Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

The flexibility to control the survival and demise of a cell is paramount all through the lifespan of a multicellular organism. Apoptosis, a foremost physiological type of programmed cell demise, is regulated by the Bcl-2 household proteins which are both pro-apoptotic or pro-survival.
The in vivo features of distinct Bcl-2 members of the family are largely unmasked by genetically engineered murine fashions. Mcl-1 is likely one of the two Bcl-2 like pro-survival genes whose germline deletion causes embryonic lethality in mice.
Its requisite for the survival of a broad vary of cell varieties has been additional unraveled by utilizing conditional and inducible deletion murine mannequin programs in numerous tissues or cell lineages and at distinct developmental levels. Furthermore, genetic mouse most cancers fashions have additionally demonstrated that Mcl-1 is crucial for the survival of a number of tumor varieties.
The MCL-1 locus is often amplified throughout numerous most cancers varieties in people. Small molecule inhibitors with excessive affinity and specificity to human MCL-1 have been developed and explored for the therapy of sure cancers. To facilitate the pre-clinical research of MCL-1 in most cancers and different illnesses, transgenic mouse fashions over-expressing human MCL-1 in addition to humanized MCL-1 mouse fashions have been lately engineered.
This overview discusses the present advances in understanding the physiological roles of Mcl-1 based mostly on research utilizing genetic murine fashions and its essential implications in pathology and therapy of human illnesses.

Human B Lymphomas Reveal Their Secrets and techniques By way of Genetic Mouse Fashions

Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and symbolize the sixth most cancers worldwide and probably the most frequent blood most cancers. The vast majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal heart (GC) skilled mature B cells.
GCs are transient buildings that type in lymphoid organs in response to antigen publicity of naive B cells, and the place B cell receptor (BCR) affinity maturation happens to advertise B cell differentiation into reminiscence B and plasma cells producing high-affinity antibodies.
Genomic instability related to the somatic hypermutation (SHM) and class-switch recombination (CSR) processes throughout GC transit improve susceptibility to malignant transformation. Most B cell differentiation steps within the GC are on the origin of frequent B cell malignant entities, specifically Follicular Lymphoma (FL) and GCB diffuse massive B cell lymphomas (GCB-DLBCL).
Over the previous decade, massive sequencing efforts have offered an important enhance within the identification of candidate oncogenes and tumor suppressors concerned in FL and DLBCL oncogenesis. Mouse fashions have been instrumental to precisely mimic in vivo lymphoma-specific mutations and interrogate their regular perform within the GC context and their oncogenic perform resulting in lymphoma onset.
The restricted entry of biopsies throughout the initiating steps of the illness, the mobile and (epi)genetic heterogeneity of particular person tumors throughout and inside sufferers linked to perturbed dynamics of GC ecosystems make the event of genetically engineered mouse fashions essential to decipher lymphomagenesis and illness development and ultimately to check the consequences of novel focused therapies.
On this overview, we offer an summary of a few of the essential genetically engineered mouse fashions which have been developed to recapitulate lymphoma-associated (epi)genetic alterations of two frequent GC-derived lymphoma entities: FL and GCB-DLCBL and describe how these mouse fashions have improved our data of the molecular processes supporting GC B cell transformation.

Benefits of patient-derived orthotopic mouse fashions and genetic reporters for growing fluorescence-guided surgical procedure.

Fluorescence-guided surgical procedure can improve the surgeon’s potential to realize a whole oncologic resection. There are a selection of tumor-specific probes being developed with many preclinical mouse fashions to judge their efficacy.
The present overview discusses the completely different preclinical mouse fashions within the setting of probe analysis and highlights some great benefits of patient-derived orthotopic xenografts (PDOX) mouse fashions and genetic reporters to develop fluorescence-guided surgical procedure.
Physiological Functions of Mcl-1: Insights From Genetic Mouse Models

Modifying out 5 Serpina1 paralogs to create a mouse mannequin of genetic emphysema.

Continual obstructive pulmonary illness impacts 10% of the worldwide inhabitants, and the main genetic trigger is α-1 antitrypsin (AAT) deficiency. Because of the complexity of the murine locus, which incorporates as much as six Serpina1 paralogs, no genetic animal mannequin of the illness has been efficiently generated till now. Right here we create a quintuple Serpina1a-e knockout utilizing CRISPR/Cas9-mediated genome enhancing.
The phenotype recapitulates the human illness phenotype, i.e., absence of hepatic and circulating AAT interprets functionally to a decreased capability to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which might be induced in youthful mice by a lipopolysaccharide problem.
This mouse fashions not solely AAT deficiency but in addition emphysema and is a related genetic mannequin and never one based mostly on developmental impairment of alveolarization or elastase administration. We anticipate that this distinctive mannequin shall be extremely related not solely to the preclinical growth of therapeutics for AAT deficiency, but in addition to emphysema and smoking analysis.

Exome sequencing of the TCL1 mouse mannequin for CLL reveals genetic heterogeneity and dynamics throughout illness growth.

The TCL1 mouse mannequin is extensively used to review pathophysiology, clonal evolution, and drug sensitivity or resistance of persistent lymphocytic leukemia (CLL). By performing entire exome sequencing, we current the genetic panorama of major tumors from TCL1 mice and of TCL1 tumors serially transplanted into wild-type recipients to imitate clonal evolution.
We present that just like CLL sufferers, mutations in mice are ceaselessly subclonal and heterogenous amongst completely different major TCL1 mice. We additional describe that this molecular heterogeneity mirrors heterogenous illness traits corresponding to organ infiltration or CLL dependent T cell skewing. Just like human CLL, we additional noticed the prevalence of novel mutations and structural variations throughout clonal evolution and located plasticity within the growth of B cell receptor particular subclones.
Thus, our outcomes uncover that the genetic complexity, pathway dependence and clonal dynamics in mouse CLL are in related settlement to human CLL, and they’re essential to think about in future analysis utilizing the TCL1 mouse for learning CLL.

Spontaneous pulmonary hypertension in geneticmouse fashions of pure killer cell deficiency.

Pure Killer (NK) cells are cytotoxic innate lymphoid cells with a longtime function within the regulation of vascular construction in being pregnant and most cancers. Impaired NK cell perform has been recognized in sufferers with pulmonary arterial hypertension (PAH), a illness of obstructive vascular reworking within the lungs, in addition to in a number of rodent fashions of illness.
Nonetheless, the exact contribution of NK cell impairment to the initiation and development of PAH stays unknown. Right here we report the event of spontaneous pulmonary hypertension in two impartial genetic fashions of NK cell dysfunction, together with Nfil3-/- mice, that are poor in NK cells because of the absence of the NFIL3 transcription issue, and Ncr1-Gfp mice, which lack the NK activating receptor NKp46.
Mouse fashions of NK insufficiency exhibited elevated proper ventricular systolic stress and muscularization of the pulmonary arteries within the absence of elevated left ventricular finish diastolic stress, indicating that the event of pulmonary hypertension was not secondary to left coronary heart dysfunction.
In circumstances of extreme NK cell impairment or loss, a subset of mice didn’t develop pulmonary hypertension and as an alternative exhibited decreased systemic blood stress, demonstrating an extension of vascular abnormalities past the pulmonary circulation into the systemic vasculature.

Mouse Fibroblast Growth Factor 5 ELISA Kit

MBS7256031-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Fibroblast Growth Factor 5 ELISA Kit

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Mouse Fibroblast Growth Factor 5 ELISA Kit

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Mouse Fibroblast Growth Factor 5 ELISA Kit

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Mouse Fibroblast growth factor 5 ELISA Kit

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Mouse Fibroblast growth factor 5 ELISA Kit

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Mouse Fibroblast growth factor 5 ELISA Kit

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EUR 2220

Mouse Fibroblast growth factor 5 ELISA Kit

MBS2880645-96StripWells 96-Strip-Wells
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Mouse Growth/differentiation factor 5 (Gdf5)

1-CSB-EP009349MO
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Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

CSB-EP008632MO 9462 mg Ask for price

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

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Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

MBS959020-002mgBaculovirus 0.02mg(Baculovirus)
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

MBS959020-002mgEColi 0.02mg(E-Coli)
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

MBS959020-002mgYeast 0.02mg(Yeast)
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

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Recombinant Mouse Fibroblast growth factor 5 (Fgf5)

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Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

abx512829-96tests 96 tests
EUR 801.6

Mouse Fibroblast growth factor 5(FGF5) Elisa kit

EK730847 96 Wells
EUR 0.72

Mouse Fibroblast growth factor 5(FGF5) ELISA kit

EKC36871-48T 48T
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Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

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Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

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Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

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EUR 882.4

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

AE43665MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

AE43665MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5(FGF5) ELISA kit

CSB-EL008632MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5 (FGF5) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Fibroblast growth factor 5(FGF5) ELISA kit

1-CSB-EL008632MO
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Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5(FGF5) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Fgf5 / Fibroblast growth factor 5 ELISA Kit

E0397m 96T
EUR 776

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT

E2072Mo-1096T 10*96T
EUR 4122

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT

E2072Mo-48wells 48 wells
EUR 300

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT

E2072Mo-596T 5*96T
EUR 2061

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT

E2072Mo-96wells 96 wells
EUR 458

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

EKN52233-48T 48T
EUR 384.3

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

EKN52233-5x96T 5x96T
EUR 2607.75

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit

EKN52233-96T 96T
EUR 549

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

RK06732 96T
EUR 280

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

AE43665MO-48T 48T
EUR 325
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

AE43665MO-96T 96T
EUR 610
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS931255-10x96StripWells 10x96-Strip-Wells
EUR 5575

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS931255-24StripWellsLIMIT1 24-Strip-Wells(LIMIT1)
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Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS931255-48StripWells 48-Strip-Wells
EUR 545

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS931255-5x96StripWells 5x96-Strip-Wells
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Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS931255-96StripWells 96-Strip-Wells
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Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS1604966-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS1604966-48StripWells 48-Strip-Wells
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Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS1604966-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit

MBS1604966-96StripWells 96-Strip-Wells
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

MBS2803671-10x96StripWells 10x96-Strip-Wells
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

MBS2803671-48StripWells 48-Strip-Wells
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

MBS2803671-5x96StripWells 5x96-Strip-Wells
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit

MBS2803671-96StripWells 96-Strip-Wells
EUR 730

Recombinant Mouse Growth/differentiation factor 5

MBS718033-002mgEColi 0.02mg(E-Coli)
EUR 320

Recombinant Mouse Growth/differentiation factor 5

MBS718033-01mgEColi 0.1mg(E-Coli)
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Recombinant Mouse Growth/differentiation factor 5

MBS718033-1mgEColi 1mg(E-Coli)
EUR 1925

Recombinant Mouse Growth/differentiation factor 5

MBS718033-5x1mgEColi 5x1mg(E-Coli)
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Recombinant mouse Growth/differentiation factor 5

MBS9420263-002mg 0.02mg
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Recombinant mouse Growth/differentiation factor 5

MBS9420263-01mg 0.1mg
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Recombinant mouse Growth/differentiation factor 5

MBS9420263-1mg 1mg
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Recombinant mouse Growth/differentiation factor 5

MBS9420263-5x1mg 5x1mg
EUR 11205

Fibroblast growth factor 5

AP89391 1mg
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Fibroblast growth factor 5

AP82670 1mg
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Fibroblast growth factor 5

AP82956 1mg
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Fibroblast growth factor 5

AP83077 1mg
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Fibroblast growth factor 5

AP83491 1mg
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Mouse Fibroblast Growth Factor 5, FGF5 GENLISA ELISA

KLM2072 1 x 96 wells
EUR 341

Mouse Growth Differentiation Factor 5 CLIA Kit

MBS8426250-INQUIRE INQUIRE Ask for price

Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit

E01A21934 96T
EUR 700
Description: ELISA

Mouse Growth Differentiation Factor 5 ELISA kit

E01A22208 96T
EUR 700
Description: ELISA

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA kit

E03G0136-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Growth Differentiation Factor 5 ELISA Kit

MBS020589-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Growth Differentiation Factor 5 ELISA Kit

MBS020589-48StripWells 48-Strip-Wells
EUR 550

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EUR 3420

Mouse Growth Differentiation Factor 5 ELISA Kit

MBS020589-96StripWells 96-Strip-Wells
EUR 765

Mouse Growth Differentiation Factor 5 ELISA Kit

IMSGDF5KT each
EUR 890
Description: Mouse Growth Differentiation Factor 5 ELISA Kit

Mouse Growth Differentiation Factor 5 ELISA Kit

MBS728393-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Growth Differentiation Factor 5 ELISA Kit

MBS728393-48StripWells 48-Strip-Wells
EUR 485

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Mouse Growth/differentiation Factor 5 ELISA Kit

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EUR 340

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EUR 2045

Mouse Growth/differentiation Factor 5 ELISA Kit

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Mouse Growth Differentiation Factor 5 ELISA Kit

MBS8420609-1Kit 1Kit
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Mouse Growth/differentiation factor 5 ELISA Kit

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Mouse Growth/differentiation factor 5 ELISA Kit

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EUR 2220

Mouse Growth/differentiation factor 5 ELISA Kit

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EUR 520

Mouse Growth Differentiation Factor 5 (GDF5) Protein

20-abx066946
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Mouse Growth Differentiation Factor 5 (GDF5) Protein

abx066946-100g 100 µg
EUR 475

Mouse Growth Differentiation Factor 5 (GDF5) Protein

abx066946-10g 10 µg
EUR 200

Mouse Growth Differentiation Factor 5 (GDF5) Protein

abx066946-50g 50 µg
EUR 337.5

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP)

MBS6131288-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP)

MBS6131288-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP)

MBS6378515-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP)

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EUR 3990

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE)

MBS6378525-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE)

MBS6378525-5x01mL 5x0.1mL
EUR 3990

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE)

MBS6157803-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE)

MBS6157803-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC

MBS6136591-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC

MBS6136591-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC

MBS6378516-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC

MBS6378516-5x01mL 5x0.1mL
EUR 3990

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC)

MBS6378518-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC)

MBS6378518-5x01mL 5x0.1mL
EUR 3990

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP)

MBS6378519-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP)

MBS6378519-5x01mL 5x0.1mL
EUR 3990

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC)

MBS6147197-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC)

MBS6147197-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP)

MBS6152500-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP)

MBS6152500-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin)

MBS6141894-01mL 0.1(mL
EUR 875

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin)

MBS6141894-5x01mL 5x0.1mL
EUR 3800

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin)

MBS6378517-01mL 0.1mL
EUR 920

FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin)

MBS6378517-5x01mL 5x0.1mL
EUR 3990

Fgf5 (GFP-tagged) - Mouse fibroblast growth factor 5 (Fgf5)

MG203484 10 µg Ask for price

Fgf5 (untagged ORF) - Rat fibroblast growth factor 5 (Fgf5), (10 ug)

RN215452 10 µg Ask for price

Growth and Differentiation factor 5 Mouse Recombinant

rAP-0397 Inquiry Ask for price

Recombinant Mouse Growth and Differentiation factor 5

cyt-941-10g 10µg
EUR 60

Recombinant Mouse Growth and Differentiation factor 5

cyt-941-1mg 1mg
EUR 1350

Recombinant Mouse Growth and Differentiation factor 5

cyt-941-50g 50µg
EUR 145

Recombinant Mouse Growth and Differentiation factor 5

MBS141101-001mg 0.01mg
EUR 240

Recombinant Mouse Growth and Differentiation factor 5

MBS141101-005mg 0.05mg
EUR 310

Recombinant Mouse Growth and Differentiation factor 5

MBS141101-1mg 1mg
EUR 1515

Recombinant Mouse Growth and Differentiation factor 5

MBS141101-5x1mg 5x1mg
EUR 6485

Mouse Heparin binding Epidermal Growth Factor like Growth Factor ELISA kit

E01A22478 96T
EUR 700
Description: ELISA

Mouse Heparin binding Epidermal Growth Factor like Growth Factor ELISA kit

E03H0038-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Heparin binding Epidermal Growth Factor like Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Heparin binding Epidermal Growth Factor like Growth Factor ELISA kit

E03H0038-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Heparin binding Epidermal Growth Factor like Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Heparin binding Epidermal Growth Factor like Growth Factor ELISA kit

E03H0038-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Heparin binding Epidermal Growth Factor like Growth Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Heparin Binding Epidermal Growth Factor Like Growth Factor ELISA Kit

IMSHBEGFKT each
EUR 522
Description: Mouse Heparin Binding Epidermal Growth Factor Like Growth Factor ELISA Kit

Recombinant Mouse Growth/differentiation factor 5(Gdf5)

AP70328 1mg
EUR 2826

Recombinant Mouse Growth/differentiation factor 5 (Gdf5)

CSB-EP009349MO 1240 mg Ask for price

Mouse Heparin-binding Epidermal Growth Factor-like Growth Factor CLIA Kit

MBS8426283-INQUIRE INQUIRE Ask for price

Mouse Growth Differentiation Factor 5 (GDF5) CLIA Kit

20-abx190566
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Growth Differentiation Factor 5 (GDF5) CLIA Kit

abx197085-96tests 96 tests
EUR 990

Mouse Growth Differentiation Factor 5 (GDF5) CLIA Kit

EKN50974-48T 48T
EUR 426.72
In each mouse fashions, the event of PAH was linked to elevated interleukin-23 manufacturing, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a lack of angiopoietin-2. Collectively, these outcomes assist an essential function for NK cells within the regulation of pulmonary and systemic vascular perform and the pathogenesis of PAH.

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