
Physiological Functions of Mcl-1: Insights From Genetic Mouse Models
Danielle
- 0
The flexibility to control the survival and demise of a cell is paramount all through the lifespan of a multicellular organism. Apoptosis, a foremost physiological type of programmed cell demise, is regulated by the Bcl-2 household proteins which are both pro-apoptotic or pro-survival.
The in vivo features of distinct Bcl-2 members of the family are largely unmasked by genetically engineered murine fashions. Mcl-1 is likely one of the two Bcl-2 like pro-survival genes whose germline deletion causes embryonic lethality in mice.
Its requisite for the survival of a broad vary of cell varieties has been additional unraveled by utilizing conditional and inducible deletion murine mannequin programs in numerous tissues or cell lineages and at distinct developmental levels. Furthermore, genetic mouse most cancers fashions have additionally demonstrated that Mcl-1 is crucial for the survival of a number of tumor varieties.
The MCL-1 locus is often amplified throughout numerous most cancers varieties in people. Small molecule inhibitors with excessive affinity and specificity to human MCL-1 have been developed and explored for the therapy of sure cancers. To facilitate the pre-clinical research of MCL-1 in most cancers and different illnesses, transgenic mouse fashions over-expressing human MCL-1 in addition to humanized MCL-1 mouse fashions have been lately engineered.
This overview discusses the present advances in understanding the physiological roles of Mcl-1 based mostly on research utilizing genetic murine fashions and its essential implications in pathology and therapy of human illnesses.
Human B Lymphomas Reveal Their Secrets and techniques By way of Genetic Mouse Fashions
Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and symbolize the sixth most cancers worldwide and probably the most frequent blood most cancers. The vast majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal heart (GC) skilled mature B cells.
GCs are transient buildings that type in lymphoid organs in response to antigen publicity of naive B cells, and the place B cell receptor (BCR) affinity maturation happens to advertise B cell differentiation into reminiscence B and plasma cells producing high-affinity antibodies.
Genomic instability related to the somatic hypermutation (SHM) and class-switch recombination (CSR) processes throughout GC transit improve susceptibility to malignant transformation. Most B cell differentiation steps within the GC are on the origin of frequent B cell malignant entities, specifically Follicular Lymphoma (FL) and GCB diffuse massive B cell lymphomas (GCB-DLBCL).
Over the previous decade, massive sequencing efforts have offered an important enhance within the identification of candidate oncogenes and tumor suppressors concerned in FL and DLBCL oncogenesis. Mouse fashions have been instrumental to precisely mimic in vivo lymphoma-specific mutations and interrogate their regular perform within the GC context and their oncogenic perform resulting in lymphoma onset.
The restricted entry of biopsies throughout the initiating steps of the illness, the mobile and (epi)genetic heterogeneity of particular person tumors throughout and inside sufferers linked to perturbed dynamics of GC ecosystems make the event of genetically engineered mouse fashions essential to decipher lymphomagenesis and illness development and ultimately to check the consequences of novel focused therapies.
On this overview, we offer an summary of a few of the essential genetically engineered mouse fashions which have been developed to recapitulate lymphoma-associated (epi)genetic alterations of two frequent GC-derived lymphoma entities: FL and GCB-DLCBL and describe how these mouse fashions have improved our data of the molecular processes supporting GC B cell transformation.
Benefits of patient-derived orthotopic mouse fashions and genetic reporters for growing fluorescence-guided surgical procedure.
Fluorescence-guided surgical procedure can improve the surgeon’s potential to realize a whole oncologic resection. There are a selection of tumor-specific probes being developed with many preclinical mouse fashions to judge their efficacy.
The present overview discusses the completely different preclinical mouse fashions within the setting of probe analysis and highlights some great benefits of patient-derived orthotopic xenografts (PDOX) mouse fashions and genetic reporters to develop fluorescence-guided surgical procedure.

Modifying out 5 Serpina1 paralogs to create a mouse mannequin of genetic emphysema.
Continual obstructive pulmonary illness impacts 10% of the worldwide inhabitants, and the main genetic trigger is α-1 antitrypsin (AAT) deficiency. Because of the complexity of the murine locus, which incorporates as much as six Serpina1 paralogs, no genetic animal mannequin of the illness has been efficiently generated till now. Right here we create a quintuple Serpina1a-e knockout utilizing CRISPR/Cas9-mediated genome enhancing.
The phenotype recapitulates the human illness phenotype, i.e., absence of hepatic and circulating AAT interprets functionally to a decreased capability to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which might be induced in youthful mice by a lipopolysaccharide problem.
This mouse fashions not solely AAT deficiency but in addition emphysema and is a related genetic mannequin and never one based mostly on developmental impairment of alveolarization or elastase administration. We anticipate that this distinctive mannequin shall be extremely related not solely to the preclinical growth of therapeutics for AAT deficiency, but in addition to emphysema and smoking analysis.
Exome sequencing of the TCL1 mouse mannequin for CLL reveals genetic heterogeneity and dynamics throughout illness growth.
The TCL1 mouse mannequin is extensively used to review pathophysiology, clonal evolution, and drug sensitivity or resistance of persistent lymphocytic leukemia (CLL). By performing entire exome sequencing, we current the genetic panorama of major tumors from TCL1 mice and of TCL1 tumors serially transplanted into wild-type recipients to imitate clonal evolution.
We present that just like CLL sufferers, mutations in mice are ceaselessly subclonal and heterogenous amongst completely different major TCL1 mice. We additional describe that this molecular heterogeneity mirrors heterogenous illness traits corresponding to organ infiltration or CLL dependent T cell skewing. Just like human CLL, we additional noticed the prevalence of novel mutations and structural variations throughout clonal evolution and located plasticity within the growth of B cell receptor particular subclones.
Thus, our outcomes uncover that the genetic complexity, pathway dependence and clonal dynamics in mouse CLL are in related settlement to human CLL, and they’re essential to think about in future analysis utilizing the TCL1 mouse for learning CLL.
Spontaneous pulmonary hypertension in geneticmouse fashions of pure killer cell deficiency.
Pure Killer (NK) cells are cytotoxic innate lymphoid cells with a longtime function within the regulation of vascular construction in being pregnant and most cancers. Impaired NK cell perform has been recognized in sufferers with pulmonary arterial hypertension (PAH), a illness of obstructive vascular reworking within the lungs, in addition to in a number of rodent fashions of illness.
Nonetheless, the exact contribution of NK cell impairment to the initiation and development of PAH stays unknown. Right here we report the event of spontaneous pulmonary hypertension in two impartial genetic fashions of NK cell dysfunction, together with Nfil3-/- mice, that are poor in NK cells because of the absence of the NFIL3 transcription issue, and Ncr1-Gfp mice, which lack the NK activating receptor NKp46.
Mouse fashions of NK insufficiency exhibited elevated proper ventricular systolic stress and muscularization of the pulmonary arteries within the absence of elevated left ventricular finish diastolic stress, indicating that the event of pulmonary hypertension was not secondary to left coronary heart dysfunction.
In circumstances of extreme NK cell impairment or loss, a subset of mice didn’t develop pulmonary hypertension and as an alternative exhibited decreased systemic blood stress, demonstrating an extension of vascular abnormalities past the pulmonary circulation into the systemic vasculature.
Human Protein Wnt-3a (WNT3A) |
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1-CSB-EP026136HU | Cusabio |
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Description: Recombinant Human Protein Wnt-3a(WNT3A) expressed in E.coli |
Mouse Protein Wnt-3a (Wnt3a) |
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1-CSB-EP026136MO | Cusabio |
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Description: Recombinant Mouse Protein Wnt-3a(Wnt3a) expressed in E.coli |
Protein Wnt-3a Polyclonal Antibody |
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42596-100ul | SAB | 100ul | EUR 399.6 |
Protein Wnt-3a Antibody (HRP) |
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20-abx108677 | Abbexa |
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Protein Wnt-3a Antibody (Biotin) |
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20-abx105841 | Abbexa |
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Protein Wnt-3a Antibody (FITC) |
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20-abx107257 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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20-abx136135 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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abx117009-100ug | Abbexa | 100 ug | EUR 560.4 |
Protein Wnt-3a (WNT3A) Antibody |
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20-abx000791 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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abx224220-100ug | Abbexa | 100 ug | EUR 493.2 |
Protein Wnt-3a (WNT3A) Antibody |
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abx218011-100ug | Abbexa | 100 ug | EUR 526.8 |
Wnt-C59 |
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A8685-5 | ApexBio | 5 mg | EUR 177.6 |
Description: Wnt-C59 is a selective inhibitor of Wnt signaling with IC50 value of 74 pM [1]. |
Protein Wnt-3a Polyclonal Conjugated Antibody |
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C42596 | SAB | 100ul | EUR 476.4 |
Wnt Family Member 3A (WNT3A) Antibody |
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20-abx211813 | Abbexa |
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Wnt Family Member 3A (WNT3A) Antibody |
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20-abx211920 | Abbexa |
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Growth Medium 3A |
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60188 | BPS Bioscience | 500 ml | EUR 755 |
Description: This liquid Growth Medium is a complete medium optimized to culture select CHO and CHO-K1 cell lines. |
Wnt Antagonist, C59 |
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2063-5 | Biovision | each | EUR 430.8 |
Human Protein Wnt-3a(WNT3A) ELISA kit |
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CSB-EL026136HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a (WNT3A) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Protein Wnt-3a(WNT3A) ELISA kit |
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1-CSB-EL026136HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a(WNT3A) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Protein Wnt-3a(WNT3A) ELISA kit |
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CSB-EL026136MO-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a (WNT3A) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Protein Wnt-3a(WNT3A) ELISA kit |
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1-CSB-EL026136MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a(WNT3A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Wnt3a/ Protein Wnt-3a ELISA Kit |
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E1594Mo | Sunlong | 1 Kit | EUR 685.2 |
Mouse Wnt3a(Protein Wnt-3a) ELISA Kit |
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EM0737 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml |
ELISA kit for Mouse Protein Wnt-3a |
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EK4364 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids. |
ELISA kit for Human Protein Wnt-3a |
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EK4365 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids. |
Human WNT3A(Protein Wnt-3a) ELISA Kit |
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EH2146 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml |
Human Protein Wnt-3a (WNT3A) ELISA Kit |
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abx570841-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse Protein Wnt-3a (WNT3A) ELISA Kit |
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abx575000-96tests | Abbexa | 96 tests | EUR 801.6 |
Chicken Protein Wnt-3a (WNT3A) ELISA Kit |
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abx519656-96tests | Abbexa | 96 tests | EUR 1093.2 |
Human Protein Wnt-3a (WNT3A) ELISA Kit |
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abx251482-96tests | Abbexa | 96 tests | EUR 895.2 |
Mouse Protein Wnt-3a (WNT3A) ELISA Kit |
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abx255085-96tests | Abbexa | 96 tests | EUR 895.2 |
Human WNT3A/ Protein Wnt-3a ELISA Kit |
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E2688Hu | Sunlong | 1 Kit | EUR 685.2 |
Mouse Protein Wnt- 3a, Wnt3a ELISA KIT |
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ELI-06995m | Lifescience Market | 96 Tests | EUR 1038 |
Chicken Protein Wnt- 3a, WNT3A ELISA KIT |
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ELI-06996c | Lifescience Market | 96 Tests | EUR 1113.6 |
Human Protein Wnt- 3a, WNT3A ELISA KIT |
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ELI-06997h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse Protein Wnt-3a(WNT3A)ELISA Kit |
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YLA0005MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse Protein Wnt-3a(WNT3A)ELISA Kit |
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YLA0005MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
BD Transforming growth factor beta 1human 1 ug |
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354039 | Scientific Laboratory Supplies | EACH | EUR 279.3 |
BD Epidermal growth factor human recombinant 100 ug |
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354052 | Scientific Laboratory Supplies | EACH | EUR 204.06 |
ELISA kit for Human Protein Wnt-3a (WNT3A) |
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KTE60023-48T | Abbkine | 48T | EUR 424.8 |
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Protein Wnt-3a (WNT3A) |
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KTE60023-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2702.4 |
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Protein Wnt-3a (WNT3A) |
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KTE60023-96T | Abbkine | 96T | EUR 686.4 |
Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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KTE70008-48T | Abbkine | 48T | EUR 398.4 |
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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KTE70008-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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KTE70008-96T | Abbkine | 96T | EUR 646.8 |
Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
5-HT-3A Antibody |
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34152-100ul | SAB | 100ul | EUR 302.4 |
5-HT-3A Antibody |
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34152-50ul | SAB | 50ul | EUR 224.4 |
5- HT- 3A Antibody |
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ABD3502 | Lifescience Market | 100 ug | EUR 525.6 |
Growth Factor Set IV, StemBoost? |
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K426-5 | Biovision | each | EUR 1024.8 |
Human Growth Differentiation Factor 5 (GDF-5) Antibody |
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30011-05111 | AssayPro | 150 ug | EUR 313.2 |
Mouse Growth/differentiation factor 5 (Gdf5) |
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1-CSB-EP009349MO | Cusabio |
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Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli |
Growth/differentiation factor 5 Polyclonal Antibody |
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42178-100ul | SAB | 100ul | EUR 399.6 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx109840 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx103263 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx103264 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx172410 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx172684 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx172685 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx123595 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx128010 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx128606 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx006710 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx009268 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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abx026572-400ul | Abbexa | 400 ul | EUR 627.6 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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abx026572-80l | Abbexa | 80 µl | EUR 343.2 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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abx031516-400ul | Abbexa | 400 ul | EUR 627.6 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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abx031516-80l | Abbexa | 80 µl | EUR 343.2 |
Fibroblast Growth Factor 5 (FGF5) Antibody |
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abx233094-100ug | Abbexa | 100 ug | EUR 610.8 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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abx432738-200ul | Abbexa | 200 ul | EUR 343.2 |
Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx320075 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx323550 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx327566 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx176717 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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20-abx176718 | Abbexa |
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Recombinant Fibroblast Growth Factor 5 (FGF5) |
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4-RPA357Hu01 | Cloud-Clone |
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Description: Recombinant Human Fibroblast Growth Factor 5 expressed in: E.coli |
Recombinant Growth Differentiation Factor 5 (GDF5) |
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4-RPC110Hu01 | Cloud-Clone |
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Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli |
Recombinant Growth Differentiation Factor 5 (GDF5) |
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4-RPC110Hu02 | Cloud-Clone |
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Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli |
Recombinant Growth Differentiation Factor 5 (GDF5) |
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4-RPC110Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Growth Differentiation Factor 5 expressed in: E.coli |
Epidermal Growth Factor (EGF), human recombinant |
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P1008-.5 | ApexBio | 500 µg | EUR 375.6 |
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR. |
Epidermal Growth Factor (EGF), human recombinant |
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P1008-5 | ApexBio | 5 mg | EUR 1646.4 |
Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR. |
Wnt3a ELISA Kit| Mouse Protein Wnt-3a ELISA Kit |
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EF013348 | Lifescience Market | 96 Tests | EUR 826.8 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-100ug |
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QP8838-ec-100ug | EnQuireBio | 100ug | EUR 489.6 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-10ug |
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QP8838-ec-10ug | EnQuireBio | 10ug | EUR 240 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-1mg |
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QP8838-ec-1mg | EnQuireBio | 1mg | EUR 1958.4 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-200ug |
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QP8838-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-500ug |
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QP8838-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-50ug |
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QP8838-ec-50ug | EnQuireBio | 50ug | EUR 315.6 |
5-Hydroxytryptamine Receptor 3A (5-HT3A) Antibody |
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20-abx013887 | Abbexa |
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5-HT-3A Blocking Peptide |
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DF3502-BP | Affbiotech | 1mg | EUR 234 |
5-HT-3A Conjugated Antibody |
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C34152 | SAB | 100ul | EUR 476.4 |
Epidermal Growth Factor Receptor Peptide (985-996) |
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5-01114 | CHI Scientific | 4 x 1mg | Ask for price |
Insulin-like Growth Factor I (57-70) |
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5-01399 | CHI Scientific | 4 x 5mg | Ask for price |
Insulin-Like Growth Factor II (69-84) |
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5-01400 | CHI Scientific | 4 x 1mg | Ask for price |
Platelet-Derived Growth Factor Receptor Substrate 2 |
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5-01775 | CHI Scientific | 4 x 1mg | Ask for price |
Prepro-Nerve Growth Factor (99-115) (mouse) |
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5-01801 | CHI Scientific | 4 x 1mg | Ask for price |
Epidermal Growth Factor Receptor Peptide (985-996) |
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A1021-5 | ApexBio | 5 mg | EUR 226.8 |
Description: EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by the binding of its specific ligands, including epidermal growth factor and transforming growth factor ?. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. |
Sulfur 5 ug/g (5 PPM) for AA and ICP 100 grams in no.2 Diesel Fuel |
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SDFS-5-Y | Scientific Laboratory Supplies | 100ML | EUR 102.6 |
Human Fibroblast growth factor 5 ELISA kit |
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E01F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Fibroblast growth factor 5 ELISA kit |
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E01F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Fibroblast growth factor 5 ELISA kit |
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E01F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Growth Differentiation Factor 5 ELISA kit |
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E01G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Growth Differentiation Factor 5 ELISA kit |
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E01G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Growth Differentiation Factor 5 ELISA kit |
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E01G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Fibroblast growth factor 5 protein (FGF5) |
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1-CSB-RP095144h | Cusabio |
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Description: Recombinant Human Fibroblast growth factor 5 protein(FGF5) expressed in E.coli |
Goat Fibroblast growth factor 5 ELISA kit |
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E06F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Fibroblast growth factor 5 ELISA kit |
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E06F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Fibroblast growth factor 5 ELISA kit |
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E06F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Goat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Growth Differentiation Factor 5 ELISA kit |
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E06G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Growth Differentiation Factor 5 ELISA kit |
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E06G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Growth Differentiation Factor 5 ELISA kit |
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E06G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Goat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Fibroblast growth factor 5 ELISA kit |
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E02F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Fibroblast growth factor 5 ELISA kit |
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E02F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Fibroblast growth factor 5 ELISA kit |
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E02F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rat Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Growth Differentiation Factor 5 ELISA kit |
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E02G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Growth Differentiation Factor 5 ELISA kit |
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E02G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Growth Differentiation Factor 5 ELISA kit |
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E02G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rat Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Fibroblast growth factor 5 ELISA kit |
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E04F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Fibroblast growth factor 5 ELISA kit |
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E04F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Fibroblast growth factor 5 ELISA kit |
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E04F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rabbit Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Growth Differentiation Factor 5 ELISA kit |
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E04G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Growth Differentiation Factor 5 ELISA kit |
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E04G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Growth Differentiation Factor 5 ELISA kit |
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E04G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rabbit Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Fibroblast growth factor 5 ELISA kit |
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E08F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Canine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Fibroblast growth factor 5 ELISA kit |
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E08F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Canine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Fibroblast growth factor 5 ELISA kit |
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E08F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Canine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Growth Differentiation Factor 5 ELISA kit |
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E08G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Canine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Growth Differentiation Factor 5 ELISA kit |
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E08G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Canine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Growth Differentiation Factor 5 ELISA kit |
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E08G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Canine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Fibroblast growth factor 5 ELISA kit |
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E03F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Fibroblast growth factor 5 ELISA kit |
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E03F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Fibroblast growth factor 5 ELISA kit |
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E03F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Fibroblast growth factor 5 ELISA kit |
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E07F0380-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Fibroblast growth factor 5 ELISA kit |
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E07F0380-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Fibroblast growth factor 5 ELISA kit |
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E07F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Porcine Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Growth Differentiation Factor 5 ELISA kit |
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E07G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Growth Differentiation Factor 5 ELISA kit |
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E07G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Growth Differentiation Factor 5 ELISA kit |
|||
E07G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Porcine Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Growth Differentiation Factor 5 ELISA kit |
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E03G0136-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Growth Differentiation Factor 5 ELISA kit |
|||
E03G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Growth Differentiation Factor 5 ELISA kit |
|||
E03G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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In each mouse fashions, the event of PAH was linked to elevated interleukin-23 manufacturing, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a lack of angiopoietin-2. Collectively, these outcomes assist an essential function for NK cells within the regulation of pulmonary and systemic vascular perform and the pathogenesis of PAH.
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