Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Declined high quality and amount of sperm is presently the main reason for sufferers affected by infertility. Male germ cell growth is spatiotemporally regulated all through the entire developmental course of. Whereas it has been identified that exogenous components, similar to environmental publicity, eating regimen and life-style, et al, play causative roles in male infertility, current progress has revealed ample genetic mutations tightly related to faulty male germline growth.
In mammals, male germ cells bear dramatic morphological change (i.e., nuclear condensation) and chromatin transforming throughout post-meiotic haploid germline growth, a course of termed spermiogenesis; Nevertheless, the molecular equipment gamers and practical mechanisms have but to be recognized.
Thus far, gathered proof means that disruption in any step of haploid germline growth is probably going manifested as fertility points with low sperm rely, poor sperm motility, aberrant sperm morphology or mixed. With the regularly declined value of next-generation sequencing and up to date progress of CRISPR/Cas9 know-how, rising research have revealed an enormous variety of disease-causing genetic variants related to spermiogenic defects in each mice and people, together with mechanistic insights partially attained and validated by genetically engineered mouse fashions (GEMMs).
On this assessment, we primarily summarize genes which can be practical at post-meiotic stage. Identification and characterization of deleterious genetic variants ought to assist in our understanding of germline growth, and thereby additional enhance the analysis and therapy of male infertility.

Genetic Depletion of Amylin/Calcitonin Receptors Improves Reminiscence and Studying in Transgenic Alzheimer’s Illness Mouse Fashions

Primarily based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a category B G protein-coupled receptor (GPCR), is a possible modulator of Alzheimer’s illness (AD) pathogenesis. Nevertheless, previous pharmacological approaches have didn’t resolve whether or not activation or blockade of this receptor would have better therapeutic profit.
To handle this situation, we generated compound mice expressing a human amyloid precursor protein gene with familial AD mutations together with deficiency of amylin receptors produced by hemizygosity for the essential calcitonin receptor subunit of this heterodimeric GPCR. These compound transgenic AD mice demonstrated attenuated responses to human amylin- and Aβ-induced melancholy of hippocampal long-term potentiation (LTP) consistent with the genetic depletion of amylin receptors.
Each the LTP responses and spatial reminiscence (as measured with Morris water maze) in these mice have been improved in comparison with AD mouse controls and, importantly, a discount in each the amyloid plaque burden and markers of neuroinflammation was noticed. Our information assist the notion of additional growth of antagonists of the amylin receptor as AD-modifying therapies.

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like illness

The transcription issue IRF5 has been implicated as a therapeutic goal for the autoimmune illness systemic lupus erythematosus (SLE). Nevertheless, IRF5 activation standing through the illness course and the results of IRF5 inhibition after illness onset are unclear.
Right here, we present that SLE sufferers in each the energetic and remission part have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of kind I interferon signaling in suppressing illness in a mouse mannequin of SLE, probably because of the operate of IRF5 in oxidative phosphorylation.
We additional show that inhibition of IRF5 by way of conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after illness onset suppresses illness development and is efficient for upkeep of remission in mice. These outcomes recommend that IRF5 inhibition would possibly overcome the constraints of present SLE therapies, thus selling drug discovery analysis on IRF5 inhibitors.

The developmental and genetic foundation of ‘clubfoot’ within the peroneal muscular atrophy mutant mouse.

Genetic components underlying the human limb abnormality congenital talipes equinovarus (‘clubfoot’) stay incompletely understood. The spontaneous autosomal recessive mouse ‘peroneal muscular atrophy’ mutant (PMA) is a trustworthy morphological mannequin of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent.
On this examine, the first developmental defect was recognized as a lowered progress of sciatic nerve lateral motor column (LMC) neurons resulting in failure to challenge to dorsal (peroneal) decrease limb muscle blocks. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) recognized, which is upregulated in mutant lateral LMC motor neurons.
Genetic and molecular analyses confirmed that the mutation acts within the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate progress cone extension/collapse. Within the hen, each experimental upregulation of Limk1 by electroporation and pharmacological inhibition of actin turnover led to defects in hindlimb spinal motor neuron progress and pathfinding, and mimicked the clubfoot phenotype. The info assist a neuromuscular aetiology for clubfoot and supply a mechanistic framework to grasp clubfoot in people.
Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal group.

Macrophages are innate immune cells that continually patrol an organism to meet protecting and homeostatic roles. Earlier research have proven that Rho GTPase exercise is required for macrophage mobility, but the roles of upstream regulatory proteins controlling Rho GTPase operate in these cells will not be effectively outlined.
Beforehand we’ve got proven that the RhoA GEF Net1 is required for human breast most cancers cell motility and extracellular matrix invasion. To evaluate the function of Net1 in macrophage motility, we remoted bone marrow macrophage (BMM) precursors from wild kind and Net1 knockout mice.
Lack of Net1 didn’t have an effect on the power of BMM precursors to distinguish into mature macrophages in vitro, as measured by CD68 and F4/80 staining. Nevertheless, Net1 deletion considerably lowered RhoA activation, F-actin accumulation, adhesion, and motility in these cells.
Nonetheless, just like RhoA/RhoB double knockout macrophages, Net1 deletion didn’t impair macrophage recruitment to the peritoneum in a mouse mannequin of sterile irritation. These information show that Net1 is a vital regulator of RhoA signaling and motility in mouse macrophages in vitro, however that its operate could also be dispensable for macrophage recruitment to inflammatory websites in vivo.

In Niemann-Decide C1 mouse fashions, glial-only expression of the traditional gene extends survival a lot additional than do modifications in genetic background or therapy with hydroxypropyl-beta-cyclodextrin.

The Npc1nmf164 allele of Npc1 gives a mouse mannequin for Niemann-Decide illness kind C1 (NPC1), a genetic illness identified to have a extensively variable phenotype.
The switch of the Npc1nmf164 mutation from the C57BL/6J inbred pressure to the BALB/cJ inbred pressure elevated the imply lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background.
The switch of one other Npc1 allele, Npc1nih, to this background additionally prolonged survival of the homozygotes indicating that the modifying impact of BALB/cJ isn’t restricted to a single allele of Npc1. The elevated longevity because of the BALB/cJ background didn’t map to a beforehand mapped modifier on chromosome 19, indicating the presence of extra genes impacting illness severity.
The beforehand studied Glial Fibrillary Acidic Protein promoter-Npc1 cDNA transgene (GFAP-Npc1) which solely expresses NPC1 in astrocytes additional prolonged the lifespan of Npc1nmf164 homozygotes on a BALB/cJ background (as much as 600days). Hydroxypropyl-β-cyclodextrin (HPβCD) therapy, not beforehand examined within the Npc1nmf164 mutant, prolonged life within the Npc1nmf164 homozygotes however not the transgenic, Npc1nmf164 mice on the BALB/cJ background.

Podoplanin

MO47016 100 ul
EUR 349

Anti-Podoplanin Rabbit Monoclonal Antibody

M01124-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Podoplanin Rabbit Monoclonal Antibody

M01124-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human.

Anti-Podoplanin/gp36/PDPN Antibody

PA1411 100ug/vial
EUR 294

Anti-Podoplanin/gp36/PDPN Antibody

PA1674 100ug/vial
EUR 294

Anti-Podoplanin/gp36/PDPN Antibody

PA1675 100ug/vial
EUR 294

Anti-D2-40 Podoplanin antibody

STJ16100360 1 mL
EUR 1235

Anti-D2-40/Podoplanin antibody

STJ190048 200 µl
EUR 197
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1)

Anti-Podoplanin/gp36/PDPN Antibody

A01124 100ug/vial
EUR 294

Mouse Podoplanin (PDPN) Protein

20-abx650139
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Podoplanin ELISA kit

E03P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761

CABT-L2919-100uL500uL 100 uL, 500 uL
EUR 502

Podoplanin Antibody

49474-100ul 100ul
EUR 333

Podoplanin Antibody

49474-50ul 50ul
EUR 239

Podoplanin Antibody

P1051-01m 0.1m
EUR 209

Podoplanin Antibody

P1051-1ml 1ml
EUR 941

Podoplanin Antibody

DF12456 200ul
EUR 304
Description: Podoplanin antibody detects endogenous levels of Podoplanin.

Podoplanin antibody

10R-7662 100 ug
EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody

10R-7663 100 ug
EUR 629
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody

10R-7664 100 ug
EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody

10R-P133a 100 ug
EUR 507
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody

10R-P155a 100 ug
EUR 543
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody

70R-11540 100 ug
EUR 527
Description: Rabbit polyclonal Podoplanin antibody

Podoplanin antibody

70R-13952 100 ug
EUR 305
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody

70R-6816 50 ug
EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN

Podoplanin antibody

70R-6817 50 ug
EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN

Podoplanin antibody

70R-50819 100 ul
EUR 244
Description: Purified Polyclonal Podoplanin antibody

Podoplanin antibody

70R-PR007 100 ug
EUR 422
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Podoplanin (PDPN) Polyclonal Antibody (Mouse)

4-PAC719Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN)

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

4-SEC719Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-48Tests 48 Tests
EUR 533

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-96Tests 96 Tests
EUR 740

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

abx571749-96tests 96 tests
EUR 786

Mouse Podoplanin (PDPN) CLIA Kit

20-abx493858
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

20-abx154564
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-48Tests 48 Tests
EUR 557

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-96Tests 96 Tests
EUR 774

Mouse Podoplanin(PDPN)ELISA kit

QY-E21215 96T
EUR 361

Recombinant Mouse Podoplanin (C-Fc)

CU73-10ug 10ug
EUR 131
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-500ug 500ug
EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-50ug 50ug
EUR 273
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Mouse Podoplanin, Pdpn ELISA KIT

ELI-06723m 96 Tests
EUR 865

Recombinant Podoplanin (PDPN)

4-RPC719Hu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Podoplanin expressed in: E.coli

Recombinant Podoplanin (PDPN)

4-RPC719Mu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Podoplanin expressed in: E.coli

Podoplanin (PDPN) Antibody

20-abx129101
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Podoplanin (PDPN) Antibody

20-abx131102
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Podoplanin (PDPN) Antibody

20-abx114559
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Podoplanin (PDPN) Antibody

20-abx123399
  • EUR 592.00
  • EUR 857.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 50 ul

Podoplanin (PDPN) Antibody

20-abx339428
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Podoplanin Blocking Peptide

20-abx063694
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Recombinant Human Podoplanin

7-05839 5µg Ask for price

Recombinant Human Podoplanin

7-05840 25µg Ask for price

Recombinant Human Podoplanin

7-05841 1mg Ask for price

Podoplanin (PDPN) Antibody

20-abx137407
  • EUR 704.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 20 ug
  • 5 ug

Podoplanin (PDPN) Antibody

20-abx005408
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Podoplanin (PDPN) Antibody

20-abx008317
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Podoplanin (PDPN) Antibody

abx433110-200ul 200 ul
EUR 384

Podoplanin (PDPN) Protein

20-abx262003
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

Podoplanin (PDPN) Antibody

abx236598-100ug 100 ug
EUR 551

Podoplanin (PDPN) Antibody

abx236599-100ug 100 ug
EUR 551

Podoplanin (PDPN) Antibody

20-abx211099
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Podoplanin (PDPN) Antibody

20-abx178065
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody

20-abx178066
  • EUR 1302.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody

20-abx178067
  • EUR 1414.00
  • EUR 662.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody

20-abx174125
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody

20-abx174126
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Podoplanin Conjugated Antibody

C49474 100ul
EUR 397

Podoplanin Blocking Peptide

DF12456-BP 1mg
EUR 195

Podoplanin Blocking Peptide

33R-2420 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816

Podoplanin Blocking Peptide

33R-9441 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817

Podoplanin Recombinant Protein

91-478 0.05 mg
EUR 448.25
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Podoplanin Recombinant Protein

91-788 0.05 mg
EUR 490.25
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1

CABT-L4294-1mg 1 mg
EUR 897

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1

CABT-L4294-5mg 5 mg
EUR 2405

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC

4-PAC719Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Biotinylated

4-PAC719Mu01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Biotin.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Cy3

4-PAC719Mu01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Cy3.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), FITC

4-PAC719Mu01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with FITC.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), HRP

4-PAC719Mu01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with HRP.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE

4-PAC719Mu01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE.

ELISA kit for Mouse PDPN (Podoplanin)

E-EL-M2409 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse PDPN (Podoplanin)

ELK7080 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Anti-Podoplanin Antibody Clone PDPN/1433, Unconjugated-100ug

10630-MSM1-P1 100ug
EUR 428

Rat Podoplanin (PDPN) Protein

20-abx654779
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cow Podoplanin (PDPN) Protein

20-abx654780
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Podoplanin (PDPN) Protein

20-abx166428
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Podoplanin (PDPN) Antibody (Cy3)

20-abx274445
  • EUR 551.00
  • EUR 272.00
  • EUR 1720.00
  • EUR 787.00
  • EUR 439.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Podoplanin ELISA kit

E02P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA kit

E02P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA kit

E02P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA kit

E01P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA kit

E01P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA kit

E01P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit

E07P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit

E07P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit

E07P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Podoplanin ELISA kit

E06P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Podoplanin ELISA kit

E06P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Podoplanin ELISA kit

E06P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Podoplanin ELISA kit

E04P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Podoplanin ELISA kit

E04P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Podoplanin ELISA kit

E04P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Podoplanin ELISA kit

E08P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Podoplanin ELISA kit

E08P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Podoplanin ELISA kit

E08P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit

E09P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit

E09P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit

E09P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC719Mu01-APC-Cy7
  • EUR 583.00
  • EUR 6610.00
  • EUR 1750.00
  • EUR 778.00
  • EUR 324.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC-Cy7.

Human Podoplanin (PDPN) ELISA Kit

SEC719Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Podoplanin (PDPN) in Tissue homogenates, cell lysates and other biological fluids.

Human Podoplanin (PDPN) ELISA Kit

SEC719Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Podoplanin (PDPN) in Tissue homogenates, cell lysates and other biological fluids.

Human Podoplanin (PDPN) ELISA Kit

SEC719Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Podoplanin (PDPN) in Tissue homogenates, cell lysates and other biological fluids.

Human Podoplanin (PDPN) ELISA Kit

SEC719Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Podoplanin (PDPN) in Tissue homogenates, cell lysates and other biological fluids.

Human Podoplanin (PDPN) ELISA Kit

4-SEC719Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Podoplanin (PDPN) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Podoplanin (PDPN) ELISA Kit

SEC719Ra-10x96wellstestplate 10x96-wells test plate
EUR 5124.2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Rat Podoplanin (PDPN) ELISA Kit

SEC719Ra-1x48wellstestplate 1x48-wells test plate
EUR 509.64
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Rat Podoplanin (PDPN) ELISA Kit

SEC719Ra-1x96wellstestplate 1x96-wells test plate
EUR 685.2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Rat Podoplanin (PDPN) ELISA Kit

SEC719Ra-5x96wellstestplate 5x96-wells test plate
EUR 2783.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Rat Podoplanin (PDPN) ELISA Kit

4-SEC719Ra
  • EUR 5175.00
  • EUR 2734.00
  • EUR 686.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Podoplanin(PDPN) ELISA kit

CSB-EL017739HU-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Podoplanin (PDPN) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Podoplanin(PDPN) ELISA kit

1-CSB-EL017739HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Podoplanin(PDPN) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

PDPN Podoplanin Human Recombinant Protein

PROTQ86YL7 Regular: 25ug
EUR 317
Description: PDPN Human Recombinant fused to a 20 a.a N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain (99-207 a.a) containing 130 amino acids and having a molecular mass of 13.4kDa.

Rat Podoplanin ELISA Kit (PDPN)

RK03879 96 Tests
EUR 521

Recombinant Human PDPN/Podoplanin Protein

RP00208 10 μg
EUR 155

Human Podoplanin ELISA Kit (PDPN)

RK02052 96 Tests
EUR 521

Human Podoplanin(PDPN)ELISA Kit

GA-E0156HM-48T 48T
EUR 289

Human Podoplanin(PDPN)ELISA Kit

GA-E0156HM-96T 96T
EUR 466

Bovine Podoplanin (PDPN)ELISA Kit

GA-E0006BV-48T 48T
EUR 336

Bovine Podoplanin (PDPN)ELISA Kit

GA-E0006BV-96T 96T
EUR 534

Human Podoplanin (PDPN) ELISA Kit

RD-PDPN-Hu-48Tests 48 Tests
EUR 521

Human Podoplanin (PDPN) ELISA Kit

RD-PDPN-Hu-96Tests 96 Tests
EUR 723

Rat Podoplanin (PDPN) ELISA Kit

RD-PDPN-Ra-48Tests 48 Tests
EUR 557

Rat Podoplanin (PDPN) ELISA Kit

RD-PDPN-Ra-96Tests 96 Tests
EUR 775

Human PDPN/ Podoplanin ELISA Kit

E1898Hu 1 Kit
EUR 571

Human Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.
In all circumstances, lack of weight acquire and early cerebellar signs of lack of motor management have been discovered. At termination, the one mouse sacrificed for histological research confirmed extreme, diffuse pulmonary alveolar proteinosis suggesting that pulmonary abnormalities in NPC1 mouse fashions will not be distinctive to the Npc1nih allele.

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