiers inside a area on murine chromosome 19.
Recombinant Murine KC (CXCL1) Protein |
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PROTP12850-2 | BosterBio | 20ug | EUR 380.4 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
GRO, KC, CXCL1, rRtGRO, rat |
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RC352-12 | Bio Basic | 5ug | EUR 125.26 |
GRO/KC (CXCL1), Rat Recombinant |
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P1288-25 | Biovision | each | EUR 444 |
GRO/KC (CXCL1), Rat Recombinant |
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P1288-5 | Biovision | each | EUR 210 |
GRO1/KC Mouse, GRO/KC (CXCL1) Mouse Recombinant Protein, His Tag |
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PROTP12850 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (25-96 a.a.) and having a molecular mass of 10.5kDa.;GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse) |
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RC332-12 | Bio Basic | 5ug | EUR 125.26 |
Recombinant Rat GRO/KC (CXCL1) Protein |
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PROTP14095-1 | BosterBio | 25ug | EUR 380.4 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
Rat CXCL1/CINC-1/KC ELISA Kit |
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RK00196 | Abclonal | 96 Tests | EUR 625.2 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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YLA0122MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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YLA0122MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
KC protein (Mouse) |
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30R-AK001 | Fitzgerald | 20 ug | EUR 327.6 |
Description: Purified recombinant Mouse KC protein |
Anti-CXCL1 antibody |
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STJ28366 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. |
Anti-CXCL1 antibody |
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STJ72026 | St John's Laboratory | 100 µg | EUR 312 |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
KC antibody |
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70R-12297 | Fitzgerald | 100 ug | EUR 632.4 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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70R-12298 | Fitzgerald | 100 ug | EUR 590.4 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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20R-1786 | Fitzgerald | 100 ug | EUR 781.2 |
Description: Rabbit polyclonal KC antibody |
KC antibody |
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70R-KR006 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Affinity purified Rabbit polyclonal KC antibody |
KC Antibody |
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5211-100 | Biovision | each | EUR 451.2 |
KC Antibody |
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5212-100 | Biovision | each | EUR 470.4 |
KC Antibody |
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5212-30T | Biovision | each | EUR 175.2 |
Rabbit Anti Mouse Cxcl1 Polyclonal Antibody |
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CPBT-65100RM | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
anti-7-ketocholesterol (7-KC) (35A) |
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LF-MA90006 | Abfrontier | 20 ug | EUR 1230 |
Description: Mouse monoclonal to 7-ketocholesterol (7-KC) |
anti-7-ketocholesterol (7-KC) (35A) |
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LF-MA90007 | Abfrontier | 100 ug | EUR 3270 |
Description: Mouse monoclonal to 7-ketocholesterol (7-KC) |
KC Blocking Peptide |
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33R-11041 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298 |
KC Recombinant Protein |
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40-339-0005mg | ProSci | 0.005 mg | EUR 311.1 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
KC Recombinant Protein |
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40-339-002mg | ProSci | 0.02 mg | EUR 437.1 |
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
KC 12291 hydrochloride |
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B7332-10 | ApexBio | 10 mg | EUR 447.6 |
KC 12291 hydrochloride |
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B7332-50 | ApexBio | 50 mg | EUR 1635.6 |
Polyclonal KC Antibody |
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APR16969G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KC . This antibody is tested and proven to work in the following applications: |
KC Blocking Peptide |
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5212BP-50 | Biovision | each | EUR 183.6 |
Mouse CXCL1 ELISA Kit |
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55R-1741 | Fitzgerald | 1 kit | EUR 748.8 |
Description: ELISA kit for detection of CXCL1 in the research laboratory |
Mouse CXCL1 shRNA Plasmid |
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20-abx970673 | Abbexa |
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GRO-alpha/CXCL1, Mouse |
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HY-P7188 | MedChemExpress | 50ug | EUR 639.6 |
Anti-GRO alpha/Cxcl1 Antibody |
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A00533 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-GRO alpha/CXCL1 Antibody |
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PA1760 | BosterBio | 100ug/vial | EUR 352.8 |
KiloGreen 2X qPCR MasterMix-iCycler |
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MasterMix-KC | ABM | 4 x 1.25 ml - 500 reactions (20 ul) | EUR 168 |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse keinocyte chemoattractant (KC) ELISA kit |
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E03K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Mouse keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
CXCL1 antibody |
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70R-10502 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Affinity purified rabbit polyclonal CXCL1 antibody |
CXCL1 Antibody |
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43679-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 antibody |
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70R-16681 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal CXCL1 antibody |
CXCL1 antibody |
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70R-14297 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Affinity purified Rabbit polyclonal CXCL1 antibody |
CXCL1 antibody |
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70R-15473 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody |
CXCL1 protein |
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30R-3156 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein |
CXCL1 Peptide |
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42-129P | ProSci | 0.1 mg | EUR 405.6 |
Description: (CT) CXCL1 Peptide |
CXCL1 Antibody |
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33054-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 siRNA |
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20-abx901350 | Abbexa |
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CXCL1 siRNA |
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20-abx913248 | Abbexa |
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CXCL1 siRNA |
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20-abx913249 | Abbexa |
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Cxcl1 Antibody |
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1-CSB-PA09217A0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL1 Antibody |
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1-CSB-PA06097A0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL1 Antibody |
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1-CSB-PA006239GA01HU | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
CXCL1 Antibody |
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1-CSB-PA009036 | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
CXCL1/GRO |
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EF012822 | Lifescience Market | 96 Tests | EUR 826.8 |
CXCL1/GRO |
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E21-597 | EnoGene | 10ug | EUR 411.6 |
pEGFP- CXCL1 |
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PVT10178 | Lifescience Market | 2 ug | EUR 361.2 |
Polyclonal Goat anti-GST α-form |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
KC Kimtech precision wipes |
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CLE7552 | Scientific Laboratory Supplies | PK30 | EUR 209.76 |
KC Delicate Task Wipes |
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CLE7558 | Scientific Laboratory Supplies | PK15 | EUR 126.54 |
GRO/KC, murine recombinant |
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4210-100 | Biovision | each | EUR 927.6 |
GRO/KC, murine recombinant |
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4210-1000 | Biovision | each | EUR 4627.2 |
GRO/KC, murine recombinant |
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4210-20 | Biovision | each | EUR 307.2 |
Rabbit Anti Rat Cxcl1 Polyclonal Antibody |
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CPBT-65101RR | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Mouse CXCL1 Detection Assay Kit |
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6725 | Chondrex | 1 kit | EUR 580.26 |
Description: Mouse CXCL1 Detection Assay Kit |
CXCL1 protein (Mouse) (His tag) |
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80R-3368 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
CXCL1 protein (Mouse) (His tag) |
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80R-3439 | Fitzgerald | 50 ug | EUR 308.4 |
Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
CXCL1 ELISA Kit (Mouse) (OKBB00312) |
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OKBB00312 | Aviva Systems Biology | 96 Tests | EUR 652.8 |
Description: Description of target: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml |
Mouse CXCL1 PicoKine ELISA Kit |
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EK0723 | BosterBio | 96 wells | EUR 547.2 |
Description: For quantitative detection of mouse CXCL1 in cell culture supernates and serum. |
CXCL1 ELISA Kit (Mouse) (OKAN04583) |
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OKAN04583 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.0 pg/mL |
CXCL1 ELISA Kit (Mouse) (OKCD05712) |
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OKCD05712 | Aviva Systems Biology | 96 Wells | EUR 730.8 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.0pg/mL |
Cxcl1 ORF Vector (Mouse) (pORF) |
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ORF042286 | ABM | 1.0 ug DNA | EUR 114 |
ELISA kit for Mouse CXCL1 |
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EK5299 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CXCL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Mouse CXCL1/GROα ELISA kit |
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LF-EK50473 | Abfrontier | 1×96T | EUR 777.6 |
KC ELISA Kit (Mouse) : 96 Wells (OKAG00090) |
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OKAG00090 | Aviva Systems Biology | 96 Wells | EUR 715.2 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL |
CXCL1 antibody (HRP) |
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60R-2236 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (HRP) |
CXCL1 antibody (FITC) |
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60R-2237 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (FITC) |
CXCL1 antibody (biotin) |
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60R-2238 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal CXCL1 antibody (biotin) |
CXCL1 Blocking Peptide |
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33R-7741 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CXCL1 antibody, catalog no. 70R-10502 |
CXCL1 Recombinant Protein |
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91-532 | ProSci | 0.05 mg | EUR 714.3 |
Description: Chemokine (C-X-C motif) Ligand 1 Protein (CXCL1) is a growth factor for melanoma cells and a chemotaxin for neutrophils and a member of the CXC chemokine family that is a potent neutrophil attractant and activator and is also active toward basophils. CXCL1 is expressed by macrophages, neutrophils and epithelial cells; it has neutrophil chemoattractant activity. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection and may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. |
CXCL1 Recombinant Protein |
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91-628 | ProSci | 0.05 mg | EUR 651.3 |
Description: Cxcl1, also called Gro, Gro1, Mgsa or Scyb1, is short for growth-regulated alpha protein. The protein belongs to the intercrine alpha (chemokine CxC) family. The N-terminal processed form KC(5-72) of the protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Cxcl1 has chemotactic activity for neutrophils, and contributes to neutrophil activation during inflammation. Hematoregulatory chemokine, in vitro, suppresses hematopoietic progenitor cell proliferation. |
CXCL1 Blocking Peptide |
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20-abx061039 | Abbexa |
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CXCL1 Conjugated Antibody |
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C33054 | SAB | 100ul | EUR 476.4 |
CXCL1 cloning plasmid |
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CSB-CL006239HU-10ug | Cusabio | 10ug | EUR 279.6 |
Description: A cloning plasmid for the CXCL1 gene. |
Recombinant Human CXCL1 |
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P0109 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for CXCL1 |
Recombinant Human CXCL1 |
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P0207 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for CXCL1 |
pCMV-SPORT6-CXCL1 |
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PVT13291 | Lifescience Market | 2 ug | EUR 469.2 |
Cxcl1 Polyclonal Antibody |
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A51950-020 | EpiGentek | 20 ul | EUR 117.7 |
Cxcl1 Polyclonal Antibody |
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A51950-050 | EpiGentek | 50 ul | EUR 302.5 |
Cxcl1 Polyclonal Antibody |
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A51950-100 | EpiGentek | 100 ul | EUR 423.5 |
CXCL1 Polyclonal Antibody |
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A51978-020 | EpiGentek | 20 ul | EUR 117.7 |
CXCL1 Polyclonal Antibody |
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A51978-050 | EpiGentek | 50 ul | EUR 302.5 |
CXCL1 Polyclonal Antibody |
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A51978-100 | EpiGentek | 100 ul | EUR 423.5 |
Cxcl1 Polyclonal Antibody |
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A51950 | EpiGentek |
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CXCL1 Polyclonal Antibody |
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A51978 | EpiGentek |
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KC Hand towel 2 ply |
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KC6769 | Scientific Laboratory Supplies | PK15 | EUR 98.04 |
KC WYPALL X80 CLOTHS BLUE |
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CLE7026 | Scientific Laboratory Supplies | PK250 | EUR 188.1 |
Mouse CXCL1 AssayLite Antibody (FITC Conjugate) |
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70027-05141 | AssayPro | 150 ug | EUR 513.6 |
Mouse Growth-regulated alpha protein (Cxcl1) |
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1-CSB-RP092174m | Cusabio |
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Description: Recombinant Mouse Growth-regulated alpha protein(Cxcl1),partial expressed in E.coli |
Mouse CXCL1/GROα ELISA kit (4X96T) |
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LF-EK50474 | Abfrontier | 4×96T | EUR 2641.2 |
GRO-alpha/CXCL1 (CHO-expressed), Mouse |
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HY-P7186 | MedChemExpress | 50ug | EUR 404.4 |
Cxcl1 sgRNA CRISPR Lentivector set (Mouse) |
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K4368201 | ABM | 3 x 1.0 ug | EUR 406.8 |
Human CXCL1 ELISA Kit |
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55R-1740 | Fitzgerald | 1 kit | EUR 748.8 |
Description: ELISA kit for detection of CXCL1 in the research laboratory |
Rat CXCL1 ELISA Kit |
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55R-1742 | Fitzgerald | 1 kit | EUR 748.8 |
Description: ELISA kit for detection of CXCL1 in the research laboratory |
GRO alpha (CXCL1) Antibody |
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abx018005-100ug | Abbexa | 100 ug | EUR 410.4 |
GRO alpha (CXCL1) Protein |
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20-abx260406 | Abbexa |
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GRO alpha (CXCL1) Protein |
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20-abx261582 | Abbexa |
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GRO alpha (CXCL1) Protein |
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20-abx261606 | Abbexa |
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CXCL1 protein (His tag) |
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80R-2265 | Fitzgerald | 100 ug | EUR 508.8 |
Description: Purified recombinant Mouse CXCL1 Protein (His tag) |
Cxcl1 Antibody, HRP conjugated |
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1-CSB-PA09217B0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA |
Cxcl1 Antibody, FITC conjugated |
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1-CSB-PA09217C0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA |
Cxcl1 Antibody, Biotin conjugated |
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1-CSB-PA09217D0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL1 Antibody, HRP conjugated |
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1-CSB-PA06097B0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL1 Antibody, FITC conjugated |
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1-CSB-PA06097C0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL1 Antibody, Biotin conjugated |
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1-CSB-PA06097D0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Human CXCL1 shRNA Plasmid |
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20-abx951972 | Abbexa |
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Rat CXCL1 shRNA Plasmid |
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20-abx986581 | Abbexa |
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CXCL1 ELISA KIT|Human |
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EF003720 | Lifescience Market | 96 Tests | EUR 826.8 |
Human CXCL1 ELISA Kit |
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LF-EK50891 | Abfrontier | 1×96T | EUR 777.6 |
GRO-alpha/CXCL1, Human |
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HY-P7187 | MedChemExpress | 10ug | EUR 321.6 |
GRO-alpha/CXCL1, Rat |
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HY-P7189 | MedChemExpress | 50ug | EUR 639.6 |
Human CXCL1 ELISA Kit |
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ELA-E1210h | Lifescience Market | 96 Tests | EUR 988.8 |
pEGFP- N1- CXCL1 Plasmid |
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PVT7155 | Lifescience Market | 2 ug | EUR 319.2 |
Gro alpha Antibody / CXCL1 |
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RQ4031 | NSJ Bioreagents | 100 ug | EUR 419 |
Human GRO-alpha (CXCL1) |
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90149-A | BPS Bioscience | 5 µg | EUR 130 |
Description: Recombinant GRO-a is a disulfide-linked homodimeric protein consisting of 74 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human GRO-alpha mature chain was expressed in E. coli. |
Human GRO-alpha (CXCL1) |
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90149-B | BPS Bioscience | 25 µg | EUR 205 |
Description: Recombinant GRO-a is a disulfide-linked homodimeric protein consisting of 74 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human GRO-alpha mature chain was expressed in E. coli. |
Goat keinocyte chemoattractant (KC) ELISA kit |
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E06K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Goat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat keinocyte chemoattractant (KC) ELISA kit |
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E06K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Goat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat keinocyte chemoattractant (KC) ELISA kit |
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E06K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Goat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit keinocyte chemoattractant (KC) ELISA kit |
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E04K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rabbit keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit keinocyte chemoattractant (KC) ELISA kit |
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E04K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rabbit keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit keinocyte chemoattractant (KC) ELISA kit |
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E04K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rabbit keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human keinocyte chemoattractant (KC) ELISA kit |
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E01K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Human keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human keinocyte chemoattractant (KC) ELISA kit |
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E01K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Human keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human keinocyte chemoattractant (KC) ELISA kit |
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E01K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Human keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey keinocyte chemoattractant (KC) ELISA kit |
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E09K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Monkey keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey keinocyte chemoattractant (KC) ELISA kit |
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E09K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Monkey keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey keinocyte chemoattractant (KC) ELISA kit |
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E09K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Monkey keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat keinocyte chemoattractant (KC) ELISA kit |
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E02K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat keinocyte chemoattractant (KC) ELISA kit |
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E02K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat keinocyte chemoattractant (KC) ELISA kit |
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E02K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rat keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog keinocyte chemoattractant (KC) ELISA kit |
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E08K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Canine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog keinocyte chemoattractant (KC) ELISA kit |
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E08K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Canine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog keinocyte chemoattractant (KC) ELISA kit |
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E08K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Canine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig keinocyte chemoattractant (KC) ELISA kit |
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E07K0088-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Porcine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig keinocyte chemoattractant (KC) ELISA kit |
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E07K0088-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Porcine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig keinocyte chemoattractant (KC) ELISA kit |
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E07K0088-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Porcine keinocyte chemoattractant (KC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Cxcl1 ELISA Kit (Mouse) : 96 Wells (OKEH02714) |
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OKEH02714 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.76 pg/mL |
CXCL1 Chemi-Luminescent ELISA Kit (Mouse) (OKCD03823) |
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OKCD03823 | Aviva Systems Biology | 96 Wells | EUR 1232.4 |
Description: Description of target: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation . Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K4368202 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K4368203 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K4368204 | ABM | 1.0 ug DNA | EUR 184.8 |
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Understanding how genetic variants alter the phenotypic end result in NTD mouse fashions will assist to direct future research in people, notably now that extra genome broad sequencing approaches are getting used. Delivery Defects Analysis 109:140-152, 2017. © 2016 Wiley Periodicals, Inc.
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