Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Collagen sort IV alpha 1 and alpha 2 (COL4A1 and COL4A2) are main parts of just about all basement membranes. COL4A1 and COL4A2 mutations trigger a multisystem dysfunction that may have an effect on any organ however usually entails the cerebral vasculature, eyes, kidneys and skeletal muscular tissues. In recent times, affected person advocacy and household help teams have united underneath the identify of Gould syndrome.
The manifestations of Gould syndrome are extremely variable, and animal research counsel that allelic heterogeneity and genetic context contribute to the scientific variability. We beforehand characterised a mouse mannequin of Gould syndrome attributable to a Col4a1 mutation by which the severities of ocular anterior phase dysgenesis (ASD), myopathy and intracerebral hemorrhage (ICH) have been depending on genetic background.
Right here, we carried out a genetic modifier display to offer perception into the mechanisms contributing to Gould syndrome pathogenesis and recognized a single locus [modifier of Gould syndrome 1 (MoGS1)] on Chromosome 1 that suppressed ASD.
A separate display confirmed that the identical locus ameliorated myopathy. Apparently, MoGS1 had no impact on ICH, suggesting that this phenotype might be mechanistically distinct. We refined the MoGS1 locus to a 4.three Mb interval containing 18 protein-coding genes, together with Fn1, which encodes the extracellular matrix part fibronectin 1. Molecular evaluation confirmed that the MoGS1 locus elevated Fn1 expression, elevating the chance that suppression is achieved by a compensatory extracellular mechanism.
Moreover, we discovered proof of elevated integrin-linked kinase ranges and focal adhesion kinase phosphorylation in Col4a1 mutant mice that’s partially restored by the MoGS1 locus, implicating the involvement of integrin signaling. Taken collectively, our outcomes counsel that tissue-specific mechanistic heterogeneity contributes to the variable expressivity of Gould syndrome and that perturbations in integrin signaling might play a job in ocular and muscular manifestations.

Dopaminergic Dysregulation in Syndromic Autism Spectrum Issues: Insights From Genetic Mouse Fashions

Autism spectrum dysfunction (ASD) is a neurodevelopmental dysfunction outlined by altered social interplay and communication, and repetitive, restricted, rigid behaviors. Roughly 1.5-2% of the overall inhabitants meet the diagnostic standards for ASD and a number of other mind areas together with the cortex, amygdala, cerebellum and basal ganglia have been implicated in ASD pathophysiology.
The midbrain dopamine system is a vital modulator of mobile and synaptic operate in a number of ASD-implicated mind areas through anatomically and functionally distinct dopaminergic projections. The dopamine speculation of ASD postulates that dysregulation of dopaminergic projection pathways might contribute to the behavioral manifestations of ASD, together with altered reward worth of social stimuli, adjustments in sensorimotor processing, and motor stereotypies.
On this overview, we look at the help for the concept that cell-autonomous adjustments in dopaminergic operate are a core part of ASD pathophysiology. We talk about the human literature supporting the involvement of altered dopamine signaling in ASD together with genetic, mind imaging and pharmacologic research.
We then concentrate on genetic mouse fashions of syndromic neurodevelopmental problems by which single gene mutations result in elevated threat for ASD. We spotlight research which have straight examined dopamine neuron quantity, morphology, physiology, or output in these fashions.
Total, we discover appreciable help for the concept that the dopamine system could also be dysregulated in syndromic ASDs; nevertheless, there doesn’t seem like a constant signature and a few fashions present elevated dopaminergic operate, whereas others have poor dopamine signaling.
We conclude that dopamine dysregulation is frequent in syndromic types of ASD however that the particular adjustments could also be distinctive to every genetic dysfunction and should not account for the complete spectrum of ASD-related manifestations.

genetic mannequin to check O-GlcNAc biking in immortalized mouse embryonic fibroblasts.

O-GlcNAcylation is an plentiful posttranslational protein modification by which the monosaccharide O-GlcNAc is added to Ser/Thr residues by O-GlcNAc transferase and eliminated by O-GlcNAcase. Analyses of O-GlcNAc-mediated signaling and metabolic phenomena are sophisticated by components together with unsatisfactory inhibitors and loss-of-function cell strains missing an identical genetic backgrounds.
On this work, we generated immortalized WT, Oga knockout, and Ogt floxed allele (Ogt floxed) mouse embryonic fibroblast (MEF) cell strains with related genetic backgrounds. These strains will facilitate experiments and function a platform to check O-GlcNAc biking in mammals. As a take a look at paradigm, we used the immortalized MEF strains to research how adjustments in O-GlcNAcylation affected pathological phosphorylation of the tau protein.
The exercise of glycogen synthase kinase 3β (GSK3β), a kinase that phosphorylates tau, decreases when expressed in Oga knockout MEFs in contrast with WT cells. Phosphorylation at Thr231 in recombinant, tauopathy-associated tau with a proline-to-leucine mutation at place 301 (P301L) was altered when expressed in MEFs with altered O-GlcNAc biking.
In mixture, our knowledge help that O-GlcNAc biking not directly impacts tau phosphorylation at Thr231, however tau phosphorylation was extremely variable, even in genetically secure, immortalized MEF cells. The variable nature of tau phosphorylation noticed right here helps the necessity to use cells akin to these generated right here with genetically outlined lesions and related backgrounds to check advanced organic processes.
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome

Built-in evaluation of human genetic affiliation research and mouse transcriptome suggests LBH and SHF genes as novel prone genes for amyloid-β accumulation in Alzheimer’s illness.

Alzheimer’s illness (AD) is a standard neurological illness that causes dementia in people. Though the experiences of related pathological genes have been rising, the molecular mechanism resulting in the buildup of amyloid-β (Aβ) in human mind continues to be not nicely understood.
To establish novel genes that trigger accumulation of Aβ in AD sufferers, we carried out an integrative evaluation by combining a human genetic affiliation research and transcriptome evaluation in mouse mind. First, we examined genome-wide gene expression ranges within the hippocampus, evaluating them to amyloid Aβ degree in mice with blended genetic backgrounds.
Subsequent, primarily based on a GWAS statistics obtained by a earlier research with human AD topics, we obtained gene-based statistics from the SNP-based statistics. We mixed p values from the 2 forms of evaluation throughout orthologous gene pairs in human and mouse into one p worth for every gene to judge AD susceptibility.
In consequence, we discovered 5 genes with vital p values on this built-in evaluation among the many 373 genes analyzed. We additionally examined the gene expression degree of those 5 genes within the hippocampus of unbiased human AD circumstances and management topics.

Semaphorin 6A (SEMA6A) Antibody

abx031679-400ul 400 ul
EUR 523
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Semaphorin 6A (SEMA6A) Antibody

abx031679-80l 80 µl
EUR 286
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Semaphorin 6A (SEMA6A) Antibody

abx031680-400ul 400 ul
EUR 523
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Semaphorin 6A (SEMA6A) Antibody

abx031680-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Semaphorin 6A (SEMA6A) Antibody

20-abx302320
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Mouse Semaphorin- 6A, Sema6a ELISA KIT

ELI-52928m 96 Tests
EUR 865

Human Semaphorin 6A (SEMA6A)ELISA Kit

201-12-1088 96 tests
EUR 440
  • This Semaphorin 6A ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Semaphorin- 6A, SEMA6A ELISA KIT

ELI-52440h 96 Tests
EUR 824

Human Semaphorin 6A(SEMA6A)ELISA Kit

GA-E1104HM-48T 48T
EUR 289

Human Semaphorin 6A(SEMA6A)ELISA Kit

GA-E1104HM-96T 96T
EUR 466

Human Semaphorin 6A(SEMA6A)ELISA Kit

QY-E00788 96T
EUR 361

Mouse anti-SAH 6a

MA00306-50 50µg
EUR 348
Description: Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-2

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-Rab 6A Antibody

A02911 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Rab 6A Antibody (RAB6A) detection.tested for WB in Human, Mouse, Rat.

anti- Cytokeratin 6A antibody

FNab02215 100µg
EUR 548.75
  • Recommended dilution: WB: 1:5000-1:10000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: keratin 6A
  • Uniprot ID: P02538
  • Gene ID: 3853
  • Research Area: Cancer, Immunology, Developmental biology
Description: Antibody raised against Cytokeratin 6A

Anti-Cytokeratin 6A antibody

PAab02215 100 ug
EUR 386

Anti-Rab 6A antibody

STJ95302 200 µl
EUR 197
Description: Rabbit polyclonal to Rab 6A.

anti-Anti-Semaphorin 5A

YF-PA25252 50 ul
EUR 334
Description: Mouse polyclonal to Anti-Semaphorin 5A

anti-Semaphorin 3B

YF-PA15485 100 ug
EUR 403
Description: Rabbit polyclonal to Semaphorin 3B

anti-Semaphorin 3D

YF-PA22776 50 ug
EUR 363
Description: Mouse polyclonal to Semaphorin 3D

anti-Semaphorin 3D

YF-PA22777 100 ug
EUR 403
Description: Rabbit polyclonal to Semaphorin 3D

anti-Semaphorin 3B

YF-PA25020 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 3B

anti-Semaphorin 7a

YF-PA25109 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 7a

anti-Semaphorin 3A

YF-PA25559 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 3A

anti- Cytokeratin 6A-specific antibody

FNab02216 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • Immunogen: keratin 6A
  • Uniprot ID: P02538
  • Gene ID: 3853
  • Research Area: Cancer, Immunology, Developmental biology
Description: Antibody raised against Cytokeratin 6A-specific

Anti-Cytokeratin 6A-specific antibody

PAab02216 100 ug
EUR 386

Anti Mouse Semaphorin 3B Polyclonal Antibody

KR100
EUR 649
Description: The Anti Mouse Semaphorin 3B Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Anti-Semaphorin 5A antibody

STJ70970 100 µg
EUR 359

Anti-Semaphorin 7a (3D3)

YF-MA16372 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 7a

Anti-Semaphorin 7a (1G1)

YF-MA16373 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 7a

Anti-Semaphorin 3A (5G9)

YF-MA17274 50 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 3A

Anti-Semaphorin 4D (3B4)

YF-MA17342 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 4D

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

CD6

6A-100T 100 test
EUR 349

Peptide 6A

H-6905.0005 5.0mg
EUR 297
Description: Sum Formula: C23H43N9O6; CAS# [73549-32-3]

Peptide 6A

H-6905.0025 25.0mg
EUR 1093
Description: Sum Formula: C23H43N9O6; CAS# [73549-32-3]

6a-Hydroxymaackiain

TB02758 5mg
EUR 847

6a-Senecioyloxychaparrin

TBZ0849 unit Ask for price

6a-Hydroxyeurycomalactone

TBZ1429 unit Ask for price

Anti-Semaphorin 3B/SEMA3B Antibody

A06559-1 100ug/vial
EUR 294

Anti-SEMA4A/Semaphorin 4A Antibody

A06779-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for SEMA4A Antibody (SEMA4A) detection.tested for WB in Human, Mouse, Rat, Monkey.

Anti-Semaphorin 3E/SEMA3E Antibody

A06937-2 100ug/vial
EUR 294

Anti-SEMA4C/Semaphorin 4C Antibody

A08069 100ul
EUR 397
Description: Rabbit Polyclonal SEMA4C/Semaphorin 4C Antibody. Validated in WB and tested in Human.

Anti-Semaphorin 3c/SEMA3C Antibody

A06444-1 100ug/vial
EUR 294

Anti-Semaphorin 3A/SEMA3A Antibody

A01761-1 100ug/vial
EUR 294

Anti-Semaphorin 3A/SEMA3A Antibody

PB9353 100ug/vial
EUR 294

Anti-Semaphorin 3E (internal) antibody

STJ71055 100 µg
EUR 359

Estriol 6a antibody

20-1630 100 ul
EUR 879
Description: Sheep polyclonal Estriol 6a antibody

Cytokeratin 6A Antibody

abx232215-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

pFlag- CMV- 6a

PVT10705 2 ug
EUR 301

Mouse Keratin 6A (KRT6A) ELISA Kit

abx514580-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Semaphorin 5A

GT41026 100 ug
EUR 474

Semaphorin 7A

GT15076 100 ug
EUR 539

Semaphorin 3C

GT15077 100 ug
EUR 526

Semaphorin 6B

GT15165 100 ug
EUR 526

Semaphorin 5A

P41026 100 ug Blocking Peptide
EUR 239

Semaphorin 7A

MO15041 500 ug
EUR 513

Semaphorin 3B

RA25088 50 ul
EUR 474

Rab 6A Polyclonal Antibody

41378-100ul 100ul
EUR 252

Rab 6A Polyclonal Antibody

41378-50ul 50ul
EUR 187

Keratin 6A (KRT6A) Antibody

20-abx005878
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
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Keratin 6A (KRT6A) Antibody

20-abx002875
  • EUR 411.00
  • EUR 592.00
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Keratin 6A (KRT6A) Antibody

20-abx214450
  • EUR 411.00
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Keratin 6A (KRT6A) Antibody

20-abx214451
  • EUR 411.00
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Keratin 6A (KRT6A) Antibody

20-abx100825
  • EUR 425.00
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  • EUR 1205.00
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  • Shipped within 5-7 working days.

Keratin 6A (KRT6A) Antibody

20-abx100826
  • EUR 342.00
  • EUR 857.00
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  • EUR 258.00
  • 100 ug
  • 1 mg
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  • Shipped within 5-7 working days.

Keratin 6A (KRT6A) Antibody

20-abx100827
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
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  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
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  • Shipped within 5-7 working days.

Keratin 6A (KRT6A) Antibody

20-abx113347
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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Keratin 6A (KRT6A) Antibody

20-abx109957
  • EUR 411.00
  • EUR 1845.00
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  • EUR 300.00
  • 100 ug
  • 1 mg
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  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

abx146382-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

20-abx159587
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

abx029191-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

abx029191-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

20-abx322514
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

20-abx322515
  • EUR 439.00
  • EUR 328.00
  • 100 ul
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  • Shipped within 5-10 working days.

Keratin 6A (KRT6A) Antibody

20-abx304308
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Cytokeratin 6A-specific Antibody

abx232216-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

PDE 6A Polyclonal Antibody

ABP-PAB-31042 50 ug Ask for price
    • Product line: Miscellaneous
    • Brand:

Rab 6A Polyclonal Antibody

ABP55965-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170

Rab 6A Polyclonal Antibody

ABP55965-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170

Rab 6A Polyclonal Antibody

ABP55965-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170

Rab 6A Polyclonal Antibody

ES6964-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Rab 6A from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Rab 6A Polyclonal Antibody

ES6964-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Rab 6A from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Recombinant Keratin 6A (KRT6A)

4-RPD234Hu01
  • EUR 440.48
  • EUR 221.00
  • EUR 1376.80
  • EUR 525.60
  • EUR 951.20
  • EUR 358.00
  • EUR 3292.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P02538
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 41.3kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Keratin 6A expressed in: E.coli

Recombinant Keratin 6A (KRT6A)

4-RPD234Ra01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q4FZU2
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.5kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Keratin 6A expressed in: E.coli

Mouse Semaphorin 7A ELISA kit

E03S0083-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 7A ELISA kit

E03S0083-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 7A ELISA kit

E03S0083-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 3 ELISA kit

E03S0084-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 3 ELISA kit

E03S0084-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 3 ELISA kit

E03S0084-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 4D ELISA kit

E03S0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 4D ELISA kit

E03S0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Semaphorin 4D ELISA kit

E03S0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Two genes, LBH and SHF, confirmed decrease expression ranges in AD circumstances than management topics. That is in step with the gene expression ranges of each the genes in mouse which have been negatively correlated with Aβ accumulation. These outcomes, obtained from the integrative method, counsel that LBH and SHF are related to the AD pathogenesis.

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