
Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models
Danielle
- 0
Declined high quality and amount of sperm is presently the main reason for sufferers affected by infertility. Male germ cell growth is spatiotemporally regulated all through the entire developmental course of. Whereas it has been identified that exogenous components, similar to environmental publicity, eating regimen and life-style, et al, play causative roles in male infertility, current progress has revealed ample genetic mutations tightly related to faulty male germline growth.
In mammals, male germ cells bear dramatic morphological change (i.e., nuclear condensation) and chromatin transforming throughout post-meiotic haploid germline growth, a course of termed spermiogenesis; Nevertheless, the molecular equipment gamers and practical mechanisms have but to be recognized.
Thus far, gathered proof means that disruption in any step of haploid germline growth is probably going manifested as fertility points with low sperm rely, poor sperm motility, aberrant sperm morphology or mixed. With the regularly declined value of next-generation sequencing and up to date progress of CRISPR/Cas9 know-how, rising research have revealed an enormous variety of disease-causing genetic variants related to spermiogenic defects in each mice and people, together with mechanistic insights partially attained and validated by genetically engineered mouse fashions (GEMMs).
On this assessment, we primarily summarize genes which can be practical at post-meiotic stage. Identification and characterization of deleterious genetic variants ought to assist in our understanding of germline growth, and thereby additional enhance the analysis and therapy of male infertility.
Genetic Depletion of Amylin/Calcitonin Receptors Improves Reminiscence and Studying in Transgenic Alzheimer’s Illness Mouse Fashions
Primarily based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a category B G protein-coupled receptor (GPCR), is a possible modulator of Alzheimer’s illness (AD) pathogenesis. Nevertheless, previous pharmacological approaches have didn’t resolve whether or not activation or blockade of this receptor would have better therapeutic profit.
To handle this situation, we generated compound mice expressing a human amyloid precursor protein gene with familial AD mutations together with deficiency of amylin receptors produced by hemizygosity for the essential calcitonin receptor subunit of this heterodimeric GPCR. These compound transgenic AD mice demonstrated attenuated responses to human amylin- and Aβ-induced melancholy of hippocampal long-term potentiation (LTP) consistent with the genetic depletion of amylin receptors.
Each the LTP responses and spatial reminiscence (as measured with Morris water maze) in these mice have been improved in comparison with AD mouse controls and, importantly, a discount in each the amyloid plaque burden and markers of neuroinflammation was noticed. Our information assist the notion of additional growth of antagonists of the amylin receptor as AD-modifying therapies.
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like illness
The transcription issue IRF5 has been implicated as a therapeutic goal for the autoimmune illness systemic lupus erythematosus (SLE). Nevertheless, IRF5 activation standing through the illness course and the results of IRF5 inhibition after illness onset are unclear.
Right here, we present that SLE sufferers in each the energetic and remission part have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of kind I interferon signaling in suppressing illness in a mouse mannequin of SLE, probably because of the operate of IRF5 in oxidative phosphorylation.
We additional show that inhibition of IRF5 by way of conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after illness onset suppresses illness development and is efficient for upkeep of remission in mice. These outcomes recommend that IRF5 inhibition would possibly overcome the constraints of present SLE therapies, thus selling drug discovery analysis on IRF5 inhibitors.
The developmental and genetic foundation of ‘clubfoot’ within the peroneal muscular atrophy mutant mouse.
Genetic components underlying the human limb abnormality congenital talipes equinovarus (‘clubfoot’) stay incompletely understood. The spontaneous autosomal recessive mouse ‘peroneal muscular atrophy’ mutant (PMA) is a trustworthy morphological mannequin of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent.
On this examine, the first developmental defect was recognized as a lowered progress of sciatic nerve lateral motor column (LMC) neurons resulting in failure to challenge to dorsal (peroneal) decrease limb muscle blocks. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) recognized, which is upregulated in mutant lateral LMC motor neurons.
Genetic and molecular analyses confirmed that the mutation acts within the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate progress cone extension/collapse. Within the hen, each experimental upregulation of Limk1 by electroporation and pharmacological inhibition of actin turnover led to defects in hindlimb spinal motor neuron progress and pathfinding, and mimicked the clubfoot phenotype. The info assist a neuromuscular aetiology for clubfoot and supply a mechanistic framework to grasp clubfoot in people.

Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal group.
Macrophages are innate immune cells that continually patrol an organism to meet protecting and homeostatic roles. Earlier research have proven that Rho GTPase exercise is required for macrophage mobility, but the roles of upstream regulatory proteins controlling Rho GTPase operate in these cells will not be effectively outlined.
Beforehand we’ve got proven that the RhoA GEF Net1 is required for human breast most cancers cell motility and extracellular matrix invasion. To evaluate the function of Net1 in macrophage motility, we remoted bone marrow macrophage (BMM) precursors from wild kind and Net1 knockout mice.
Lack of Net1 didn’t have an effect on the power of BMM precursors to distinguish into mature macrophages in vitro, as measured by CD68 and F4/80 staining. Nevertheless, Net1 deletion considerably lowered RhoA activation, F-actin accumulation, adhesion, and motility in these cells.
Nonetheless, just like RhoA/RhoB double knockout macrophages, Net1 deletion didn’t impair macrophage recruitment to the peritoneum in a mouse mannequin of sterile irritation. These information show that Net1 is a vital regulator of RhoA signaling and motility in mouse macrophages in vitro, however that its operate could also be dispensable for macrophage recruitment to inflammatory websites in vivo.
In Niemann-Decide C1 mouse fashions, glial-only expression of the traditional gene extends survival a lot additional than do modifications in genetic background or therapy with hydroxypropyl-beta-cyclodextrin.
The Npc1nmf164 allele of Npc1 gives a mouse mannequin for Niemann-Decide illness kind C1 (NPC1), a genetic illness identified to have a extensively variable phenotype.
The switch of the Npc1nmf164 mutation from the C57BL/6J inbred pressure to the BALB/cJ inbred pressure elevated the imply lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background.
The switch of one other Npc1 allele, Npc1nih, to this background additionally prolonged survival of the homozygotes indicating that the modifying impact of BALB/cJ isn’t restricted to a single allele of Npc1. The elevated longevity because of the BALB/cJ background didn’t map to a beforehand mapped modifier on chromosome 19, indicating the presence of extra genes impacting illness severity.
The beforehand studied Glial Fibrillary Acidic Protein promoter-Npc1 cDNA transgene (GFAP-Npc1) which solely expresses NPC1 in astrocytes additional prolonged the lifespan of Npc1nmf164 homozygotes on a BALB/cJ background (as much as 600days). Hydroxypropyl-β-cyclodextrin (HPβCD) therapy, not beforehand examined within the Npc1nmf164 mutant, prolonged life within the Npc1nmf164 homozygotes however not the transgenic, Npc1nmf164 mice on the BALB/cJ background.
Mouse Podoplanin (PDPN) ELISA Kit |
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20-abx154564 | Abbexa |
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Mouse Podoplanin (PDPN) ELISA Kit |
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abx571749-96tests | Abbexa | 96 tests | EUR 943.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-96T | DL Develop | 96T | EUR 825.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin, Pdpn ELISA KIT |
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ELI-06723m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5834.88 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 585.7 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 785.28 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3173.76 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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4-SEC719Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 888 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RDR-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RDR-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 928.8 |
Mouse Podoplanin(PDPN)ELISA kit |
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QY-E21215 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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DL-PDPN-Mu | DL Develop | 96T | EUR 453 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu | DL Develop | 96T | EUR 475 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RDR-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 487.52 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RDR-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 696.47 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 464.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 663.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN)ELISA kit |
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YLA0596MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse Podoplanin (PDPN)ELISA kit |
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YLA0596MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
Podoplanin |
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MO47016 | Neuromics | 100 ul | EUR 418.8 |
Podoplanin |
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E8ET1703-61 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
Podoplanin |
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E8ER1915-23 | EnoGene | 100ul | EUR 275 |
Description: Available in various conjugation types. |
Recombinant Mouse Podoplanin (C-Fc) |
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CU73-1mg | Novoprotein | 1mg | EUR 2008.8 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
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CU73-500ug | Novoprotein | 500ug | EUR 1399.2 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
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CU73-50ug | Novoprotein | 50ug | EUR 327.6 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
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CU73-10ug | Novoprotein | 10ug | EUR 157.2 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
ELISA kit for Mouse Podoplanin (PDPN) |
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KTE70775-48T | Abbkine | 48T | EUR 398.4 |
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Podoplanin (PDPN) |
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KTE70775-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Podoplanin (PDPN) |
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KTE70775-96T | Abbkine | 96T | EUR 646.8 |
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse) |
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4-PAC719Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN) |
Podoplanin antibody |
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10R-7662 | Fitzgerald | 100 ug | EUR 754.8 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
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10R-7663 | Fitzgerald | 100 ug | EUR 754.8 |
Description: Hamster monoclonal Podoplanin antibody |
Podoplanin antibody |
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10R-7664 | Fitzgerald | 100 ug | EUR 754.8 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
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10R-P133a | Fitzgerald | 100 ug | EUR 608.4 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
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10R-P155a | Fitzgerald | 100 ug | EUR 651.6 |
Description: Hamster monoclonal Podoplanin antibody |
Podoplanin antibody |
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70R-PR007 | Fitzgerald | 100 ug | EUR 506.4 |
Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
Podoplanin antibody |
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70R-11540 | Fitzgerald | 100 ug | EUR 632.4 |
Description: Rabbit polyclonal Podoplanin antibody |
Podoplanin Antibody |
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49474-100ul | SAB | 100ul | EUR 399.6 |
Podoplanin Antibody |
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49474-50ul | SAB | 50ul | EUR 286.8 |
Podoplanin antibody |
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70R-13952 | Fitzgerald | 100 ug | EUR 366 |
Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
Podoplanin antibody |
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70R-6816 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN |
Podoplanin antibody |
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70R-6817 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN |
Podoplanin antibody |
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70R-50819 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal Podoplanin antibody |
Podoplanin Antibody |
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P1051-01m | SAB | 0.1m | EUR 250.8 |
Podoplanin Antibody |
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P1051-1ml | SAB | 1ml | EUR 1129.2 |
Podoplanin Antibody |
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R33852-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: PDPN; AGGRUS; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26 |
Podoplanin Antibody |
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R20464-0.1ML | NSJ Bioreagents | 100ul | EUR 409 |
Podoplanin Antibody |
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E38PA2500 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Podoplanin Antibody |
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DF12456-100ul | Affinity Biosciences | 100ul | EUR 280 |
Podoplanin Antibody |
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DF12456-200ul | Affinity Biosciences | 200ul | EUR 350 |
Podoplanin Antibody |
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DF12456 | Affinity Biosciences | 100ul | EUR 280 |
Description: Human,Mouse |
ELISA kit for Mouse PDPN (Podoplanin) |
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E-EL-M2409 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Mouse PDPN (Podoplanin) |
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ELK7080 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE |
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4-PAC719Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE. |
Anti-D2-40/Podoplanin antibody |
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STJ190048 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1) |
Anti-D2-40 Podoplanin antibody |
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STJ16100360 | St John's Laboratory | 1 mL | EUR 1482 |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC |
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4-PAC719Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), Cy3 |
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4-PAC719Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Cy3. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), HRP |
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4-PAC719Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with HRP. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), FITC |
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4-PAC719Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with FITC. |
Podoplanin (PDPN) Antibody |
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20-abx137407 | Abbexa |
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Podoplanin (PDPN) Antibody |
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abx236598-100ug | Abbexa | 100 ug | EUR 661.2 |
Podoplanin (PDPN) Antibody |
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abx236599-100ug | Abbexa | 100 ug | EUR 661.2 |
Podoplanin (PDPN) Antibody |
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20-abx174125 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx174126 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx178065 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx178066 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx178067 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx211099 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx114559 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx129101 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx131102 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx123399 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx339428 | Abbexa |
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Podoplanin (PDPN) Antibody |
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abx433110-200ul | Abbexa | 200 ul | EUR 460.8 |
Podoplanin (PDPN) Antibody |
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20-abx005408 | Abbexa |
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Podoplanin (PDPN) Antibody |
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20-abx008317 | Abbexa |
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Podoplanin Antibody gp36 |
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R30481 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Podoplanin is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the gene to chromosome 1. It is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury. |
Podoplanin Antibody / gp36 |
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R30760 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: PDPN (Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells. |
Podoplanin Antibody / gp36 |
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V3404-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Podoplanin Antibody / gp36 |
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V3404-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Podoplanin Antibody / gp36 |
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V3404SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Pdpn Antibody /Podoplanin |
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RQ6390 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Podoplanin (PDPN) is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the T1A gene to chromosome 1. It has got 162 amino acid protein which is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. Northern blot analysis detected a 1.2-kb T1A2 transcript only in lung. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury. |
Podoplanin Antibody / gp36 |
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V8695-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Podoplanin Antibody / gp36 |
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V8695-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Podoplanin Antibody / gp36 |
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V8695SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761 |
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CABT-L2919-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
Podoplanin Rabbit pAb |
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E2381729 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Podoplanin Rabbit pAb |
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E2381779 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Podoplanin rabbit pAb |
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E28PT7965 | EnoGene | 100μl | EUR 255 |
Description: Available in various conjugation types. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC-Cy7 |
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4-PAC719Mu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC-Cy7. |
Podoplanin (PDPN) Antibody (Cy3) |
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20-abx274445 | Abbexa |
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Podoplanin Antibody (IHC Gold) |
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E36PA650 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Podoplanin (PDPN) Protein |
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20-abx262003 | Abbexa |
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Podoplanin Conjugated Antibody |
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C49474 | SAB | 100ul | EUR 476.4 |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), Biotinylated |
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4-PAC719Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Biotin. |
Dog Podoplanin ELISA kit |
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E08P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Podoplanin ELISA kit |
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E08P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Podoplanin ELISA kit |
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E08P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Podoplanin ELISA kit |
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E02P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Podoplanin ELISA kit |
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E02P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Podoplanin ELISA kit |
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E02P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Podoplanin ELISA kit |
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E07P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Podoplanin ELISA kit |
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E07P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Podoplanin ELISA kit |
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E07P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Podoplanin ELISA Kit |
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IRTPDPNKT | Innovative research | each | EUR 790 |
Description: Rat Podoplanin ELISA Kit |
Goat Podoplanin ELISA kit |
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E06P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Podoplanin ELISA kit |
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E06P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Podoplanin ELISA kit |
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E06P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Podoplanin Blocking Peptide |
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20-abx063694 | Abbexa |
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Podoplanin Blocking Peptide |
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33R-2420 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816 |
Podoplanin Blocking Peptide |
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33R-9441 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817 |
Podoplanin Blocking Peptide |
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DF12456-BP | Affbiotech | 1mg | EUR 234 |
Recombinant Podoplanin (PDPN) |
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4-RPC719Hu01 | Cloud-Clone |
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Description: Recombinant Human Podoplanin expressed in: E.coli |
Recombinant Podoplanin (PDPN) |
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4-RPC719Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Podoplanin expressed in: E.coli |
Human Podoplanin ELISA kit |
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E01P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Podoplanin ELISA kit |
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E01P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Podoplanin ELISA kit |
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E01P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Podoplanin ELISA Kit |
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IHUPDPNKT | Innovative research | each | EUR 733 |
Description: Human Podoplanin ELISA Kit |
Podoplanin / GP36 / T1A-2 Antibody |
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abx031419-400ul | Abbexa | 400 ul | EUR 627.6 |
Podoplanin / GP36 / T1A-2 Antibody |
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abx031419-80l | Abbexa | 80 µl | EUR 343.2 |
Recombinant Human Podoplanin |
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7-05839 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Podoplanin |
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7-05840 | CHI Scientific | 25µg | Ask for price |
Recombinant Human Podoplanin |
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7-05841 | CHI Scientific | 1mg | Ask for price |
Rat Podoplanin (PDPN) Protein |
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20-abx654779 | Abbexa |
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Cow Podoplanin (PDPN) Protein |
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20-abx654780 | Abbexa |
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Rabbit Podoplanin ELISA kit |
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E04P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Podoplanin ELISA kit |
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E04P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Podoplanin ELISA kit |
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E04P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Podoplanin ELISA kit |
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E09P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Podoplanin ELISA kit |
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E09P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Podoplanin ELISA kit |
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E09P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Podoplanin Recombinant Protein |
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91-478 | ProSci | 0.05 mg | EUR 537.9 |
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels. |
Podoplanin Recombinant Protein |
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91-788 | ProSci | 0.05 mg | EUR 588.3 |
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels. |
Rat Podoplanin (PDPN) CLIA Kit |
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20-abx493859 | Abbexa |
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Human Podoplanin (PDPN) Protein |
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20-abx166428 | Abbexa |
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Rat Podoplanin (PDPN) ELISA Kit |
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abx255914-96tests | Abbexa | 96 tests | EUR 848.4 |
Rat Podoplanin (PDPN) ELISA Kit |
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20-abx155993 | Abbexa |
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Rat Podoplanin (PDPN) ELISA Kit |
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abx570903-96tests | Abbexa | 96 tests | EUR 848.4 |
Pig Podoplanin (PDPN) ELISA Kit |
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abx360730-96tests | Abbexa | 96 tests | EUR 990 |
Dog Podoplanin (PDPN) ELISA Kit |
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abx519384-96tests | Abbexa | 96 tests | EUR 1093.2 |
Rat Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Ra-48T | DL Develop | 48T | EUR 658.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Ra-96T | DL Develop | 96T | EUR 861.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat PDPN(Podoplanin) ELISA Kit |
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ER1249 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
Rat Podoplanin, Pdpn ELISA KIT |
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ELI-06726r | Lifescience Market | 96 Tests | EUR 1063.2 |
Rat Podoplanin (PDPN) ELISA Kit |
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SEC719Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6149.04 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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In all circumstances, lack of weight acquire and early cerebellar signs of lack of motor management have been discovered. At termination, the one mouse sacrificed for histological research confirmed extreme, diffuse pulmonary alveolar proteinosis suggesting that pulmonary abnormalities in NPC1 mouse fashions will not be distinctive to the Npc1nih allele.
Tags: bl21 de3 star e2 crimson egfp c1 egfp n1 jm110 lenticrispr mcherry plasmid p3xflag cmv 10 paav-mcs pacyc184 pbi121 pbluescript sequence pcdh vector pcdna3 ha pcdna5 frt pcep4 pci neo pci vector pcmv flag pcmv vsv g pcr blunt pcr2 1 sequence pcr2 1 topo vector pcr2 1 vector pcrii pdest pdonr201 pegfp c1 vector pegfp c3 pegfp plasmid pentr dtopo pet 15b pet15b sequence pet19b pet21a vector pet24 pet28 pet28a sequence pet28c pet32a pet41a petduet vector petduet-1 peyfp pgbkt7 pgex 6p 2 pgex plasmid pgex vector pgl3 sequence pgl3-promoter plenti6 plko 1 vector plko puro plko tet on plvx tight puro pmcherry pmscv puro prep4 prset a prset b prset vector pspax2 ptripz puc18 map puc18 sequence puc19 plasmid yfp