Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Peripheral nerve accidents end in pronounced alterations in dorsal root ganglia (DRG), which might result in the event of neuropathic ache. Though the polymodal mechanosensitive transient receptor potential ankyrin 1 ion channel (TRPA1) is rising as a related goal for potential analgesic therapies, preclinical research don’t present unequivocal mechanistic perception into its relevance for neuropathic ache pathogenesis.
By using a transgenic mouse mannequin with a conditional depletion of the interleukin-6 sign transducer gp130 in Nav1.eight expressing neurons (SNS-gp130-/-), we offer a mechanistic regulatory hyperlink between IL-6/gp130 and TRPA1 within the spared nerve damage mannequin (SNI).
SNI mice developed profound mechanical hypersensitivity as indicated by elevated responses within the von Frey behavioral check in vivo, in addition to a big improve in mechanosensitivity of unmyelinated nociceptive major afferents in ex vivo pores and skin nerve recordings.
In distinction to wild sort and management gp130fl/fl animals, SNS-gp130-/- mice didn’t develop mechanical hypersensitivity after SNI and exhibited low ranges of Trpa1 mRNA in sensory neurons, which had been partially restored by adenoviral gp130 re-expression in vitro.
Importantly, unhurt however not injured neurons developed elevated responsivenesshe TRPA1 to t agonist cinnamon aldehyde (CA), and neurons derived from SNS-gp130-/- mice after SNI had been considerably much less attentive to CA. Our research exhibits for the primary time that TRPA1 upregulation is attributed particularly to unhurt neurons within the SNI mannequin and this relied on the IL-6 sign transducer gp130.
We offer an answer to the enigma of TRPA1 regulation following nerve damage and stress its significance as an essential goal for neuropathic ache problems.

Era and Surgical Evaluation of Genetic Mouse Fashions to Research NF-κB-Pushed Pathogenesis of Diffuse Giant B Cell Lymphoma

Enforced activation of NF-κB signaling will be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or through lymphoma-associated mutants of MYD88, CARD11, and CD79B. With a view to mannequin Diffuse Giant B Cell Lymphoma (DLBCL) in mice, conditional alleles for these proteins are mixed with alleles focusing on Cre recombinase expression in mature B cells.
Nonetheless, unopposed NF-κB signaling promotes plasmablast differentiation, and as a consequence the mannequin system have to be complemented with additional mutations that block differentiation, resembling Prdm1/BLIMP1 inactivation or overexpression of BCL6. Right here, we describe the presently out there instruments for DLBCL fashions in mice and their relative benefits and disadvantages.
Moreover, we describe strategies to observe lymphomagenesis, utilizing ultrasound tomography of the spleen, and the strategy of partial splenectomy surgical procedure with restoration. These highly effective strategies enable paired comparability of particular person lymphoma circumstances earlier than and after interventions, together with therapies, and to review the evolution of lymphoma over time.
NF-κB activation additionally promotes widespread nodal involvement with lymphoma and we describe the autopsy dissection of main nodal teams.

Induction of Stress-Induced Renal Mobile Senescence In Vitro: Impression of Mouse Pressure Genetic Range

Mobile senescence, a stress-induced state of irreversible cell cycle arrest, is related to organ dysfunction and age-related illness. Whereas immortalized cell strains bypass key pathways of senescence, essential mechanisms of mobile senescence will be studied in major cells. Main tubular epithelial cells (PTEC) derived from mouse kidney are extremely prone to develop mobile senescence, offering a useful software for finding out such mechanisms.
Right here, we examined whether or not genetic variations between mouse inbred strains have an effect on the event of stress-induced mobile senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice had been used to isolate PTEC.
Cells had been monitored for expression of typical senescence markers (SA-β-galactosidase, γ-H2AX+/Ki67-, expression ranges of CDKN2A, lamin B1, IL-1a/b, IL-6, G/M-CSF, IFN-g, and KC) at three and 10 days after pro-senescent gamma irradiation. Clear variations had been discovered between PTEC from completely different strains with the best senescence values for PTEC from WSB mice and the bottom for PTEC from 129S1 mice.
PTEC from B6 mice, probably the most generally used inbred pressure in senescence analysis, had a senescence rating decrease than PTEC from WSB and CAST mice however increased than PTEC from NZO and 129S1 mice. These knowledge present new info relating to the affect of genetic variety and assist clarify heterogeneity in present knowledge.
The noticed variations must be thought-about when designing new experiments and would be the foundation for additional investigation with the aim of figuring out candidate loci driving pro- or anti-senescent pathways.

Combining Human Illness Genetics and Mouse Mannequin Phenotypes in the direction of Drug Repositioning for Parkinson’s illness.

Parkinson’s illness (PD) is a extreme neurodegenerative dysfunction with out efficient therapies. Right here, we current a novel drug repositioning method to foretell new medication for PD leveraging each illness genetics and huge quantities of mouse mannequin phenotypes.
First, we recognized PD-specific mouse phenotypes utilizing well-studied human illness genes. Then we searched all FDA-approved medication for candidates that share comparable mouse phenotype profiles with PD. We demonstrated the validity of our method utilizing medication which have been authorized for PD: 10 authorized PD medication had been ranked inside high 10% amongst 1197 candidates.
In predicting novel PD medication, our method achieved a imply common precision of 0.24, which is considerably increased (p<e-11) than 0.16 for a state-of-art drug discovery method primarily based on mouse phenotype knowledge. Comparability of gene expression profiles between PD and top-ranked drug candidates signifies that quetiapine has the potential to deal with PD.
Genetic and functional evidence for gp130/IL6ST-induced TRPA1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain

Genetic backgrounds and modifier genes of NTD mouse fashions: A chance for better understanding of the multifactorial etiology of neural tube defects.

Neurulation, the early embryonic means of forming the presumptive mind and spinal twine, is extremely complicated and entails tons of of genes in a number of genetic pathways. Mice have lengthy served as a genetic mannequin for finding out human neurulation, and the ensuing neural tube defects (NTDs) that come up when neurulation is disrupted.
As a result of mice seem to indicate principally single gene inheritance for NTDs and people present multifactorial inheritance, mice typically have been characterised as a less complicated mannequin for the identification and research of NTD genes.
However are they a easy mannequin? When considered on completely different genetic backgrounds, many genes present important variation within the penetrance and expressivity of NTD phenotypes, suggesting the presence of modifier loci that work together with the goal gene to have an effect on the phenotypic expression.
Taking a look at mutations on completely different genetic backgrounds gives us with a possibility to discover these complicated genetic interactions, that are prone to higher emulate comparable processes in human neurulation. Right here, we evaluation NTD genes identified to indicate strain-specific phenotypic variation.
We focus notably on the gene Cecr2, which is studied utilizing each a hypomorphic and a presumptive null mutation on two completely different backgrounds: one prone (BALB/c) and one resistant (FVB/N) to NTDs. This pressure distinction has led to a seek for genetic modifiers inside a area on murine chromosome 19.

Recombinant Mouse GRO/KC (CXCL1)

7-01859 20µg Ask for price

Recombinant Mouse GRO/KC (CXCL1)

7-01860 1mg Ask for price

Recombinant Mouse (E.Coli) GRO/KC (CXCL1)

RP-1037 5 ug
EUR 196.8

GRO1/KC Mouse Recombinant Protein (CXCL1)

PROTP12850-1 Regular: 20ug
EUR 380.4
Description: KC Mouse Recombinant also known as N51 and GRO1 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of approximately 8 kDa.;The GRO-1 is purified by proprietary chromatographic techniques.

GRO1/KC Mouse, GRO/KC (CXCL1) Mouse Recombinant Protein, His Tag

PROTP12850 Regular: 20ug
EUR 380.4
Description: GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (25-96 a.a.) and having a molecular mass of 10.5kDa.;GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Mouse Cxcl1/KC Protein, His Tag

E40MOP2119 20ug
EUR 495

GRO-alpha, KC, CXCL1 (rMuKC), murine (mouse)

RC332-12 5ug
EUR 125.26

GRO / KC (CXCL1) Protein

20-abx261870
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  • 1 mg
  • 20 ug
  • 5 ug

GRO / KC (CXCL1) Protein

20-abx260684
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  • 1 mg
  • 20 ug
  • 5 ug

Recombinant Murine KC/CXCL1

AP60329 100ug
EUR 896

Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit

YLA0122MO-48T 48T Ask for price

Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit

YLA0122MO-96T 96T Ask for price

Rat CXCL1/KC ELISA Kit

E28L0667 96T
EUR 666.67

GRO, KC, CXCL1, rRtGRO, rat

RC352-12 5ug
EUR 125.26

Mouse CXC-Chemokine ligand 1, CXCL1/KC GENLISA ELISA

KLM1520 1 x 96 wells
EUR 341

GRO/KC (CXCL1), Rat Recombinant

P1288-25 each
EUR 444

GRO/KC (CXCL1), Rat Recombinant

P1288-5 each
EUR 210

Recombinant Murine KC (CXCL1) Protein

PROTP12850-2 20ug
EUR 380.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Recombinant Rat GRO/KC (CXCL1) Protein

PROTP14095-1 25ug
EUR 380.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Rat GRO/KC (CXCL1) Recombinant Protein

R20-003 25 µg
EUR 196.35
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Rat GRO/KC (CXCL1) Recombinant Protein

R20-003S 5 µg
EUR 92.4
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

KC/CXCL1 (gro-alpha) (Recombinant) Murine

GWB-3646DB 0.02 mg Ask for price

Rat CXCL1/CINC-1/KC ELISA Kit

RK00196 96 Tests
EUR 280

Mouse CXCL1 Antibody

GWB-28E0B5 0.1 mg Ask for price

Rabbit Anti Mouse Cxcl1 Polyclonal Antibody

CPBT-65100RM 0.1 mg
EUR 1057.2

CXCL1, Mouse

E34M009M 5 μg
EUR 155

Mouse IL-8/CXCL1/CXCL1 ELISA Kit

E16ME0008 96T
EUR 833.33

Anti-Mouse CXCL1 Antibody

103-M353 100 µg
EUR 399
Description: All three isoforms of GRO (or CXCL1) are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Mouse CXCL1 Antibody (Biotin)

GWB-395E8D 0.05 mg Ask for price

Recombinant Mouse CXCL1

Z200345 25 µg
EUR 85
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Recombinant Mouse CXCL1

Z200347 100 µg
EUR 265
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Recombinant Mouse CXCL1

Z200349 1.0 mg
EUR 2025
Description: Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Rat CXCL1/CINC-1/KC(IL-8) ELISA kit

E22-RC008.48 48T
EUR 295

Rat CXCL1/CINC-1/KC(IL-8) ELISA kit

E22-RC008.96 96T
EUR 395

Mouse CXCL1 ELISA Kit

EK5299 96 tests
EUR 599

Mouse CXCL1 ELISA Kit

55R-1741 1 kit
EUR 667
Description: ELISA kit for detection of CXCL1 in the research laboratory

Mouse CXCL1 ELISA Kit

GWB-ZZD141 1x96 well plate Ask for price

Mouse CXCL1 shRNA Plasmid

20-abx970673
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  • 150 µg
  • 300 µg

GRO-alpha/CXCL1, Mouse

HY-P7188 50ug
EUR 639.6

Mouse CXCL1/GROα ELISA kit

LF-EK50473 1×96T
EUR 777.6

Anti-GROa(CXCL1) Antibody

Y123166 100 µl
EUR 320

Anti-Human CXCL1 Antibody

101-M347 100 µg
EUR 399
Description: Cotton rat growth-regulatedprotein (GRO) is a member of the ELR+ CXC subfamily of chemokines. The cotton rat GRO cDNA encodes a 100 amino acid (aa) precursor protein with a 27 aa putative signal peptide and a 73 aa mature protein. The predicted amino acid sequence of the mouse KC gene product indicates KC is a member of the CXC subfamily of chemokines. The protein sequence of mouse KC shows approximately 63% identity to that of mouse MIP-2. In addition, the protein sequence of KC is approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. KC mRNA is expressed in macrophages, endothelial cells, and fibroblasts.

Mouse CXCL1 PicoKine ELISA Kit

EK0723 96 wells
EUR 547.2
Description: For quantitative detection of mouse CXCL1 in cell culture supernates and serum.

Mouse CXCL1 Detection Assay Kit

6725 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

CXCL1 protein (Mouse) (His tag)

80R-3368 50 ug
EUR 587
Description: Purified recombinant CXCL1 protein (Mouse) (His tag)

CXCL1 protein (Mouse) (His tag)

80R-3439 50 ug
EUR 308.4
Description: Purified recombinant CXCL1 protein (Mouse) (His tag)

Cxcl1 ORF Vector (Mouse) (pORF)

ORF042286 1.0 ug DNA
EUR 114

CXCL1 ELISA Kit (Mouse) (OKCD05712)

OKCD05712 96 Wells
EUR 730.8
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.0pg/mL

CXCL1 ELISA Kit (Mouse) (OKAN04583)

OKAN04583 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.0 pg/mL

CXCL1 ELISA Kit (Mouse) (OKBB00312)

OKBB00312 96 Tests
EUR 652.8
Description: Description of target: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml

Cxcl1 (untagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), (10ug)

MC208599 10 µg Ask for price

Mouse CXCL1/GROα ELISA kit (4X96T)

LF-EK50474 4×96T
EUR 2641.2

Mouse CXCL1 AssayLite™ Antibody (FITC Conjugate)

70027-05141 150 ug
EUR 370

Anti-GRO alpha/Cxcl1 Antibody

A00533 100ug/vial
EUR 352.8

Anti-GRO alpha/CXCL1 Antibody

PA1760 100ug/vial
EUR 352.8

Cxcl1 (GFP-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), (10ug)

MG220966 10 µg Ask for price

Cxcl1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1)

MR220966 10 µg Ask for price

Recombinant Mouse CXCL1/GRO-alpha Protein

RP01615 10μg
EUR 156

Recombinant Mouse CXCL1/GRO-alpha Protein

RP01641 10μg
EUR 195

OKCD05712-96W - CXCL1 ELISA Kit (Mouse)

OKCD05712-96W 96Wells
EUR 500

OKEH02714-96W - Cxcl1 ELISA Kit (Mouse)

OKEH02714-96W 96Wells
EUR 425

CXCL1 Antibody

33054 100ul
EUR 439

CXCL1 Antibody

33054-100ul 100ul
EUR 302.4

CXCL1 Antibody

43679 100ul
EUR 319

CXCL1 Antibody

43679-100ul 100ul
EUR 302.4

CXCL1 Antibody

E043679 100μg/100μl
EUR 255
Description: Available in various conjugation types.

CXCL1 Antibody

1-CSB-PA006239GA01HU
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  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

CXCL1 Antibody

E95254 100ul
EUR 255
Description: Available in various conjugation types.

CXCL1 antibody

70R-14297 100 ug
EUR 530
Description: Affinity purified Rabbit polyclonal CXCL1 antibody

CXCL1 antibody

70R-15473 100 ug
EUR 302
Description: Rabbit polyclonal CXCL1 antibody

CXCL1 antibody

70R-16681 50 ul
EUR 289
Description: Rabbit polyclonal CXCL1 antibody

CXCL1 antibody

70R-10502 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal CXCL1 antibody

CXCL1 Antibody

1-CSB-PA009036
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  • 100ug
  • 50ug
Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

CXCL1 Antibody

1-CSB-PA06097A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA

Cxcl1 Antibody

1-CSB-PA09217A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA

CXCL1 Antibody

GWB-9063F3 0.05 mg Ask for price

CXCL1 Antibody

GWB-C518CF 0.05 mg Ask for price

Mouse Chemokine Ligand CXCL1 ELISA Kit

IMSCXCL1KT each
EUR 729
Description: Mouse Chemokine Ligand CXCL1 ELISA Kit

GRO-alpha/CXCL1 (CHO-expressed), Mouse

HY-P7186 50ug
EUR 404.4

Cxcl1 sgRNA CRISPR Lentivector set (Mouse)

K4368201 3 x 1.0 ug
EUR 406.8

CXCL1

CSB-CL006239HU 10 μg plasmid + 200μl Glycerol Ask for price

CXCL1

GWB-DBBCA6 0.02 mg Ask for price

Mouse Growth-regulated alpha protein (Cxcl1)

1-CSB-RP092174m
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Growth-regulated alpha protein(Cxcl1),partial expressed in E.coli

OOCA01943-25T - Mouse Cxcl1 Primer Pair 1

OOCA01943-25T 25Tests
EUR 229

OOCA01944-25T - Mouse Cxcl1 Primer Pair 2

OOCA01944-25T 25Tests
EUR 229

CXCL1 Protein Vector (Mouse) (pPM-C-HA)

PV169144 500 ng
EUR 723.6

CXCL1 Protein Vector (Mouse) (pPB-C-His)

PV169142 500 ng
EUR 723.6

CXCL1 Protein Vector (Mouse) (pPB-N-His)

PV169143 500 ng
EUR 723.6

CXCL1 Protein Vector (Mouse) (pPM-C-His)

PV169145 500 ng
EUR 723.6

Cxcl1 ELISA Kit (Mouse) : 96 Wells (OKEH02714)

OKEH02714 96 Wells
EUR 652.8
Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.76 pg/mL

Rabbit Anti Rat Cxcl1 Polyclonal Antibody

CPBT-65101RR 0.1 mg
EUR 1057.2

Nori® Mouse CXCL1/GRO-alpha ELISA Kit

GR117324 96-well
EUR 461

Lenti ORF clone of Cxcl1 (mGFP-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1)

MR220966L2 10 µg Ask for price

Lenti ORF clone of Cxcl1 (mGFP-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1)

MR220966L4 10 µg Ask for price

Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4368202 1.0 ug DNA
EUR 184.8

Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4368203 1.0 ug DNA
EUR 184.8

Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4368204 1.0 ug DNA
EUR 184.8

CXCL1 antibody (HRP)

60R-2236 100 ug
EUR 302
Description: Rabbit polyclonal CXCL1 antibody (HRP)

Rat CXCL1 Antibody

GWB-3EACC0 0.1 mg Ask for price

Anti-Human GRO (CXCL1/2/3) Antibody

101-M762 100 µg
EUR 399
Description: CXCL1, CXCL2, and CXCL3, also known respectively as GRO alpha, GRO beta (MIP-2 alpha ) and GRO gamma (MIP-2 beta ), are members of the CXC subfamily of chemokines. Mature CXCL1/2/3 proteins bind with high affinity to the IL-8 receptor type B and are potent neutrophil attractants and activators.

Mouse CXC-chemokine ligand 1 (CXCL1) ELISA Kit

SL0916Mo - Ask for price

CXCL1 antibody (FITC)

60R-2237 100 ug
EUR 302
Description: Rabbit polyclonal CXCL1 antibody (FITC)

GROα (CXCL1) Antibody

E550010-5G11-PU 100ug
EUR 295
Description: Available in various conjugation types.

GROa (CXCL1) Antibody

E560001-A-SE 100ug
EUR 295
Description: Available in various conjugation types.

Lenti ORF clone of Cxcl1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1)

MR220966L1 10 µg Ask for price

Lenti ORF clone of Cxcl1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1)

MR220966L3 10 µg Ask for price

Rabbit polyclonal anti-CXCL1 (KC) antibody

TA319046 100 µg Ask for price

CXCL1 antibody (biotin)

60R-2238 100 ug
EUR 302
Description: Rabbit polyclonal CXCL1 antibody (biotin)

CXCL1 Chemi-Luminescent ELISA Kit (Mouse) (OKCD03823)

OKCD03823 96 Wells
EUR 1232.4
Description: Description of target: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation . Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL

CXCL1/GRO

EF012822 96 Tests
EUR 826.8

CXCL1/GRO

E21-597 10ug
EUR 225
Description: Recombinant Human C-X-C Motif Chemokine 1 is produced by our Mammalian expression system and the target gene encoding Ala35-Asn107 is expressed with a 6His tag at the C-terminus.

CXCL1 Polyclonal Antibody

E95802 100ul
EUR 225
Description: Available in various conjugation types.

CXCL1 Conjugated Antibody

C33054 100ul
EUR 476.4

Cxcl1 Polyclonal Antibody

A51950
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  • Ask for price
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

CXCL1 Polyclonal Antibody

A51978
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  • Ask for price
  • Ask for price
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

CXCL1,Human

E34M161H 5 μg
EUR 155

CXCL1 siRNA

20-abx913248
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

CXCL1 siRNA

20-abx913249
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  • Ask for price
  • 15 nmol
  • 30 nmol

CXCL1 siRNA

20-abx901350
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  • Ask for price
  • 15 nmol
  • 30 nmol

pEGFP- CXCL1

PVT10178 2 ug
EUR 361.2

Mouse Cxcl1/ Growth-regulated alpha protein ELISA Kit

E0354Mo 1 Kit
EUR 543
Description: Gro,Gro1,Mgsa,Scyb1,C-X-C motif chemokine 1,Platelet-derived growth factor-inducible protein KC,Secretory protein N51

CXCL1 protein

30R-3156 50 ug
EUR 405
Description: Purified recombinant CXCL1 protein

CXCL1 Peptide

42-129P 0.1 mg
EUR 405.6
Description: (CT) CXCL1 Peptide

Mouse Growth regulated alpha protein, Cxcl1 ELISA KIT

ELI-04012m 96 Tests
EUR 1038

Lenti ORF particles, Cxcl1 (GFP-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), 200ul, >10^7 TU/mL

MR220966L2V 200 µl Ask for price

Lenti ORF particles, Cxcl1 (GFP-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), 200ul, >10^7 TU/mL

MR220966L4V 200 µl Ask for price

Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit

abx050043-96tests 96 tests
EUR 924

Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit

abx253956-96tests 96 tests
EUR 801.6

Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit

abx574645-96tests 96 tests
EUR 801.6

Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit

20-abx154438
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  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

GRO alpha (CXCL1) Antibody

abx018005-100ug 100 ug
EUR 410.4

Gro alpha Antibody / CXCL1

RQ4031 100 ug
EUR 356.15
Description: CXCL1 (Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-?). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. It is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated.

Mouse CXCL1 Recombinant Protein C-6 His Tag Lyophilized

IMSCXCL1RC6HISLY50UG each
EUR 762
Description: Mouse CXCL1 Recombinant Protein C-6 His Tag Lyophilized

OKCD03823-96W - CXCL1 Chemi-Luminescent ELISA Kit (Mouse)

OKCD03823-96W 96Wells
EUR 850

Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit

EKF60687-48T 48T
EUR 396.9

Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit

EKF60687-5x96T 5x96T
EUR 2693.25

Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit

EKF60687-96T 96T
EUR 567

Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit

EM0003 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Lenti ORF particles, Cxcl1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), 200ul, >10^7 TU/mL

MR220966L1V 200 µl Ask for price

Lenti ORF particles, Cxcl1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 1 (Cxcl1), 200ul, >10^7 TU/mL

MR220966L3V 200 µl Ask for price

CXCL1 Antibody, HRP conjugated

1-CSB-PA06097B0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Cxcl1 Antibody, HRP conjugated

1-CSB-PA09217B0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA

Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-1mg

QP1455-1mg 1mg
EUR 3427.2

Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-5ug

QP1455-5ug 5ug
EUR 163.2

CXCL1 Antibody, FITC conjugated

1-CSB-PA06097C0Rb
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Cxcl1 Antibody, FITC conjugated

1-CSB-PA09217C0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD05887-1ML - CXCL1 Antibody

OACD05887-1ML 1ml
EUR 549

OACD05888-1ML - CXCL1 Antibody

OACD05888-1ML 1ml
EUR 429

OACD05889-1ML - CXCL1 Antibody

OACD05889-1ML 1ml
EUR 549

OACD05890-1ML - CXCL1 Antibody

OACD05890-1ML 1ml
EUR 549

OACD05891-1ML - CXCL1 Antibody

OACD05891-1ML 1ml
EUR 429

OACD00109-1ML - CXCL1 Antibody

OACD00109-1ML 1ml
EUR 559

OACD00110-1ML - CXCL1 Antibody

OACD00110-1ML 1ml
EUR 699

Recombinant Mouse Growth-regulated alpha protein (Cxcl1), partial

CSB-RP092174m 5265 mg Ask for price

Recombinant Mouse Growth-regulated alpha protein(Cxcl1),partial

AP72062 1mg
EUR 2826
Understanding how genetic variants alter the phenotypic end result in NTD mouse fashions will assist to direct future research in people, notably now that extra genome broad sequencing approaches are getting used. Delivery Defects Analysis 109:140-152, 2017. © 2016 Wiley Periodicals, Inc.

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