Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Collagen sort IV alpha 1 and alpha 2 (COL4A1 and COL4A2) are main parts of just about all basement membranes. COL4A1 and COL4A2 mutations trigger a multisystem dysfunction that may have an effect on any organ however usually entails the cerebral vasculature, eyes, kidneys and skeletal muscular tissues. In recent times, affected person advocacy and…

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