Eumorphia

Declined high quality and amount of sperm is presently the main reason for sufferers affected by infertility. Male germ cell growth is spatiotemporally regulated all through the entire developmental course of. Whereas it has been identified that exogenous components, similar to environmental publicity, eating regimen and life-style, et al, play causative roles in male infertility, current progress has revealed ample genetic mutations tightly related to faulty male germline growth.

In mammals, male germ cells bear dramatic morphological change (i.e., nuclear condensation) and chromatin transforming throughout post-meiotic haploid germline growth, a course of termed spermiogenesis; Nevertheless, the molecular equipment gamers and practical mechanisms have but to be recognized.

Thus far, gathered proof means that disruption in any step of haploid germline growth is probably going manifested as fertility points with low sperm rely, poor sperm motility, aberrant sperm morphology or mixed. With the regularly declined value of next-generation sequencing and up to date progress of CRISPR/Cas9 know-how, rising research have revealed an enormous variety of disease-causing genetic variants related to spermiogenic defects in each mice and people, together with mechanistic insights partially attained and validated by genetically engineered mouse fashions (GEMMs).

On this assessment, we primarily summarize genes which can be practical at post-meiotic stage. Identification and characterization of deleterious genetic variants ought to assist in our understanding of germline growth, and thereby additional enhance the analysis and therapy of male infertility.

Primarily based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a category B G protein-coupled receptor (GPCR), is a possible modulator of Alzheimer’s illness (AD) pathogenesis. Nevertheless, previous pharmacological approaches have didn’t resolve whether or not activation or blockade of this receptor would have better therapeutic profit.

To handle this situation, we generated compound mice expressing a human amyloid precursor protein gene with familial AD mutations together with deficiency of amylin receptors produced by hemizygosity for the essential calcitonin receptor subunit of this heterodimeric GPCR. These compound transgenic AD mice demonstrated attenuated responses to human amylin- and Aβ-induced melancholy of hippocampal long-term potentiation (LTP) consistent with the genetic depletion of amylin receptors.

Each the LTP responses and spatial reminiscence (as measured with Morris water maze) in these mice have been improved in comparison with AD mouse controls and, importantly, a discount in each the amyloid plaque burden and markers of neuroinflammation was noticed. Our information assist the notion of additional growth of antagonists of the amylin receptor as AD-modifying therapies.

The transcription issue IRF5 has been implicated as a therapeutic goal for the autoimmune illness systemic lupus erythematosus (SLE). Nevertheless, IRF5 activation standing through the illness course and the results of IRF5 inhibition after illness onset are unclear.

Right here, we present that SLE sufferers in each the energetic and remission part have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of kind I interferon signaling in suppressing illness in a mouse mannequin of SLE, probably because of the operate of IRF5 in oxidative phosphorylation.

We additional show that inhibition of IRF5 by way of conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after illness onset suppresses illness development and is efficient for upkeep of remission in mice. These outcomes recommend that IRF5 inhibition would possibly overcome the constraints of present SLE therapies, thus selling drug discovery analysis on IRF5 inhibitors.

Genetic components underlying the human limb abnormality congenital talipes equinovarus (‘clubfoot’) stay incompletely understood. The spontaneous autosomal recessive mouse ‘peroneal muscular atrophy’ mutant (PMA) is a trustworthy morphological mannequin of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent.

On this examine, the first developmental defect was recognized as a lowered progress of sciatic nerve lateral motor column (LMC) neurons resulting in failure to challenge to dorsal (peroneal) decrease limb muscle blocks. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) recognized, which is upregulated in mutant lateral LMC motor neurons.

Genetic and molecular analyses confirmed that the mutation acts within the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate progress cone extension/collapse. Within the hen, each experimental upregulation of Limk1 by electroporation and pharmacological inhibition of actin turnover led to defects in hindlimb spinal motor neuron progress and pathfinding, and mimicked the clubfoot phenotype. The info assist a neuromuscular aetiology for clubfoot and supply a mechanistic framework to grasp clubfoot in people.

Macrophages are innate immune cells that continually patrol an organism to meet protecting and homeostatic roles. Earlier research have proven that Rho GTPase exercise is required for macrophage mobility, but the roles of upstream regulatory proteins controlling Rho GTPase operate in these cells will not be effectively outlined.

Beforehand we’ve got proven that the RhoA GEF Net1 is required for human breast most cancers cell motility and extracellular matrix invasion. To evaluate the function of Net1 in macrophage motility, we remoted bone marrow macrophage (BMM) precursors from wild kind and Net1 knockout mice.

Lack of Net1 didn’t have an effect on the power of BMM precursors to distinguish into mature macrophages in vitro, as measured by CD68 and F4/80 staining. Nevertheless, Net1 deletion considerably lowered RhoA activation, F-actin accumulation, adhesion, and motility in these cells.

Nonetheless, just like RhoA/RhoB double knockout macrophages, Net1 deletion didn’t impair macrophage recruitment to the peritoneum in a mouse mannequin of sterile irritation. These information show that Net1 is a vital regulator of RhoA signaling and motility in mouse macrophages in vitro, however that its operate could also be dispensable for macrophage recruitment to inflammatory websites in vivo.

The Npc1nmf164 allele of Npc1 gives a mouse mannequin for Niemann-Decide illness kind C1 (NPC1), a genetic illness identified to have a extensively variable phenotype.

The switch of the Npc1nmf164 mutation from the C57BL/6J inbred pressure to the BALB/cJ inbred pressure elevated the imply lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background.

The switch of one other Npc1 allele, Npc1nih, to this background additionally prolonged survival of the homozygotes indicating that the modifying impact of BALB/cJ isn’t restricted to a single allele of Npc1. The elevated longevity because of the BALB/cJ background didn’t map to a beforehand mapped modifier on chromosome 19, indicating the presence of extra genes impacting illness severity.

The beforehand studied Glial Fibrillary Acidic Protein promoter-Npc1 cDNA transgene (GFAP-Npc1) which solely expresses NPC1 in astrocytes additional prolonged the lifespan of Npc1nmf164 homozygotes on a BALB/cJ background (as much as 600days). Hydroxypropyl-β-cyclodextrin (HPβCD) therapy, not beforehand examined within the Npc1nmf164 mutant, prolonged life within the Npc1nmf164 homozygotes however not the transgenic, Npc1nmf164 mice on the BALB/cJ background.

Mouse Podoplanin (PDPN) ELISA Kit
20-abx154564	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Mouse Podoplanin (PDPN) ELISA Kit
abx571749-96tests	Abbexa	96 tests	EUR 943.2

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-48T	DL Develop	48T	EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-96T	DL Develop	96T	EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin, Pdpn ELISA KIT
ELI-06723m	Lifescience Market	96 Tests	EUR 1038

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
4-SEC719Mu	Cloud-Clone	EUR 5895.60 EUR 3114.00 EUR 786.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-48Tests	Reddot Biotech	48 Tests	EUR 639.6

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-96Tests	Reddot Biotech	96 Tests	EUR 888

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-48Tests	Reddot Biotech	48 Tests	EUR 668.4

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-96Tests	Reddot Biotech	96 Tests	EUR 928.8

Mouse Podoplanin(PDPN)ELISA kit
QY-E21215	Qayee Biotechnology	96T	EUR 433.2

Mouse Podoplanin (PDPN) ELISA Kit
DL-PDPN-Mu	DL Develop	96T	EUR 453
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu	DL Develop	96T	EUR 475
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-48T	Reddot Biotech	48T	EUR 487.52
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-96T	Reddot Biotech	96T	EUR 696.47
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-48T	Reddot Biotech	48T	EUR 464.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-96T	Reddot Biotech	96T	EUR 663.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN)ELISA kit
YLA0596MO-48T	Shanghai YL Biotech	48T	EUR 465

Mouse Podoplanin (PDPN)ELISA kit
YLA0596MO-96T	Shanghai YL Biotech	96T	EUR 600

Podoplanin
MO47016	Neuromics	100 ul	EUR 418.8

Podoplanin
E8ET1703-61	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Podoplanin
E8ER1915-23	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Recombinant Mouse Podoplanin (C-Fc)
CU73-1mg	Novoprotein	1mg	EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-500ug	Novoprotein	500ug	EUR 1399.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-50ug	Novoprotein	50ug	EUR 327.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-10ug	Novoprotein	10ug	EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse)
4-PAC719Mu01	Cloud-Clone	EUR 301.20 EUR 3091.20 EUR 768.00 EUR 379.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN)

Podoplanin antibody
10R-7662	Fitzgerald	100 ug	EUR 754.8
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-7663	Fitzgerald	100 ug	EUR 754.8
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
10R-7664	Fitzgerald	100 ug	EUR 754.8
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-P133a	Fitzgerald	100 ug	EUR 608.4
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-P155a	Fitzgerald	100 ug	EUR 651.6
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
70R-PR007	Fitzgerald	100 ug	EUR 506.4
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-11540	Fitzgerald	100 ug	EUR 632.4
Description: Rabbit polyclonal Podoplanin antibody

Podoplanin Antibody
49474-100ul	SAB	100ul	EUR 399.6

Podoplanin Antibody
49474-50ul	SAB	50ul	EUR 286.8

Podoplanin antibody
70R-13952	Fitzgerald	100 ug	EUR 366
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-6816	Fitzgerald	50 ug	EUR 560.4
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN

Podoplanin antibody
70R-6817	Fitzgerald	50 ug	EUR 560.4
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN

Podoplanin antibody
70R-50819	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal Podoplanin antibody

Podoplanin Antibody
P1051-01m	SAB	0.1m	EUR 250.8

Podoplanin Antibody
P1051-1ml	SAB	1ml	EUR 1129.2

Podoplanin Antibody
R33852-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: PDPN; AGGRUS; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26

Podoplanin Antibody
R20464-0.1ML	NSJ Bioreagents	100ul	EUR 409

Podoplanin Antibody
E38PA2500	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Podoplanin Antibody
DF12456-100ul	Affinity Biosciences	100ul	EUR 280

Podoplanin Antibody
DF12456-200ul	Affinity Biosciences	200ul	EUR 350

Podoplanin Antibody
DF12456	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse

ELISA kit for Mouse PDPN (Podoplanin)
E-EL-M2409	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse PDPN (Podoplanin)
ELK7080	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE
4-PAC719Mu01-PE	Cloud-Clone	EUR 361.20 EUR 3254.40 EUR 921.60 EUR 454.80 EUR 236.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE.

Anti-D2-40/Podoplanin antibody
STJ190048	St John's Laboratory	200 µl	EUR 236.4
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1)

Anti-D2-40 Podoplanin antibody
STJ16100360	St John's Laboratory	1 mL	EUR 1482

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC
4-PAC719Mu01-APC	Cloud-Clone	EUR 421.20 EUR 4038.00 EUR 1122.00 EUR 538.80 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Cy3
4-PAC719Mu01-Cy3	Cloud-Clone	EUR 512.40 EUR 5334.00 EUR 1446.00 EUR 668.40 EUR 304.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Cy3.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), HRP
4-PAC719Mu01-HRP	Cloud-Clone	EUR 385.20 EUR 3519.60 EUR 992.40 EUR 486.00 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with HRP.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), FITC
4-PAC719Mu01-FITC	Cloud-Clone	EUR 361.20 EUR 3254.40 EUR 921.60 EUR 454.80 EUR 236.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with FITC.

Podoplanin (PDPN) Antibody
20-abx137407	Abbexa	EUR 844.80 EUR 393.60 EUR 276.00	100 ug 20 ug 5 ug

Podoplanin (PDPN) Antibody
abx236598-100ug	Abbexa	100 ug	EUR 661.2

Podoplanin (PDPN) Antibody
abx236599-100ug	Abbexa	100 ug	EUR 661.2

Podoplanin (PDPN) Antibody
20-abx174125	Abbexa	EUR 1028.40 EUR 526.80	1 mg 200 ug

Podoplanin (PDPN) Antibody
20-abx174126	Abbexa	EUR 1095.60 EUR 560.40	1 mg 200 ug

Podoplanin (PDPN) Antibody
20-abx178065	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Podoplanin (PDPN) Antibody
20-abx178066	Abbexa	EUR 1562.40 EUR 744.00	1 mg 200 ug

Podoplanin (PDPN) Antibody
20-abx178067	Abbexa	EUR 1696.80 EUR 794.40	1 mg 200 ug

Podoplanin (PDPN) Antibody
20-abx211099	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Podoplanin (PDPN) Antibody
20-abx114559	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Podoplanin (PDPN) Antibody
20-abx129101	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Podoplanin (PDPN) Antibody
20-abx131102	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Podoplanin (PDPN) Antibody
20-abx123399	Abbexa	EUR 710.40 EUR 1028.40 EUR 493.20	100 ul 200 ul 50 ul

Podoplanin (PDPN) Antibody
20-abx339428	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Podoplanin (PDPN) Antibody
abx433110-200ul	Abbexa	200 ul	EUR 460.8

Podoplanin (PDPN) Antibody
20-abx005408	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Podoplanin (PDPN) Antibody
20-abx008317	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Podoplanin Antibody gp36
R30481	NSJ Bioreagents	100 ug	EUR 356.15
Description: Podoplanin is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the gene to chromosome 1. It is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury.

Podoplanin Antibody / gp36
R30760	NSJ Bioreagents	100 ug	EUR 356.15
Description: PDPN (Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells.

Podoplanin Antibody / gp36
V3404-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Podoplanin Antibody / gp36
V3404-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Podoplanin Antibody / gp36
V3404SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Pdpn Antibody /Podoplanin
RQ6390	NSJ Bioreagents	100 ug	EUR 356.15
Description: Podoplanin (PDPN) is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the T1A gene to chromosome 1. It has got 162 amino acid protein which is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. Northern blot analysis detected a 1.2-kb T1A2 transcript only in lung. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury.

Podoplanin Antibody / gp36
V8695-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Podoplanin Antibody / gp36
V8695-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Podoplanin Antibody / gp36
V8695SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761
CABT-L2919-100uL500uL	Creative Diagnostics	100 uL, 500 uL	EUR 602.4

Podoplanin Rabbit pAb
E2381729	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Podoplanin Rabbit pAb
E2381779	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Podoplanin rabbit pAb
E28PT7965	EnoGene	100μl	EUR 255
Description: Available in various conjugation types.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC719Mu01-APC-Cy7	Cloud-Clone	EUR 699.60 EUR 7932.00 EUR 2100.00 EUR 933.60 EUR 388.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC-Cy7.

Podoplanin (PDPN) Antibody (Cy3)
20-abx274445	Abbexa	EUR 661.20 EUR 326.40 EUR 2064.00 EUR 944.40 EUR 526.80	100 ug 10 ug 1 mg 200 ug 50 ug

Podoplanin Antibody (IHC Gold)
E36PA650	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Podoplanin (PDPN) Protein
20-abx262003	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 25 ug 5 ug

Podoplanin Conjugated Antibody
C49474	SAB	100ul	EUR 476.4

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Biotinylated
4-PAC719Mu01-Biotin	Cloud-Clone	EUR 379.20 EUR 3031.20 EUR 892.80 EUR 464.40 EUR 265.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Biotin.

Dog Podoplanin ELISA kit
E08P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Podoplanin ELISA kit
E08P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Podoplanin ELISA kit
E08P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA kit
E02P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA kit
E02P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA kit
E02P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit
E07P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit
E07P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Podoplanin ELISA kit
E07P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Podoplanin ELISA Kit
IRTPDPNKT	Innovative research	each	EUR 790
Description: Rat Podoplanin ELISA Kit

Goat Podoplanin ELISA kit
E06P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Podoplanin ELISA kit
E06P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Podoplanin ELISA kit
E06P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Podoplanin Blocking Peptide
20-abx063694	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

Podoplanin Blocking Peptide
33R-2420	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816

Podoplanin Blocking Peptide
33R-9441	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817

Podoplanin Blocking Peptide
DF12456-BP	Affbiotech	1mg	EUR 234

Recombinant Podoplanin (PDPN)
4-RPC719Hu01	Cloud-Clone	EUR 496.32 EUR 256.80 EUR 1531.20 EUR 590.40 EUR 1060.80 EUR 408.00 EUR 3648.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Podoplanin expressed in: E.coli

Recombinant Podoplanin (PDPN)
4-RPC719Mu01	Cloud-Clone	EUR 550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Podoplanin expressed in: E.coli

Human Podoplanin ELISA kit
E01P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA kit
E01P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA kit
E01P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Podoplanin ELISA Kit
IHUPDPNKT	Innovative research	each	EUR 733
Description: Human Podoplanin ELISA Kit

Podoplanin / GP36 / T1A-2 Antibody
abx031419-400ul	Abbexa	400 ul	EUR 627.6

Podoplanin / GP36 / T1A-2 Antibody
abx031419-80l	Abbexa	80 µl	EUR 343.2

Recombinant Human Podoplanin
7-05839	CHI Scientific	5µg	Ask for price

Recombinant Human Podoplanin
7-05840	CHI Scientific	25µg	Ask for price

Recombinant Human Podoplanin
7-05841	CHI Scientific	1mg	Ask for price

Rat Podoplanin (PDPN) Protein
20-abx654779	Abbexa	EUR 693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00	100 ug 10 ug 1 mg 200 ug 50 ug

Cow Podoplanin (PDPN) Protein
20-abx654780	Abbexa	EUR 777.60 EUR 326.40 EUR 2397.60 EUR 927.60 EUR 560.40	100 ug 10 ug 1 mg 200 ug 50 ug

Rabbit Podoplanin ELISA kit
E04P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Podoplanin ELISA kit
E04P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Podoplanin ELISA kit
E04P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit
E09P0082-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit
E09P0082-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Podoplanin ELISA kit
E09P0082-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Podoplanin Recombinant Protein
91-478	ProSci	0.05 mg	EUR 537.9
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Podoplanin Recombinant Protein
91-788	ProSci	0.05 mg	EUR 588.3
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Rat Podoplanin (PDPN) CLIA Kit
20-abx493859	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Human Podoplanin (PDPN) Protein
20-abx166428	Abbexa	EUR 693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Podoplanin (PDPN) ELISA Kit
abx255914-96tests	Abbexa	96 tests	EUR 848.4

Rat Podoplanin (PDPN) ELISA Kit
20-abx155993	Abbexa	EUR 8684.40 EUR 4626.00 EUR 1074.00	10 × 96 tests 5 × 96 tests 96 tests

Rat Podoplanin (PDPN) ELISA Kit
abx570903-96tests	Abbexa	96 tests	EUR 848.4

Pig Podoplanin (PDPN) ELISA Kit
abx360730-96tests	Abbexa	96 tests	EUR 990

Dog Podoplanin (PDPN) ELISA Kit
abx519384-96tests	Abbexa	96 tests	EUR 1093.2

Rat Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Ra-48T	DL Develop	48T	EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Ra-96T	DL Develop	96T	EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat PDPN(Podoplanin) ELISA Kit
ER1249	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rat Podoplanin, Pdpn ELISA KIT
ELI-06726r	Lifescience Market	96 Tests	EUR 1063.2

Rat Podoplanin (PDPN) ELISA Kit
SEC719Ra-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6149.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

In all circumstances, lack of weight acquire and early cerebellar signs of lack of motor management have been discovered. At termination, the one mouse sacrificed for histological research confirmed extreme, diffuse pulmonary alveolar proteinosis suggesting that pulmonary abnormalities in NPC1 mouse fashions will not be distinctive to the Npc1nih allele.