Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

The flexibility to control the survival and demise of a cell is paramount all through the lifespan of a multicellular organism. Apoptosis, a foremost physiological type of programmed cell demise, is regulated by the Bcl-2 household proteins which are both pro-apoptotic or pro-survival.
The in vivo features of distinct Bcl-2 members of the family are largely unmasked by genetically engineered murine fashions. Mcl-1 is likely one of the two Bcl-2 like pro-survival genes whose germline deletion causes embryonic lethality in mice.
Its requisite for the survival of a broad vary of cell varieties has been additional unraveled by utilizing conditional and inducible deletion murine mannequin programs in numerous tissues or cell lineages and at distinct developmental levels. Furthermore, genetic mouse most cancers fashions have additionally demonstrated that Mcl-1 is crucial for the survival of a number of tumor varieties.
The MCL-1 locus is often amplified throughout numerous most cancers varieties in people. Small molecule inhibitors with excessive affinity and specificity to human MCL-1 have been developed and explored for the therapy of sure cancers. To facilitate the pre-clinical research of MCL-1 in most cancers and different illnesses, transgenic mouse fashions over-expressing human MCL-1 in addition to humanized MCL-1 mouse fashions have been lately engineered.
This overview discusses the present advances in understanding the physiological roles of Mcl-1 based mostly on research utilizing genetic murine fashions and its essential implications in pathology and therapy of human illnesses.

Human B Lymphomas Reveal Their Secrets and techniques By way of Genetic Mouse Fashions

Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and symbolize the sixth most cancers worldwide and probably the most frequent blood most cancers. The vast majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal heart (GC) skilled mature B cells.
GCs are transient buildings that type in lymphoid organs in response to antigen publicity of naive B cells, and the place B cell receptor (BCR) affinity maturation happens to advertise B cell differentiation into reminiscence B and plasma cells producing high-affinity antibodies.
Genomic instability related to the somatic hypermutation (SHM) and class-switch recombination (CSR) processes throughout GC transit improve susceptibility to malignant transformation. Most B cell differentiation steps within the GC are on the origin of frequent B cell malignant entities, specifically Follicular Lymphoma (FL) and GCB diffuse massive B cell lymphomas (GCB-DLBCL).
Over the previous decade, massive sequencing efforts have offered an important enhance within the identification of candidate oncogenes and tumor suppressors concerned in FL and DLBCL oncogenesis. Mouse fashions have been instrumental to precisely mimic in vivo lymphoma-specific mutations and interrogate their regular perform within the GC context and their oncogenic perform resulting in lymphoma onset.
The restricted entry of biopsies throughout the initiating steps of the illness, the mobile and (epi)genetic heterogeneity of particular person tumors throughout and inside sufferers linked to perturbed dynamics of GC ecosystems make the event of genetically engineered mouse fashions essential to decipher lymphomagenesis and illness development and ultimately to check the consequences of novel focused therapies.
On this overview, we offer an summary of a few of the essential genetically engineered mouse fashions which have been developed to recapitulate lymphoma-associated (epi)genetic alterations of two frequent GC-derived lymphoma entities: FL and GCB-DLCBL and describe how these mouse fashions have improved our data of the molecular processes supporting GC B cell transformation.

Benefits of patient-derived orthotopic mouse fashions and genetic reporters for growing fluorescence-guided surgical procedure.

Fluorescence-guided surgical procedure can improve the surgeon’s potential to realize a whole oncologic resection. There are a selection of tumor-specific probes being developed with many preclinical mouse fashions to judge their efficacy.
The present overview discusses the completely different preclinical mouse fashions within the setting of probe analysis and highlights some great benefits of patient-derived orthotopic xenografts (PDOX) mouse fashions and genetic reporters to develop fluorescence-guided surgical procedure.
Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Modifying out 5 Serpina1 paralogs to create a mouse mannequin of genetic emphysema.

Continual obstructive pulmonary illness impacts 10% of the worldwide inhabitants, and the main genetic trigger is α-1 antitrypsin (AAT) deficiency. Because of the complexity of the murine locus, which incorporates as much as six Serpina1 paralogs, no genetic animal mannequin of the illness has been efficiently generated till now. Right here we create a quintuple Serpina1a-e knockout utilizing CRISPR/Cas9-mediated genome enhancing.
The phenotype recapitulates the human illness phenotype, i.e., absence of hepatic and circulating AAT interprets functionally to a decreased capability to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which might be induced in youthful mice by a lipopolysaccharide problem.
This mouse fashions not solely AAT deficiency but in addition emphysema and is a related genetic mannequin and never one based mostly on developmental impairment of alveolarization or elastase administration. We anticipate that this distinctive mannequin shall be extremely related not solely to the preclinical growth of therapeutics for AAT deficiency, but in addition to emphysema and smoking analysis.

Exome sequencing of the TCL1 mouse mannequin for CLL reveals genetic heterogeneity and dynamics throughout illness growth.

The TCL1 mouse mannequin is extensively used to review pathophysiology, clonal evolution, and drug sensitivity or resistance of persistent lymphocytic leukemia (CLL). By performing entire exome sequencing, we current the genetic panorama of major tumors from TCL1 mice and of TCL1 tumors serially transplanted into wild-type recipients to imitate clonal evolution.
We present that just like CLL sufferers, mutations in mice are ceaselessly subclonal and heterogenous amongst completely different major TCL1 mice. We additional describe that this molecular heterogeneity mirrors heterogenous illness traits corresponding to organ infiltration or CLL dependent T cell skewing. Just like human CLL, we additional noticed the prevalence of novel mutations and structural variations throughout clonal evolution and located plasticity within the growth of B cell receptor particular subclones.
Thus, our outcomes uncover that the genetic complexity, pathway dependence and clonal dynamics in mouse CLL are in related settlement to human CLL, and they’re essential to think about in future analysis utilizing the TCL1 mouse for learning CLL.

Spontaneous pulmonary hypertension in geneticmouse fashions of pure killer cell deficiency.

Pure Killer (NK) cells are cytotoxic innate lymphoid cells with a longtime function within the regulation of vascular construction in being pregnant and most cancers. Impaired NK cell perform has been recognized in sufferers with pulmonary arterial hypertension (PAH), a illness of obstructive vascular reworking within the lungs, in addition to in a number of rodent fashions of illness.
Nonetheless, the exact contribution of NK cell impairment to the initiation and development of PAH stays unknown. Right here we report the event of spontaneous pulmonary hypertension in two impartial genetic fashions of NK cell dysfunction, together with Nfil3-/- mice, that are poor in NK cells because of the absence of the NFIL3 transcription issue, and Ncr1-Gfp mice, which lack the NK activating receptor NKp46.
Mouse fashions of NK insufficiency exhibited elevated proper ventricular systolic stress and muscularization of the pulmonary arteries within the absence of elevated left ventricular finish diastolic stress, indicating that the event of pulmonary hypertension was not secondary to left coronary heart dysfunction.
In circumstances of extreme NK cell impairment or loss, a subset of mice didn’t develop pulmonary hypertension and as an alternative exhibited decreased systemic blood stress, demonstrating an extension of vascular abnormalities past the pulmonary circulation into the systemic vasculature.

Wnt-3a GMP, CF

PR15121CF 10 ug
EUR 649

L Wnt-3A cells

S0011001 One Frozen vial
EUR 455

Protein Wnt-3a Polyclonal Antibody

42596-100ul 100ul
EUR 333

Human Protein Wnt-3a (WNT3A)

1-CSB-EP026136HU
  • EUR 437.00
  • EUR 238.00
  • EUR 1544.00
  • EUR 653.00
  • EUR 1029.00
  • EUR 296.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 43.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Protein Wnt-3a(WNT3A) expressed in E.coli

Mouse Protein Wnt-3a (Wnt3a)

1-CSB-EP026136MO
  • EUR 437.00
  • EUR 238.00
  • EUR 1544.00
  • EUR 653.00
  • EUR 1029.00
  • EUR 296.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 40.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Protein Wnt-3a(Wnt3a) expressed in E.coli

Human Protein Wnt-3a (WNT3A)

1-CSB-RP155494h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 41.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Protein Wnt-3a(WNT3A),partial expressed in E.coli

Protein Wnt-3a (WNT3A) Antibody

abx218011-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Protein Wnt-3a (WNT3A) Antibody

abx224220-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

Protein Wnt-3a Antibody (Biotin)

20-abx105841
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protein Wnt-3a Antibody (FITC)

20-abx107257
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protein Wnt-3a Antibody (HRP)

20-abx108677
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protein Wnt-3a (WNT3A) Antibody

abx117009-100ug 100 ug
EUR 467
  • Shipped within 5-10 working days.

Protein Wnt-3a (WNT3A) Antibody

20-abx136135
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protein Wnt-3a (WNT3A) Antibody

20-abx000791
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Wnt Family Member 3A (WNT3A) Antibody

20-abx211813
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Wnt Family Member 3A (WNT3A) Antibody

20-abx211920
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protein Wnt-3a Polyclonal Conjugated Antibody

C42596 100ul
EUR 397

Wnt-C59

A8685-5 5 mg
EUR 148
Description: Wnt-C59 is a selective inhibitor of Wnt signaling with IC50 value of 74 pM [1].

Wnt Antagonist, C59

2063-5
EUR 359

Human Protein Wnt-3a(WNT3A) ELISA kit

CSB-EL026136HU-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a (WNT3A) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Protein Wnt-3a(WNT3A) ELISA kit

1-CSB-EL026136HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a(WNT3A) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Protein Wnt-3a(WNT3A) ELISA kit

CSB-EL026136MO-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a (WNT3A) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Protein Wnt-3a(WNT3A) ELISA kit

1-CSB-EL026136MO
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a(WNT3A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Protein Wnt-3a (WNT3A) ELISA Kit

abx255085-96tests 96 tests
EUR 746
  • Shipped within 5-12 working days.

Human Protein Wnt-3a (WNT3A) ELISA Kit

abx251482-96tests 96 tests
EUR 746
  • Shipped within 5-12 working days.

ELISA kit for Mouse Protein Wnt-3a

EK4364 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Protein Wnt-3a

EK4365 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse Wnt3a/ Protein Wnt-3a ELISA Kit

E1594Mo 1 Kit
EUR 571

Human WNT3A/ Protein Wnt-3a ELISA Kit

E2688Hu 1 Kit
EUR 571

Human WNT3A(Protein Wnt-3a) ELISA Kit

EH2146 96T
EUR 567.6
  • Detection range: 1.57-100 ng/ml
  • Uniprot ID: P56704
  • Alias: WNT3A/MGC119418/MGC119419/MGC119420/protein Wnt-3a/wingless-type MMTV integration site family, member 3A
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Mouse Protein Wnt- 3a, Wnt3a ELISA KIT

ELI-06995m 96 Tests
EUR 865

Chicken Protein Wnt- 3a, WNT3A ELISA KIT

ELI-06996c 96 Tests
EUR 928

Human Protein Wnt- 3a, WNT3A ELISA KIT

ELI-06997h 96 Tests
EUR 824

Human Protein Wnt-3a (WNT3A) ELISA Kit

abx570841-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.

Mouse Protein Wnt-3a (WNT3A) ELISA Kit

abx575000-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.

Chicken Protein Wnt-3a (WNT3A) ELISA Kit

abx519656-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Mouse Wnt3a(Protein Wnt-3a) ELISA Kit

EM0737 96T
EUR 567.6
  • Detection range: 0.312-20 ng/ml
  • Uniprot ID: P27467
  • Alias: Wnt3a/WNT3A/MGC119418/MGC119419/MGC119420/protein Wnt-3a/wingless-type MMTV integration site family, member 3A
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

5-HT-3A Antibody

34152-100ul 100ul
EUR 252

5-HT-3A Antibody

34152-50ul 50ul
EUR 187

5-HT-3A Antibody

DF3502 200ul
EUR 304
Description: 5-HT-3A Antibody detects endogenous levels of total 5-HT-3A.

5- HT- 3A Antibody

ABD3502 100 ug
EUR 438

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-48T 48T
EUR 332
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during em
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-5platesof96wells 5 plates of 96 wells
EUR 2115
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during em
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Protein Wnt-3a (WNT3A)

KTE70008-96T 96T
EUR 539
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during em
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Protein Wnt-3a (WNT3A)

KTE60023-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Growth Factor Set IV, StemBoost?

K426-5
EUR 854

Human Growth Differentiation Factor 5 (GDF-5) Antibody

30011-05111 150 ug
EUR 261

Fetal Bovine Serum,Low IgG , < 5 ug/ml

F0710-050 500 ml
EUR 1198

Growth/differentiation factor 5 Polyclonal Antibody

42178-100ul 100ul
EUR 333

Mouse Growth/differentiation factor 5 (Gdf5)

1-CSB-EP009349MO
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 17.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx009268
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

abx026572-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

abx026572-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx006710
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx176717
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx176718
  • EUR 1302.00
  • EUR 620.00
  • 1 mg
  • 200 ug
  • Please enquire.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx103263
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx103264
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx123595
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx128010
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx128606
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx109840
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx172410
  • EUR 787.00
  • EUR 411.00
  • 1 mg
  • 200 ug
  • Please enquire.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx172684
  • EUR 718.00
  • EUR 384.00
  • 1 mg
  • 200 ug
  • Please enquire.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx172685
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug
  • Please enquire.

Growth Differentiation Factor 5 (GDF5) Antibody

abx031516-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

abx031516-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx320075
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Fibroblast Growth Factor 5 (FGF5) Antibody

abx233094-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

20-abx327566
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Fibroblast Growth Factor 5 (FGF5) Antibody

20-abx323550
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Growth Differentiation Factor 5 (GDF5) Antibody

abx432738-200ul 200 ul
EUR 286
  • Shipped within 1-3 working days.

Recombinant Fibroblast Growth Factor 5 (FGF5)

4-RPA357Hu01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q8NF90
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 30.9kDa
  • Isoelectric Point: 10.6
Description: Recombinant Human Fibroblast Growth Factor 5 expressed in: E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Hu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P43026
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 15.1kDa
  • Isoelectric Point: 6.5
Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Hu02
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P43026
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 50.2kDa
  • Isoelectric Point: 9.8
Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli

Recombinant Growth Differentiation Factor 5 (GDF5)

4-RPC110Mu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P43027
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 21.6kDa
  • Isoelectric Point: Inquire
Description: Recombinant Mouse Growth Differentiation Factor 5 expressed in: E.coli

5-Hydroxytryptamine Receptor 3A (5-HT3A) Antibody

20-abx013887
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Epidermal Growth Factor (EGF), human recombinant

P1008-.5 500 µg
EUR 313
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR.

Epidermal Growth Factor (EGF), human recombinant

P1008-5 5 mg
EUR 1372
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR.

Wnt3a ELISA Kit| Mouse Protein Wnt-3a ELISA Kit

EF013348 96 Tests
EUR 689

Recombinant Human Protein Wnt-3a Protein, His, E.coli-100ug

QP8838-ec-100ug 100ug
EUR 408

Recombinant Human Protein Wnt-3a Protein, His, E.coli-10ug

QP8838-ec-10ug 10ug
EUR 200

Recombinant Human Protein Wnt-3a Protein, His, E.coli-1mg

QP8838-ec-1mg 1mg
EUR 1632

Recombinant Human Protein Wnt-3a Protein, His, E.coli-200ug

QP8838-ec-200ug 200ug
EUR 634

Recombinant Human Protein Wnt-3a Protein, His, E.coli-500ug

QP8838-ec-500ug 500ug
EUR 1060

Recombinant Human Protein Wnt-3a Protein, His, E.coli-50ug

QP8838-ec-50ug 50ug
EUR 263

5-HT-3A Blocking Peptide

DF3502-BP 1mg
EUR 195

5-HT-3A Conjugated Antibody

C34152 100ul
EUR 397

Epidermal Growth Factor Receptor Peptide (985-996)

A1021-5 5 mg
EUR 189
Description: EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by the binding of its specific ligands, including epidermal growth factor and transforming growth factor ?. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity.

Insulin-like Growth Factor I (57-70)

5-01399 4 x 5mg Ask for price

Insulin-Like Growth Factor II (69-84)

5-01400 4 x 1mg Ask for price

Platelet-Derived Growth Factor Receptor Substrate 2

5-01775 4 x 1mg Ask for price

Prepro-Nerve Growth Factor (99-115) (mouse)

5-01801 4 x 1mg Ask for price

Epidermal Growth Factor Receptor Peptide (985-996)

5-01114 4 x 1mg Ask for price
In each mouse fashions, the event of PAH was linked to elevated interleukin-23 manufacturing, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a lack of angiopoietin-2. Collectively, these outcomes assist an essential function for NK cells within the regulation of pulmonary and systemic vascular perform and the pathogenesis of PAH.

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