Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

The flexibility to control the survival and demise of a cell is paramount all through the lifespan of a multicellular organism. Apoptosis, a foremost physiological type of programmed cell demise, is regulated by the Bcl-2 household proteins which are both pro-apoptotic or pro-survival.
The in vivo features of distinct Bcl-2 members of the family are largely unmasked by genetically engineered murine fashions. Mcl-1 is likely one of the two Bcl-2 like pro-survival genes whose germline deletion causes embryonic lethality in mice.
Its requisite for the survival of a broad vary of cell varieties has been additional unraveled by utilizing conditional and inducible deletion murine mannequin programs in numerous tissues or cell lineages and at distinct developmental levels. Furthermore, genetic mouse most cancers fashions have additionally demonstrated that Mcl-1 is crucial for the survival of a number of tumor varieties.
The MCL-1 locus is often amplified throughout numerous most cancers varieties in people. Small molecule inhibitors with excessive affinity and specificity to human MCL-1 have been developed and explored for the therapy of sure cancers. To facilitate the pre-clinical research of MCL-1 in most cancers and different illnesses, transgenic mouse fashions over-expressing human MCL-1 in addition to humanized MCL-1 mouse fashions have been lately engineered.
This overview discusses the present advances in understanding the physiological roles of Mcl-1 based mostly on research utilizing genetic murine fashions and its essential implications in pathology and therapy of human illnesses.

Human B Lymphomas Reveal Their Secrets and techniques By way of Genetic Mouse Fashions

Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and symbolize the sixth most cancers worldwide and probably the most frequent blood most cancers. The vast majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal heart (GC) skilled mature B cells.
GCs are transient buildings that type in lymphoid organs in response to antigen publicity of naive B cells, and the place B cell receptor (BCR) affinity maturation happens to advertise B cell differentiation into reminiscence B and plasma cells producing high-affinity antibodies.
Genomic instability related to the somatic hypermutation (SHM) and class-switch recombination (CSR) processes throughout GC transit improve susceptibility to malignant transformation. Most B cell differentiation steps within the GC are on the origin of frequent B cell malignant entities, specifically Follicular Lymphoma (FL) and GCB diffuse massive B cell lymphomas (GCB-DLBCL).
Over the previous decade, massive sequencing efforts have offered an important enhance within the identification of candidate oncogenes and tumor suppressors concerned in FL and DLBCL oncogenesis. Mouse fashions have been instrumental to precisely mimic in vivo lymphoma-specific mutations and interrogate their regular perform within the GC context and their oncogenic perform resulting in lymphoma onset.
The restricted entry of biopsies throughout the initiating steps of the illness, the mobile and (epi)genetic heterogeneity of particular person tumors throughout and inside sufferers linked to perturbed dynamics of GC ecosystems make the event of genetically engineered mouse fashions essential to decipher lymphomagenesis and illness development and ultimately to check the consequences of novel focused therapies.
On this overview, we offer an summary of a few of the essential genetically engineered mouse fashions which have been developed to recapitulate lymphoma-associated (epi)genetic alterations of two frequent GC-derived lymphoma entities: FL and GCB-DLCBL and describe how these mouse fashions have improved our data of the molecular processes supporting GC B cell transformation.

Benefits of patient-derived orthotopic mouse fashions and genetic reporters for growing fluorescence-guided surgical procedure.

Fluorescence-guided surgical procedure can improve the surgeon’s potential to realize a whole oncologic resection. There are a selection of tumor-specific probes being developed with many preclinical mouse fashions to judge their efficacy.
The present overview discusses the completely different preclinical mouse fashions within the setting of probe analysis and highlights some great benefits of patient-derived orthotopic xenografts (PDOX) mouse fashions and genetic reporters to develop fluorescence-guided surgical procedure.
Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Modifying out 5 Serpina1 paralogs to create a mouse mannequin of genetic emphysema.

Continual obstructive pulmonary illness impacts 10% of the worldwide inhabitants, and the main genetic trigger is α-1 antitrypsin (AAT) deficiency. Because of the complexity of the murine locus, which incorporates as much as six Serpina1 paralogs, no genetic animal mannequin of the illness has been efficiently generated till now. Right here we create a quintuple Serpina1a-e knockout utilizing CRISPR/Cas9-mediated genome enhancing.
The phenotype recapitulates the human illness phenotype, i.e., absence of hepatic and circulating AAT interprets functionally to a decreased capability to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which might be induced in youthful mice by a lipopolysaccharide problem.
This mouse fashions not solely AAT deficiency but in addition emphysema and is a related genetic mannequin and never one based mostly on developmental impairment of alveolarization or elastase administration. We anticipate that this distinctive mannequin shall be extremely related not solely to the preclinical growth of therapeutics for AAT deficiency, but in addition to emphysema and smoking analysis.

Exome sequencing of the TCL1 mouse mannequin for CLL reveals genetic heterogeneity and dynamics throughout illness growth.

The TCL1 mouse mannequin is extensively used to review pathophysiology, clonal evolution, and drug sensitivity or resistance of persistent lymphocytic leukemia (CLL). By performing entire exome sequencing, we current the genetic panorama of major tumors from TCL1 mice and of TCL1 tumors serially transplanted into wild-type recipients to imitate clonal evolution.
We present that just like CLL sufferers, mutations in mice are ceaselessly subclonal and heterogenous amongst completely different major TCL1 mice. We additional describe that this molecular heterogeneity mirrors heterogenous illness traits corresponding to organ infiltration or CLL dependent T cell skewing. Just like human CLL, we additional noticed the prevalence of novel mutations and structural variations throughout clonal evolution and located plasticity within the growth of B cell receptor particular subclones.
Thus, our outcomes uncover that the genetic complexity, pathway dependence and clonal dynamics in mouse CLL are in related settlement to human CLL, and they’re essential to think about in future analysis utilizing the TCL1 mouse for learning CLL.

Spontaneous pulmonary hypertension in geneticmouse fashions of pure killer cell deficiency.

Pure Killer (NK) cells are cytotoxic innate lymphoid cells with a longtime function within the regulation of vascular construction in being pregnant and most cancers. Impaired NK cell perform has been recognized in sufferers with pulmonary arterial hypertension (PAH), a illness of obstructive vascular reworking within the lungs, in addition to in a number of rodent fashions of illness.
Nonetheless, the exact contribution of NK cell impairment to the initiation and development of PAH stays unknown. Right here we report the event of spontaneous pulmonary hypertension in two impartial genetic fashions of NK cell dysfunction, together with Nfil3-/- mice, that are poor in NK cells because of the absence of the NFIL3 transcription issue, and Ncr1-Gfp mice, which lack the NK activating receptor NKp46.
Mouse fashions of NK insufficiency exhibited elevated proper ventricular systolic stress and muscularization of the pulmonary arteries within the absence of elevated left ventricular finish diastolic stress, indicating that the event of pulmonary hypertension was not secondary to left coronary heart dysfunction.
In circumstances of extreme NK cell impairment or loss, a subset of mice didn’t develop pulmonary hypertension and as an alternative exhibited decreased systemic blood stress, demonstrating an extension of vascular abnormalities past the pulmonary circulation into the systemic vasculature.

Protein Wnt-3a (WNT3A) Antibody

20-abx136135
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

Protein Wnt-3a (WNT3A) Antibody

20-abx000791
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Protein Wnt-3a Antibody (HRP)

20-abx108677
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protein Wnt-3a Antibody (Biotin)

20-abx105841
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protein Wnt-3a Antibody (FITC)

20-abx107257
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protein Wnt-3a (WNT3A) Antibody

abx117009-100ug 100 ug
EUR 560.4

Protein Wnt-3a (WNT3A) Antibody

abx218011-100ug 100 ug
EUR 526.8

Protein Wnt-3a (WNT3A) Antibody

abx224220-100ug 100 ug
EUR 493.2

Human Protein Wnt-3a (WNT3A)

1-CSB-EP026136HU
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Protein Wnt-3a(WNT3A) expressed in E.coli

Mouse Protein Wnt-3a (Wnt3a)

1-CSB-EP026136MO
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Protein Wnt-3a(Wnt3a) expressed in E.coli

Human Protein Wnt-3a (WNT3A)

1-CSB-RP155494h
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Protein Wnt-3a(WNT3A),partial expressed in E.coli

Wnt-C59

A8685-5 5 mg
EUR 177.6
Description: Wnt-C59 is a selective inhibitor of Wnt signaling with IC50 value of 74 pM [1].

Wnt Family Member 3A (WNT3A) Antibody

20-abx211813
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Wnt Family Member 3A (WNT3A) Antibody

20-abx211920
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Protein Wnt-3a Polyclonal Conjugated Antibody

C42596 100ul
EUR 476.4

Wnt Antagonist, C59

2063-5
EUR 430.8

Mouse Protein Wnt-3a (WNT3A) ELISA Kit

abx255085-96tests 96 tests
EUR 895.2

Human Protein Wnt-3a (WNT3A) ELISA Kit

abx251482-96tests 96 tests
EUR 895.2

Chicken Protein Wnt-3a (WNT3A) ELISA Kit

abx519656-96tests 96 tests
EUR 1093.2

Human Protein Wnt-3a (WNT3A) ELISA Kit

abx570841-96tests 96 tests
EUR 801.6

Mouse Protein Wnt-3a (WNT3A) ELISA Kit

abx575000-96tests 96 tests
EUR 801.6

Human Protein Wnt-3a(WNT3A) ELISA kit

CSB-EL026136HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a (WNT3A) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Protein Wnt-3a(WNT3A) ELISA kit

1-CSB-EL026136HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a(WNT3A) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Protein Wnt-3a(WNT3A) ELISA kit

CSB-EL026136MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a (WNT3A) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Protein Wnt-3a(WNT3A) ELISA kit

1-CSB-EL026136MO
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a(WNT3A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human WNT3A(Protein Wnt-3a) ELISA Kit

EH2146 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Mouse Wnt3a(Protein Wnt-3a) ELISA Kit

EM0737 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

Mouse Wnt3a/ Protein Wnt-3a ELISA Kit

E1594Mo 1 Kit
EUR 685.2

Human WNT3A/ Protein Wnt-3a ELISA Kit

E2688Hu 1 Kit
EUR 685.2

ELISA kit for Mouse Protein Wnt-3a

EK4364 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Protein Wnt-3a

EK4365 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse Protein Wnt- 3a, Wnt3a ELISA KIT

ELI-06995m 96 Tests
EUR 1038

Chicken Protein Wnt- 3a, WNT3A ELISA KIT

ELI-06996c 96 Tests
EUR 1113.6

Human Protein Wnt- 3a, WNT3A ELISA KIT

ELI-06997h 96 Tests
EUR 988.8

BD Transforming growth factor beta 1human 1 ug

354039 EACH
EUR 279.3

BD Epidermal growth factor human recombinant 100 ug

354052 EACH
EUR 204.06

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

5-HT-3A Antibody

34152-100ul 100ul
EUR 302.4

5-HT-3A Antibody

34152-50ul 50ul
EUR 224.4

5- HT- 3A Antibody

ABD3502 100 ug
EUR 525.6

Growth Factor Set IV, StemBoost?

K426-5
EUR 1024.8

Human Growth Differentiation Factor 5 (GDF-5) Antibody

30011-05111 150 ug
EUR 313.2

Growth/differentiation factor 5 Polyclonal Antibody

42178-100ul 100ul
EUR 399.6

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx103263
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx103264
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx006710
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx009268
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx123595
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx109840
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx128010
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx128606
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

abx031516-400ul 400 ul
EUR 627.6

Growth Differentiation Factor 5 (GDF5) Antibody

abx031516-80l 80 µl
EUR 343.2

Growth Differentiation Factor 5 (GDF5) Antibody

abx026572-400ul 400 ul
EUR 627.6

Growth Differentiation Factor 5 (GDF5) Antibody

abx026572-80l 80 µl
EUR 343.2

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx320075
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx323550
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx327566
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody

abx432738-200ul 200 ul
EUR 343.2

Fibroblast Growth Factor 5 (FGF5) Antibody

abx233094-100ug 100 ug
EUR 610.8

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx172410
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx172684
  • EUR 861.60
  • EUR 460.80
  • 1 mg
  • 200 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx172685
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx176717
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx176718
  • EUR 1562.40
  • EUR 744.00
  • 1 mg
  • 200 ug

Mouse Growth/differentiation factor 5 (Gdf5)

1-CSB-EP009349MO
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Hu02
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Mu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Growth Differentiation Factor 5 expressed in: E.coli

Recombinant Fibroblast Growth Factor 5 (FGF5)

4-RPA357Hu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibroblast Growth Factor 5 expressed in: E.coli

Epidermal Growth Factor (EGF), human recombinant

P1008-.5 500 µg
EUR 375.6
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR.

Epidermal Growth Factor (EGF), human recombinant

P1008-5 5 mg
EUR 1646.4
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR.

Wnt3a ELISA Kit| Mouse Protein Wnt-3a ELISA Kit

EF013348 96 Tests
EUR 826.8

Recombinant Human Protein Wnt-3a Protein, His, E.coli-100ug

QP8838-ec-100ug 100ug
EUR 489.6

Recombinant Human Protein Wnt-3a Protein, His, E.coli-10ug

QP8838-ec-10ug 10ug
EUR 240

Recombinant Human Protein Wnt-3a Protein, His, E.coli-1mg

QP8838-ec-1mg 1mg
EUR 1958.4

Recombinant Human Protein Wnt-3a Protein, His, E.coli-200ug

QP8838-ec-200ug 200ug
EUR 760.8

Recombinant Human Protein Wnt-3a Protein, His, E.coli-500ug

QP8838-ec-500ug 500ug
EUR 1272

Recombinant Human Protein Wnt-3a Protein, His, E.coli-50ug

QP8838-ec-50ug 50ug
EUR 315.6

5-Hydroxytryptamine Receptor 3A (5-HT3A) Antibody

20-abx013887
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

5-HT-3A Blocking Peptide

DF3502-BP 1mg
EUR 234

5-HT-3A Conjugated Antibody

C34152 100ul
EUR 476.4

Epidermal Growth Factor Receptor Peptide (985-996)

A1021-5 5 mg
EUR 226.8
Description: EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by the binding of its specific ligands, including epidermal growth factor and transforming growth factor ?. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity.

Epidermal Growth Factor Receptor Peptide (985-996)

5-01114 4 x 1mg Ask for price

Insulin-like Growth Factor I (57-70)

5-01399 4 x 5mg Ask for price

Insulin-Like Growth Factor II (69-84)

5-01400 4 x 1mg Ask for price

Platelet-Derived Growth Factor Receptor Substrate 2

5-01775 4 x 1mg Ask for price

Prepro-Nerve Growth Factor (99-115) (mouse)

5-01801 4 x 1mg Ask for price

Sulfur 5 ug/g (5 PPM) for AA and ICP 100 grams in no.2 Diesel Fuel

SDFS-5-Y 100ML
EUR 102.6

Recombinant Human Growth and Differentiation factor 5

7-00469 10µg Ask for price

Recombinant Human Growth and Differentiation factor 5

7-00470 50µg Ask for price

Recombinant Human Growth and Differentiation factor 5

7-00471 1mg Ask for price

Human Growth Differentiation Factor 5 (GDF5) Protein

20-abx168181
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Fibroblast Growth Factor 5 (FGF5) Protein

20-abx168292
  • EUR 878.40
  • EUR 343.20
  • EUR 2766.00
  • EUR 1062.00
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Growth Differentiation Factor 5 (GDF5) Protein

20-abx066945
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Growth Differentiation Factor 5 (GDF5) Protein

20-abx066946
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody (Biotin)

20-abx105479
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody (HRP)

20-abx108317
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody (FITC)

20-abx106897
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth differentiation factor 5 (GDF5) polyclonal antibody

ABP-PAB-10697 100 ug Ask for price

Growth Differentiation Factor 5 (GDF5) Antibody (Biotin)

20-abx272251
  • EUR 526.80
  • EUR 292.80
  • EUR 1528.80
  • EUR 727.20
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody (Biotin)

20-abx272912
  • EUR 560.40
  • EUR 292.80
  • EUR 1612.80
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Differentiation Factor 5 (GDF5) Antibody (FITC)

20-abx273642
  • EUR 493.20
  • EUR 276.00
  • EUR 1395.60
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Growth Differentiation Factor 5 (GDF5) Protein

20-abx260380
  • EUR 276.00
  • EUR 2264.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Human Growth Differentiation Factor 5 (GDF5) Protein

20-abx260743
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Rat Growth Differentiation Factor 5 (GDF5) Protein

20-abx653648
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth/differentiation factor 5 Polyclonal Conjugated Antibody

C42178 100ul
EUR 476.4

Human Fibroblast growth factor 5 protein (FGF5)

1-CSB-RP095144h
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fibroblast growth factor 5 protein(FGF5) expressed in E.coli

Goat Fibroblast growth factor 5 ELISA kit

E06F0380-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Fibroblast growth factor 5 ELISA kit

E06F0380-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Fibroblast growth factor 5 ELISA kit

E06F0380-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Growth Differentiation Factor 5 ELISA kit

E06G0136-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Growth Differentiation Factor 5 ELISA kit

E06G0136-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Growth Differentiation Factor 5 ELISA kit

E06G0136-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Fibroblast growth factor 5 ELISA kit

E04F0380-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Fibroblast growth factor 5 ELISA kit

E04F0380-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Fibroblast growth factor 5 ELISA kit

E04F0380-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Growth Differentiation Factor 5 ELISA kit

E04G0136-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Growth Differentiation Factor 5 ELISA kit

E04G0136-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Growth Differentiation Factor 5 ELISA kit

E04G0136-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Fibroblast growth factor 5 ELISA kit

E03F0380-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Fibroblast growth factor 5 ELISA kit

E03F0380-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Fibroblast growth factor 5 ELISA kit

E03F0380-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Fibroblast growth factor 5 ELISA kit

E07F0380-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Fibroblast growth factor 5 ELISA kit

E07F0380-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Fibroblast growth factor 5 ELISA kit

E07F0380-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Growth Differentiation Factor 5 ELISA kit

E07G0136-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Growth Differentiation Factor 5 ELISA kit

E07G0136-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Growth Differentiation Factor 5 ELISA kit

E07G0136-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fibroblast growth factor 5 ELISA kit

E09F0380-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fibroblast growth factor 5 ELISA kit

E09F0380-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fibroblast growth factor 5 ELISA kit

E09F0380-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
In each mouse fashions, the event of PAH was linked to elevated interleukin-23 manufacturing, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a lack of angiopoietin-2. Collectively, these outcomes assist an essential function for NK cells within the regulation of pulmonary and systemic vascular perform and the pathogenesis of PAH.

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