Physiological Functions of Mcl-1: Insights From Genetic Mouse Models
The flexibility to control the survival and demise of a cell is paramount all through the lifespan of a multicellular organism. Apoptosis, a foremost physiological type of programmed cell demise, is regulated by the Bcl-2 household proteins which are both pro-apoptotic or pro-survival.
The in vivo features of distinct Bcl-2 members of the family are largely unmasked by genetically engineered murine fashions. Mcl-1 is likely one of the two Bcl-2 like pro-survival genes whose germline deletion causes embryonic lethality in mice.
Its requisite for the survival of a broad vary of cell varieties has been additional unraveled by utilizing conditional and inducible deletion murine mannequin programs in numerous tissues or cell lineages and at distinct developmental levels. Furthermore, genetic mouse most cancers fashions have additionally demonstrated that Mcl-1 is crucial for the survival of a number of tumor varieties.
The MCL-1 locus is often amplified throughout numerous most cancers varieties in people. Small molecule inhibitors with excessive affinity and specificity to human MCL-1 have been developed and explored for the therapy of sure cancers. To facilitate the pre-clinical research of MCL-1 in most cancers and different illnesses, transgenic mouse fashions over-expressing human MCL-1 in addition to humanized MCL-1 mouse fashions have been lately engineered.
This overview discusses the present advances in understanding the physiological roles of Mcl-1 based mostly on research utilizing genetic murine fashions and its essential implications in pathology and therapy of human illnesses.
Human B Lymphomas Reveal Their Secrets and techniques By way of Genetic Mouse Fashions
Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and symbolize the sixth most cancers worldwide and probably the most frequent blood most cancers. The vast majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal heart (GC) skilled mature B cells.
GCs are transient buildings that type in lymphoid organs in response to antigen publicity of naive B cells, and the place B cell receptor (BCR) affinity maturation happens to advertise B cell differentiation into reminiscence B and plasma cells producing high-affinity antibodies.
Genomic instability related to the somatic hypermutation (SHM) and class-switch recombination (CSR) processes throughout GC transit improve susceptibility to malignant transformation. Most B cell differentiation steps within the GC are on the origin of frequent B cell malignant entities, specifically Follicular Lymphoma (FL) and GCB diffuse massive B cell lymphomas (GCB-DLBCL).
Over the previous decade, massive sequencing efforts have offered an important enhance within the identification of candidate oncogenes and tumor suppressors concerned in FL and DLBCL oncogenesis. Mouse fashions have been instrumental to precisely mimic in vivo lymphoma-specific mutations and interrogate their regular perform within the GC context and their oncogenic perform resulting in lymphoma onset.
The restricted entry of biopsies throughout the initiating steps of the illness, the mobile and (epi)genetic heterogeneity of particular person tumors throughout and inside sufferers linked to perturbed dynamics of GC ecosystems make the event of genetically engineered mouse fashions essential to decipher lymphomagenesis and illness development and ultimately to check the consequences of novel focused therapies.
On this overview, we offer an summary of a few of the essential genetically engineered mouse fashions which have been developed to recapitulate lymphoma-associated (epi)genetic alterations of two frequent GC-derived lymphoma entities: FL and GCB-DLCBL and describe how these mouse fashions have improved our data of the molecular processes supporting GC B cell transformation.
Benefits of patient-derived orthotopic mouse fashions and genetic reporters for growing fluorescence-guided surgical procedure.
Fluorescence-guided surgical procedure can improve the surgeon’s potential to realize a whole oncologic resection. There are a selection of tumor-specific probes being developed with many preclinical mouse fashions to judge their efficacy.
The present overview discusses the completely different preclinical mouse fashions within the setting of probe analysis and highlights some great benefits of patient-derived orthotopic xenografts (PDOX) mouse fashions and genetic reporters to develop fluorescence-guided surgical procedure.
Modifying out 5 Serpina1 paralogs to create a mouse mannequin of genetic emphysema.
Continual obstructive pulmonary illness impacts 10% of the worldwide inhabitants, and the main genetic trigger is α-1 antitrypsin (AAT) deficiency. Because of the complexity of the murine locus, which incorporates as much as six Serpina1 paralogs, no genetic animal mannequin of the illness has been efficiently generated till now. Right here we create a quintuple Serpina1a-e knockout utilizing CRISPR/Cas9-mediated genome enhancing.
The phenotype recapitulates the human illness phenotype, i.e., absence of hepatic and circulating AAT interprets functionally to a decreased capability to inhibit neutrophil elastase. With age, Serpina1 null mice develop emphysema spontaneously, which might be induced in youthful mice by a lipopolysaccharide problem.
This mouse fashions not solely AAT deficiency but in addition emphysema and is a related genetic mannequin and never one based mostly on developmental impairment of alveolarization or elastase administration. We anticipate that this distinctive mannequin shall be extremely related not solely to the preclinical growth of therapeutics for AAT deficiency, but in addition to emphysema and smoking analysis.
Exome sequencing of the TCL1 mouse mannequin for CLL reveals genetic heterogeneity and dynamics throughout illness growth.
The TCL1 mouse mannequin is extensively used to review pathophysiology, clonal evolution, and drug sensitivity or resistance of persistent lymphocytic leukemia (CLL). By performing entire exome sequencing, we current the genetic panorama of major tumors from TCL1 mice and of TCL1 tumors serially transplanted into wild-type recipients to imitate clonal evolution.
We present that just like CLL sufferers, mutations in mice are ceaselessly subclonal and heterogenous amongst completely different major TCL1 mice. We additional describe that this molecular heterogeneity mirrors heterogenous illness traits corresponding to organ infiltration or CLL dependent T cell skewing. Just like human CLL, we additional noticed the prevalence of novel mutations and structural variations throughout clonal evolution and located plasticity within the growth of B cell receptor particular subclones.
Thus, our outcomes uncover that the genetic complexity, pathway dependence and clonal dynamics in mouse CLL are in related settlement to human CLL, and they’re essential to think about in future analysis utilizing the TCL1 mouse for learning CLL.
Spontaneous pulmonary hypertension in geneticmouse fashions of pure killer cell deficiency.
Pure Killer (NK) cells are cytotoxic innate lymphoid cells with a longtime function within the regulation of vascular construction in being pregnant and most cancers. Impaired NK cell perform has been recognized in sufferers with pulmonary arterial hypertension (PAH), a illness of obstructive vascular reworking within the lungs, in addition to in a number of rodent fashions of illness.
Nonetheless, the exact contribution of NK cell impairment to the initiation and development of PAH stays unknown. Right here we report the event of spontaneous pulmonary hypertension in two impartial genetic fashions of NK cell dysfunction, together with Nfil3-/- mice, that are poor in NK cells because of the absence of the NFIL3 transcription issue, and Ncr1-Gfp mice, which lack the NK activating receptor NKp46.
Mouse fashions of NK insufficiency exhibited elevated proper ventricular systolic stress and muscularization of the pulmonary arteries within the absence of elevated left ventricular finish diastolic stress, indicating that the event of pulmonary hypertension was not secondary to left coronary heart dysfunction.
In circumstances of extreme NK cell impairment or loss, a subset of mice didn’t develop pulmonary hypertension and as an alternative exhibited decreased systemic blood stress, demonstrating an extension of vascular abnormalities past the pulmonary circulation into the systemic vasculature.
Mouse Fibroblast growth factor 5 ELISA kit |
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| E03F0380-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Fibroblast growth factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Fibroblast growth factor 5 ELISA kit |
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| E03F0380-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Fibroblast growth factor 5 ELISA Kit |
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Mouse Fibroblast growth factor 5 ELISA Kit |
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Mouse Fibroblast growth factor 5 ELISA Kit |
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Mouse Fibroblast growth factor 5 ELISA Kit |
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Mouse Fibroblast Growth Factor 5 ELISA Kit |
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Mouse Fibroblast Growth Factor 5 ELISA Kit |
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Mouse Fibroblast Growth Factor 5 ELISA Kit |
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Mouse Fibroblast Growth Factor 5 ELISA Kit |
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Mouse Growth/differentiation factor 5 (Gdf5) |
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| 1-CSB-EP009349MO | Cusabio |
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Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MO | Cusabio | 9462 mg | Ask for price |
Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MO-100ug | Cusabio | 100ug | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MO-1mg | Cusabio | 1mg | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MO-20ug | Cusabio | 20ug | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MOa0 | Cusabio | 10333 mg | Ask for price |
Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MOa0-100ug | Cusabio | 100ug | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MOa0-1mg | Cusabio | 1mg | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| CSB-EP008632MOa0-20ug | Cusabio | 20ug | Ask for price |
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Description: 21-264aa |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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| MBS959020-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1125 |
Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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Recombinant Mouse Fibroblast growth factor 5 (Fgf5) |
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ELISA Kit for Mouse Fibroblast growth factor 5 |
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| E0397m | EIAab | 96T | EUR 387.4 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| AE43665MO-48T | Abebio | 48T | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| AE43665MO-48Tests | Abebio | 48 Tests | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| AE43665MO-96T | Abebio | 96T | EUR 610 |
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Description: Mouse (Mus musculus) |
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Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| AE43665MO-96Tests | Abebio | 96 Tests | EUR 610 |
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Description: Mouse (Mus musculus) |
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Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| CSB-EL008632MO-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5 (FGF5) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| CSB-EL008632MO-48T | Cusabio | 48T | EUR 338.81 |
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Description: Mus musculus (Mouse) |
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Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| 1-CSB-EL008632MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5(FGF5) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| CSB-EL008632MO-96T | Cusabio | 96T | EUR 521.25 |
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Description: Mus musculus (Mouse) |
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Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKU11122-48T | Biomatik Corporation | 48T | EUR 617.68 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKU11122-5x96T | Biomatik Corporation | 5x96T | EUR 4191.4 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKU11122-96T | Biomatik Corporation | 96T | EUR 882.4 |
Mouse Fibroblast growth factor 5,FGF5 ELISA KIT |
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| JOT-EK2072Mo | Jotbody | 96 wells | Ask for price |
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Description: Mouse |
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Mouse Fibroblast growth factor 5,FGF5 ELISA KIT |
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| E2072Mo-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Mouse Fibroblast growth factor 5,FGF5 ELISA KIT |
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| E2072Mo-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Mouse Fibroblast growth factor 5,FGF5 ELISA KIT |
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| E2072Mo-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Mouse Fibroblast growth factor 5,FGF5 ELISA KIT |
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| E2072Mo-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| EKC36871-48T | Biomatik Corporation | 48T | EUR 535.99 |
Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| EKC36871-5x96T | Biomatik Corporation | 5x96T | EUR 3637.08 |
Mouse Fibroblast growth factor 5(FGF5) ELISA kit |
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| EKC36871-96T | Biomatik Corporation | 96T | EUR 765.7 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKN52233-48T | Biomatik Corporation | 48T | EUR 384.3 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKN52233-5x96T | Biomatik Corporation | 5x96T | EUR 2607.75 |
Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit |
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| EKN52233-96T | Biomatik Corporation | 96T | EUR 549 |
Mouse Fibroblast growth factor 5(FGF5) Elisa kit |
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| EK730847 | AFG Bioscience LLC | 96 Wells | EUR 0.72 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS1604966-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3955 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS1604966-48StripWells | MyBiosource | 48-Strip-Wells | EUR 305 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS1604966-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2005 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS1604966-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| MBS2803671-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6255 |
Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| MBS2803671-48StripWells | MyBiosource | 48-Strip-Wells | EUR 445 |
Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| MBS2803671-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3290 |
Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| MBS2803671-96StripWells | MyBiosource | 96-Strip-Wells | EUR 730 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS931255-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5575 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS931255-24StripWellsLIMIT1 | MyBiosource | 24-Strip-Wells(LIMIT1) | EUR 275 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS931255-48StripWells | MyBiosource | 48-Strip-Wells | EUR 545 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS931255-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2920 |
Mouse Fibroblast growth factor 5, FGF5 ELISA Kit |
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| MBS931255-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit |
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| RK06732 | Abclonal | 96T | EUR 322.37 |
Fibroblast growth factor 5 |
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| AP89391 | SAB | 1mg | EUR 2640 |
Fibroblast growth factor 5 |
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| AP82670 | SAB | 1mg | EUR 2640 |
Fibroblast growth factor 5 |
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| AP82956 | SAB | 1mg | EUR 2640 |
Fibroblast growth factor 5 |
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| AP83077 | SAB | 1mg | EUR 2640 |
Fibroblast growth factor 5 |
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| AP83491 | SAB | 1mg | EUR 2640 |
Recombinant Mouse Growth/differentiation factor 5 |
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| MBS718033-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 320 |
Recombinant Mouse Growth/differentiation factor 5 |
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| MBS718033-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 520 |
Recombinant Mouse Growth/differentiation factor 5 |
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| MBS718033-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1925 |
Recombinant Mouse Growth/differentiation factor 5 |
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| MBS718033-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | EUR 8405 |
Recombinant mouse Growth/differentiation factor 5 |
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| MBS9420263-002mg | MyBiosource | 0.02mg | EUR 380 |
Recombinant mouse Growth/differentiation factor 5 |
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| MBS9420263-01mg | MyBiosource | 0.1mg | EUR 650 |
Recombinant mouse Growth/differentiation factor 5 |
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| MBS9420263-1mg | MyBiosource | 1mg | EUR 2525 |
Recombinant mouse Growth/differentiation factor 5 |
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| MBS9420263-5x1mg | MyBiosource | 5x1mg | EUR 11205 |
Mouse Fibroblast Growth Factor 5, FGF5 GENLISA ELISA |
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| KLM2072 | Krishgen | 1 x 96 wells | EUR 341 |
Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit |
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| E01A21934 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit |
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| E03F0069-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit |
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| E03F0069-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Growth Differentiation Factor 5 CLIA Kit |
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| MBS8426250-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Growth Differentiation Factor 5 ELISA kit |
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| E01A22208 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS020589-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS020589-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS020589-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS020589-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Growth Differentiation Factor 5 ELISA kit |
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| E03G0136-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Growth Differentiation Factor 5 ELISA kit |
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| E03G0136-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Growth Differentiation Factor 5 ELISA kit |
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| E03G0136-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Growth Differentiation Factor 5 ELISA kit |
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| E03G0136-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Growth Differentiation Factor 5 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Growth Differentiation Factor 5 ELISA kit |
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| E03G0136-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| IMSGDF5KT | Innovative research | each | EUR 890 |
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Description: Mouse Growth Differentiation Factor 5 ELISA Kit |
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Mouse Growth/differentiation factor 5 ELISA Kit |
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| MBS2885176-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4080 |
Mouse Growth/differentiation factor 5 ELISA Kit |
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| MBS2885176-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
Mouse Growth/differentiation factor 5 ELISA Kit |
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| MBS2885176-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2220 |
Mouse Growth/differentiation factor 5 ELISA Kit |
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| MBS2885176-96StripWells | MyBiosource | 96-Strip-Wells | EUR 520 |
Mouse Growth/differentiation Factor 5 ELISA Kit |
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| MBS760474-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Mouse Growth/differentiation Factor 5 ELISA Kit |
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| MBS760474-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Mouse Growth/differentiation Factor 5 ELISA Kit |
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| MBS760474-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Mouse Growth/differentiation Factor 5 ELISA Kit |
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| MBS760474-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS728393-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS728393-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS728393-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS728393-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS8420609-1Kit | MyBiosource | 1Kit | EUR 755 |
Mouse Growth Differentiation Factor 5 ELISA Kit |
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| MBS8420609-5x1Kit | MyBiosource | 5x1Kit | EUR 3455 |
Mouse Growth Differentiation Factor 5 (GDF5) Protein |
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| abx066946-100g | Abbexa | 100 µg | EUR 475 |
Mouse Growth Differentiation Factor 5 (GDF5) Protein |
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| 20-abx066946 | Abbexa |
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Mouse Growth Differentiation Factor 5 (GDF5) Protein |
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| abx066946-10g | Abbexa | 10 µg | EUR 200 |
Mouse Growth Differentiation Factor 5 (GDF5) Protein |
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| abx066946-50g | Abbexa | 50 µg | EUR 337.5 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE) |
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| MBS6157803-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE) |
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| MBS6157803-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP) |
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| MBS6131288-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP) |
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| MBS6131288-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP) |
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| MBS6378515-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (AP) |
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| MBS6378515-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE) |
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| MBS6378525-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (PE) |
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| MBS6378525-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC) |
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| MBS6147197-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC) |
|||
| MBS6147197-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP) |
|||
| MBS6152500-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP) |
|||
| MBS6152500-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC |
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| MBS6136591-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC |
|||
| MBS6136591-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC |
|||
| MBS6378516-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) APC |
|||
| MBS6378516-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC) |
|||
| MBS6378518-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (FITC) |
|||
| MBS6378518-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP) |
|||
| MBS6378519-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (HRP) |
|||
| MBS6378519-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin) |
|||
| MBS6141894-01mL | MyBiosource | 0.1(mL | EUR 875 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin) |
|||
| MBS6141894-5x01mL | MyBiosource | 5x0.1mL | EUR 3800 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin) |
|||
| MBS6378517-01mL | MyBiosource | 0.1mL | EUR 920 |
FGF5 (Fibroblast Growth Factor 5, FGF-5, Heparin-binding Growth Factor 5, HBGF-5, Smag-82) (Biotin) |
|||
| MBS6378517-5x01mL | MyBiosource | 5x0.1mL | EUR 3990 |
Fgf5 (untagged ORF) - Rat fibroblast growth factor 5 (Fgf5), (10 ug) |
|||
| RN215452 | Origene Technologies GmbH | 10 µg | Ask for price |
Fgf5 (GFP-tagged) - Mouse fibroblast growth factor 5 (Fgf5) |
|||
| MG203484 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Mouse Growth and Differentiation factor 5 |
|||
| cyt-941-10g | ProSpec Tany | 10µg | EUR 60 |
Recombinant Mouse Growth and Differentiation factor 5 |
|||
| cyt-941-1mg | ProSpec Tany | 1mg | EUR 1350 |
Recombinant Mouse Growth and Differentiation factor 5 |
|||
| cyt-941-50g | ProSpec Tany | 50µg | EUR 145 |
Recombinant Mouse Growth and Differentiation factor 5 |
|||
| MBS141101-001mg | MyBiosource | 0.01mg | EUR 240 |
In each mouse fashions, the event of PAH was linked to elevated interleukin-23 manufacturing, whereas systemic hypotension in Ncr1-Gfp mice was accompanied by a lack of angiopoietin-2. Collectively, these outcomes assist an essential function for NK cells within the regulation of pulmonary and systemic vascular perform and the pathogenesis of PAH.
