Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Collagen sort IV alpha 1 and alpha 2 (COL4A1 and COL4A2) are main parts of just about all basement membranes. COL4A1 and COL4A2 mutations trigger a multisystem dysfunction that may have an effect on any organ however usually entails the cerebral vasculature, eyes, kidneys and skeletal muscular tissues. In recent times, affected person advocacy and household help teams have united underneath the identify of Gould syndrome.
The manifestations of Gould syndrome are extremely variable, and animal research counsel that allelic heterogeneity and genetic context contribute to the scientific variability. We beforehand characterised a mouse mannequin of Gould syndrome attributable to a Col4a1 mutation by which the severities of ocular anterior phase dysgenesis (ASD), myopathy and intracerebral hemorrhage (ICH) have been depending on genetic background.
Right here, we carried out a genetic modifier display to offer perception into the mechanisms contributing to Gould syndrome pathogenesis and recognized a single locus [modifier of Gould syndrome 1 (MoGS1)] on Chromosome 1 that suppressed ASD.
A separate display confirmed that the identical locus ameliorated myopathy. Apparently, MoGS1 had no impact on ICH, suggesting that this phenotype might be mechanistically distinct. We refined the MoGS1 locus to a 4.three Mb interval containing 18 protein-coding genes, together with Fn1, which encodes the extracellular matrix part fibronectin 1. Molecular evaluation confirmed that the MoGS1 locus elevated Fn1 expression, elevating the chance that suppression is achieved by a compensatory extracellular mechanism.
Moreover, we discovered proof of elevated integrin-linked kinase ranges and focal adhesion kinase phosphorylation in Col4a1 mutant mice that’s partially restored by the MoGS1 locus, implicating the involvement of integrin signaling. Taken collectively, our outcomes counsel that tissue-specific mechanistic heterogeneity contributes to the variable expressivity of Gould syndrome and that perturbations in integrin signaling might play a job in ocular and muscular manifestations.

Dopaminergic Dysregulation in Syndromic Autism Spectrum Issues: Insights From Genetic Mouse Fashions

Autism spectrum dysfunction (ASD) is a neurodevelopmental dysfunction outlined by altered social interplay and communication, and repetitive, restricted, rigid behaviors. Roughly 1.5-2% of the overall inhabitants meet the diagnostic standards for ASD and a number of other mind areas together with the cortex, amygdala, cerebellum and basal ganglia have been implicated in ASD pathophysiology.
The midbrain dopamine system is a vital modulator of mobile and synaptic operate in a number of ASD-implicated mind areas through anatomically and functionally distinct dopaminergic projections. The dopamine speculation of ASD postulates that dysregulation of dopaminergic projection pathways might contribute to the behavioral manifestations of ASD, together with altered reward worth of social stimuli, adjustments in sensorimotor processing, and motor stereotypies.
On this overview, we look at the help for the concept that cell-autonomous adjustments in dopaminergic operate are a core part of ASD pathophysiology. We talk about the human literature supporting the involvement of altered dopamine signaling in ASD together with genetic, mind imaging and pharmacologic research.
We then concentrate on genetic mouse fashions of syndromic neurodevelopmental problems by which single gene mutations result in elevated threat for ASD. We spotlight research which have straight examined dopamine neuron quantity, morphology, physiology, or output in these fashions.
Total, we discover appreciable help for the concept that the dopamine system could also be dysregulated in syndromic ASDs; nevertheless, there doesn’t seem like a constant signature and a few fashions present elevated dopaminergic operate, whereas others have poor dopamine signaling.
We conclude that dopamine dysregulation is frequent in syndromic types of ASD however that the particular adjustments could also be distinctive to every genetic dysfunction and should not account for the complete spectrum of ASD-related manifestations.

genetic mannequin to check O-GlcNAc biking in immortalized mouse embryonic fibroblasts.

O-GlcNAcylation is an plentiful posttranslational protein modification by which the monosaccharide O-GlcNAc is added to Ser/Thr residues by O-GlcNAc transferase and eliminated by O-GlcNAcase. Analyses of O-GlcNAc-mediated signaling and metabolic phenomena are sophisticated by components together with unsatisfactory inhibitors and loss-of-function cell strains missing an identical genetic backgrounds.
On this work, we generated immortalized WT, Oga knockout, and Ogt floxed allele (Ogt floxed) mouse embryonic fibroblast (MEF) cell strains with related genetic backgrounds. These strains will facilitate experiments and function a platform to check O-GlcNAc biking in mammals. As a take a look at paradigm, we used the immortalized MEF strains to research how adjustments in O-GlcNAcylation affected pathological phosphorylation of the tau protein.
The exercise of glycogen synthase kinase 3β (GSK3β), a kinase that phosphorylates tau, decreases when expressed in Oga knockout MEFs in contrast with WT cells. Phosphorylation at Thr231 in recombinant, tauopathy-associated tau with a proline-to-leucine mutation at place 301 (P301L) was altered when expressed in MEFs with altered O-GlcNAc biking.
In mixture, our knowledge help that O-GlcNAc biking not directly impacts tau phosphorylation at Thr231, however tau phosphorylation was extremely variable, even in genetically secure, immortalized MEF cells. The variable nature of tau phosphorylation noticed right here helps the necessity to use cells akin to these generated right here with genetically outlined lesions and related backgrounds to check advanced organic processes.
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Built-in evaluation of human genetic affiliation research and mouse transcriptome suggests LBH and SHF genes as novel prone genes for amyloid-β accumulation in Alzheimer’s illness.

Alzheimer’s illness (AD) is a standard neurological illness that causes dementia in people. Though the experiences of related pathological genes have been rising, the molecular mechanism resulting in the buildup of amyloid-β (Aβ) in human mind continues to be not nicely understood.
To establish novel genes that trigger accumulation of Aβ in AD sufferers, we carried out an integrative evaluation by combining a human genetic affiliation research and transcriptome evaluation in mouse mind. First, we examined genome-wide gene expression ranges within the hippocampus, evaluating them to amyloid Aβ degree in mice with blended genetic backgrounds.
Subsequent, primarily based on a GWAS statistics obtained by a earlier research with human AD topics, we obtained gene-based statistics from the SNP-based statistics. We mixed p values from the 2 forms of evaluation throughout orthologous gene pairs in human and mouse into one p worth for every gene to judge AD susceptibility.
In consequence, we discovered 5 genes with vital p values on this built-in evaluation among the many 373 genes analyzed. We additionally examined the gene expression degree of those 5 genes within the hippocampus of unbiased human AD circumstances and management topics.

Mouse Semaphorin-6A, SEMA6A ELISA Kit

MBS9316865-96StripWells 96-Strip-Wells
EUR 765

Mouse Semaphorin- 6A, Sema6a ELISA KIT

ELI-52928m 96tests
EUR 736

Mouse Semaphorin 6A (SEMA6A) ELISA Kit

abx545302-96tests 96 tests
EUR 687.5

Mouse Semaphorin 6A (SEMA6A) ELISA Kit

MBS9916583-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Semaphorin 6A (SEMA6A) ELISA Kit

MBS9916583-48StripWells 48-Strip-Wells
EUR 550

Mouse Semaphorin 6A (SEMA6A) ELISA Kit

MBS9916583-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Semaphorin 6A (SEMA6A) ELISA Kit

MBS9916583-96StripWells 96-Strip-Wells
EUR 765

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1)

MBS642567-02mL 0.2mL
EUR 695

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1)

MBS642567-5x02mL 5x0.2mL
EUR 2975

Recombinant Mouse Semaphorin-6A (Sema6a), partial

MBS1202320-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1610

Recombinant Mouse Semaphorin-6A (Sema6a), partial

MBS1202320-005mgMammalianCell 0.05mg(Mammalian-Cell)
EUR 1865

Recombinant Mouse Semaphorin-6A (Sema6a), partial

MBS1202320-05mgEColi 0.5mg(E-Coli)
EUR 1610

Recombinant Mouse Semaphorin-6A (Sema6a), partial

MBS1202320-05mgYeast 0.5mg(Yeast)
EUR 1865

Recombinant Mouse Semaphorin-6A (Sema6a), partial

MBS1202320-1mgEColi 1mg(E-Coli)
EUR 2645

Rat Monoclonal anti-mouse Semaphorin 6A

mAP-0316 100ug
EUR 250

Semaphorin 6a

GT15056 100 ug
EUR 631.2

Semaphorin 6a

MO15023 500 ug
EUR 568.8

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (AP)

MBS6346020-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (AP)

MBS6346020-5x02mL 5x0.2mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (PE)

MBS6346030-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (PE)

MBS6346030-5x02mL 5x0.2mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (APC)

MBS6346021-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (APC)

MBS6346021-5x02mL 5x0.2mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (FITC)

MBS6346023-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (FITC)

MBS6346023-5x02mL 5x0.2mL
EUR 4250

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (AP)

MBS6133662-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (AP)

MBS6133662-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) APC

MBS6138965-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) APC

MBS6138965-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (AP)

MBS6393585-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (AP)

MBS6393585-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) APC

MBS6393586-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) APC

MBS6393586-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (FITC)

MBS6393588-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (FITC)

MBS6393588-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (HRP)

MBS6393589-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (HRP)

MBS6393589-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (PE)

MBS6393595-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (PE)

MBS6393595-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (FITC)

MBS6149571-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (FITC)

MBS6149571-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (HRP)

MBS6154874-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (HRP)

MBS6154874-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (PE)

MBS6160177-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (PE)

MBS6160177-5x01mL 5x0.1mL
EUR 3800

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (Biotin)

MBS6346022-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (Biotin)

MBS6346022-5x02mL 5x0.2mL
EUR 4250

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (Biotin)

MBS6144268-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (Biotin)

MBS6144268-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (Biotin)

MBS6393587-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (Biotin)

MBS6393587-5x01mL 5x0.1mL
EUR 3990

Anti-Human Semaphorin 6A Antibody

101-M624 100 µg
EUR 399
Description: The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 405)

MBS6393590-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 405)

MBS6393590-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 490)

MBS6393591-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 490)

MBS6393591-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 550)

MBS6393592-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 550)

MBS6393592-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 650)

MBS6393593-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 650)

MBS6393593-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 750)

MBS6393594-01mL 0.1mL
EUR 920

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 750)

MBS6393594-5x01mL 5x0.1mL
EUR 3990

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 490)

MBS6203201-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 490)

MBS6203201-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 550)

MBS6213876-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 550)

MBS6213876-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 405)

MBS6192526-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 405)

MBS6192526-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 750)

MBS6235226-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 750)

MBS6235226-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 650)

MBS6224551-01mL 0.1(mL
EUR 875

Semaphorin 6A (Semaphorin-6A, SEMA6A, HT018, KIAA1368, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A1, SEMA6A-1, SEMAQ, VIA) (MaxLight 650)

MBS6224551-5x01mL 5x0.1mL
EUR 3800

Semaphorin 6A (Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1) (SEMA6A, KIAA1368, SEMAQ)

MBS619986-005mL 0.05mL
EUR 660

Semaphorin 6A (Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1) (SEMA6A, KIAA1368, SEMAQ)

MBS619986-5x005mL 5x0.05mL
EUR 2820

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 405)

MBS6346025-01mL 0.1mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 405)

MBS6346025-5x01mL 5x0.1mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 490)

MBS6346026-01mL 0.1mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 490)

MBS6346026-5x01mL 5x0.1mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 550)

MBS6346027-01mL 0.1mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 550)

MBS6346027-5x01mL 5x0.1mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 650)

MBS6346028-01mL 0.1mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 650)

MBS6346028-5x01mL 5x0.1mL
EUR 4250

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 750)

MBS6346029-01mL 0.1mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (MaxLight 750)

MBS6346029-5x01mL 5x0.1mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ)

MBS624517-02mL 0.2mL
EUR 695

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ)

MBS624517-5x02mL 5x0.2mL
EUR 2975

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (Azide free) (HRP)

MBS6346024-02mL 0.2mL
EUR 980

SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1) (Azide free) (HRP)

MBS6346024-5x02mL 5x0.2mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (AP)

MBS6498747-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (AP)

MBS6498747-5x02mL 5x0.2mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (PE)

MBS6498757-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (PE)

MBS6498757-5x02mL 5x0.2mL
EUR 4250

Mouse anti Human Semaphorin 4A/SEMA4A/Semaphorin B Monoclonal Antibody

MBS2543647-006mL 0.06mL
EUR 250

Mouse anti Human Semaphorin 4A/SEMA4A/Semaphorin B Monoclonal Antibody

MBS2543647-012mL 0.12mL
EUR 370

Mouse anti Human Semaphorin 4A/SEMA4A/Semaphorin B Monoclonal Antibody

MBS2543647-02mL 0.2mL
EUR 550

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (APC)

MBS6498748-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (APC)

MBS6498748-5x02mL 5x0.2mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (FITC)

MBS6498750-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (FITC)

MBS6498750-5x02mL 5x0.2mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (HRP)

MBS6498751-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (HRP)

MBS6498751-5x02mL 5x0.2mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (Biotin)

MBS6498749-02mL 0.2mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (Biotin)

MBS6498749-5x02mL 5x0.2mL
EUR 4250

Semaphorin 6A (SEMA6A) Antibody

abx031679-400ul 400 ul
EUR 627.6

Semaphorin 6A (SEMA6A) Antibody

abx031679-80l 80 µl
EUR 343.2

Semaphorin 6A (SEMA6A) Antibody

abx031680-400ul 400 ul
EUR 627.6

Semaphorin 6A (SEMA6A) Antibody

abx031680-80l 80 µl
EUR 343.2

Semaphorin 6A (SEMA6A) Antibody

20-abx211651
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  • Ask for price
  • 100 ul
  • 50 ul

Semaphorin 6A (SEMA6A) Antibody

20-abx212108
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

Semaphorin 6A (SEMA6A) Antibody

20-abx302320
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Semaphorin 6A Antibody / SEMA6A

RQ5921 100 ug
EUR 356.15
Description: SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein).

Semaphorin 6A (SEMA6A) Antibody

abx211651-100l 100 µl
EUR 350

Semaphorin 6A (SEMA6A) Antibody

abx211651-50l 50 µl
EUR 250

Semaphorin 6A (SEMA6A) Antibody

abx212108-100l 100 µl
EUR 350

Semaphorin 6A (SEMA6A) Antibody

abx212108-50l 50 µl
EUR 250

Semaphorin 6A (SEMA6A) Antibody

abx302320-100g 100 µg
EUR 362.5

Semaphorin 6A (SEMA6A) Antibody

abx302320-20g 20 µg
EUR 162.5

Semaphorin 6A (SEMA6A) Antibody

abx302320-50g 50 µg
EUR 250

Semaphorin 6A (SEMA6A) Antibody

abx031679-400l 400 µl
EUR 518.75

Semaphorin 6A (SEMA6A) Antibody

abx031680-400l 400 µl
EUR 518.75

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 405)

MBS6498752-01mL 0.1mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 405)

MBS6498752-5x01mL 5x0.1mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 490)

MBS6498753-01mL 0.1mL
EUR 980

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 490)

MBS6498753-5x01mL 5x0.1mL
EUR 4250

SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 550)

MBS6498754-01mL 0.1mL
EUR 980
Two genes, LBH and SHF, confirmed decrease expression ranges in AD circumstances than management topics. That is in step with the gene expression ranges of each the genes in mouse which have been negatively correlated with Aβ accumulation. These outcomes, obtained from the integrative method, counsel that LBH and SHF are related to the AD pathogenesis.

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