Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models
Declined high quality and amount of sperm is presently the main reason for sufferers affected by infertility. Male germ cell growth is spatiotemporally regulated all through the entire developmental course of. Whereas it has been identified that exogenous components, similar to environmental publicity, eating regimen and life-style, et al, play causative roles in male infertility, current progress has revealed ample genetic mutations tightly related to faulty male germline growth.
In mammals, male germ cells bear dramatic morphological change (i.e., nuclear condensation) and chromatin transforming throughout post-meiotic haploid germline growth, a course of termed spermiogenesis; Nevertheless, the molecular equipment gamers and practical mechanisms have but to be recognized.
Thus far, gathered proof means that disruption in any step of haploid germline growth is probably going manifested as fertility points with low sperm rely, poor sperm motility, aberrant sperm morphology or mixed. With the regularly declined value of next-generation sequencing and up to date progress of CRISPR/Cas9 know-how, rising research have revealed an enormous variety of disease-causing genetic variants related to spermiogenic defects in each mice and people, together with mechanistic insights partially attained and validated by genetically engineered mouse fashions (GEMMs).
On this assessment, we primarily summarize genes which can be practical at post-meiotic stage. Identification and characterization of deleterious genetic variants ought to assist in our understanding of germline growth, and thereby additional enhance the analysis and therapy of male infertility.
Genetic Depletion of Amylin/Calcitonin Receptors Improves Reminiscence and Studying in Transgenic Alzheimer’s Illness Mouse Fashions
Primarily based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a category B G protein-coupled receptor (GPCR), is a possible modulator of Alzheimer’s illness (AD) pathogenesis. Nevertheless, previous pharmacological approaches have didn’t resolve whether or not activation or blockade of this receptor would have better therapeutic profit.
To handle this situation, we generated compound mice expressing a human amyloid precursor protein gene with familial AD mutations together with deficiency of amylin receptors produced by hemizygosity for the essential calcitonin receptor subunit of this heterodimeric GPCR. These compound transgenic AD mice demonstrated attenuated responses to human amylin- and Aβ-induced melancholy of hippocampal long-term potentiation (LTP) consistent with the genetic depletion of amylin receptors.
Each the LTP responses and spatial reminiscence (as measured with Morris water maze) in these mice have been improved in comparison with AD mouse controls and, importantly, a discount in each the amyloid plaque burden and markers of neuroinflammation was noticed. Our information assist the notion of additional growth of antagonists of the amylin receptor as AD-modifying therapies.
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like illness
The transcription issue IRF5 has been implicated as a therapeutic goal for the autoimmune illness systemic lupus erythematosus (SLE). Nevertheless, IRF5 activation standing through the illness course and the results of IRF5 inhibition after illness onset are unclear.
Right here, we present that SLE sufferers in each the energetic and remission part have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of kind I interferon signaling in suppressing illness in a mouse mannequin of SLE, probably because of the operate of IRF5 in oxidative phosphorylation.
We additional show that inhibition of IRF5 by way of conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after illness onset suppresses illness development and is efficient for upkeep of remission in mice. These outcomes recommend that IRF5 inhibition would possibly overcome the constraints of present SLE therapies, thus selling drug discovery analysis on IRF5 inhibitors.
The developmental and genetic foundation of ‘clubfoot’ within the peroneal muscular atrophy mutant mouse.
Genetic components underlying the human limb abnormality congenital talipes equinovarus (‘clubfoot’) stay incompletely understood. The spontaneous autosomal recessive mouse ‘peroneal muscular atrophy’ mutant (PMA) is a trustworthy morphological mannequin of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent.
On this examine, the first developmental defect was recognized as a lowered progress of sciatic nerve lateral motor column (LMC) neurons resulting in failure to challenge to dorsal (peroneal) decrease limb muscle blocks. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) recognized, which is upregulated in mutant lateral LMC motor neurons.
Genetic and molecular analyses confirmed that the mutation acts within the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate progress cone extension/collapse. Within the hen, each experimental upregulation of Limk1 by electroporation and pharmacological inhibition of actin turnover led to defects in hindlimb spinal motor neuron progress and pathfinding, and mimicked the clubfoot phenotype. The info assist a neuromuscular aetiology for clubfoot and supply a mechanistic framework to grasp clubfoot in people.
Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal group.
Macrophages are innate immune cells that continually patrol an organism to meet protecting and homeostatic roles. Earlier research have proven that Rho GTPase exercise is required for macrophage mobility, but the roles of upstream regulatory proteins controlling Rho GTPase operate in these cells will not be effectively outlined.
Beforehand we’ve got proven that the RhoA GEF Net1 is required for human breast most cancers cell motility and extracellular matrix invasion. To evaluate the function of Net1 in macrophage motility, we remoted bone marrow macrophage (BMM) precursors from wild kind and Net1 knockout mice.
Lack of Net1 didn’t have an effect on the power of BMM precursors to distinguish into mature macrophages in vitro, as measured by CD68 and F4/80 staining. Nevertheless, Net1 deletion considerably lowered RhoA activation, F-actin accumulation, adhesion, and motility in these cells.
Nonetheless, just like RhoA/RhoB double knockout macrophages, Net1 deletion didn’t impair macrophage recruitment to the peritoneum in a mouse mannequin of sterile irritation. These information show that Net1 is a vital regulator of RhoA signaling and motility in mouse macrophages in vitro, however that its operate could also be dispensable for macrophage recruitment to inflammatory websites in vivo.
In Niemann-Decide C1 mouse fashions, glial-only expression of the traditional gene extends survival a lot additional than do modifications in genetic background or therapy with hydroxypropyl-beta-cyclodextrin.
The Npc1nmf164 allele of Npc1 gives a mouse mannequin for Niemann-Decide illness kind C1 (NPC1), a genetic illness identified to have a extensively variable phenotype.
The switch of the Npc1nmf164 mutation from the C57BL/6J inbred pressure to the BALB/cJ inbred pressure elevated the imply lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background.
The switch of one other Npc1 allele, Npc1nih, to this background additionally prolonged survival of the homozygotes indicating that the modifying impact of BALB/cJ isn’t restricted to a single allele of Npc1. The elevated longevity because of the BALB/cJ background didn’t map to a beforehand mapped modifier on chromosome 19, indicating the presence of extra genes impacting illness severity.
The beforehand studied Glial Fibrillary Acidic Protein promoter-Npc1 cDNA transgene (GFAP-Npc1) which solely expresses NPC1 in astrocytes additional prolonged the lifespan of Npc1nmf164 homozygotes on a BALB/cJ background (as much as 600days). Hydroxypropyl-β-cyclodextrin (HPβCD) therapy, not beforehand examined within the Npc1nmf164 mutant, prolonged life within the Npc1nmf164 homozygotes however not the transgenic, Npc1nmf164 mice on the BALB/cJ background.
Mouse Anti-Rat Podoplanin |
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| MBS690143-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Hamster anti Podoplanin (mouse) |
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| 103-M40 | Angio Proteomie | 100ug | EUR 297.6 |
Mouse Anti-Human Podoplanin |
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| MBS690117-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
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| MBS690117-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
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| MBS690586-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS690586-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690680-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
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| MBS690680-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
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| MBS690759-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS690759-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690992-005mg | MyBiosource | 0.05mg | EUR 430 |
Mouse Anti-Human Podoplanin |
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| MBS690992-5x005mg | MyBiosource | 5x0.05mg | EUR 1645 |
Mouse Anti-Human Podoplanin |
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| MBS692357-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS692357-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS692358-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS692358-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse anti Podoplanin-Biotin (human) |
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| 101-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Hamster anti Podoplanin-Biotin (mouse) |
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| 103-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Podoplanin Mouse mAb |
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| A18776 | Abclonal | 100μL | EUR 719.13 |
Podoplanin Mouse mAb |
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| E47M34236 | EnoGene | 100ul | EUR 295 |
Mouse Podoplanin, soluble |
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| MBS691731-0005mg | MyBiosource | 0.005mg | EUR 250 |
Mouse Podoplanin, soluble |
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| MBS691731-5x0005mg | MyBiosource | 5x0.005mg | EUR 835 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
Anti-Human/Mouse PDPN/Podoplanin Antibody |
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| MBS1569238-01mg | MyBiosource | 0.1mg | EUR 405 |
Anti-Human/Mouse PDPN/Podoplanin Antibody |
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| MBS1569238-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
Recombinant Mouse Podoplanin |
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| MBS7610672-005mg | MyBiosource | 0.05mg | EUR 345 |
Recombinant Mouse Podoplanin |
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| MBS7610672-02mg | MyBiosource | 0.2mg | EUR 635 |
Recombinant Mouse Podoplanin |
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| MBS7610672-1mg | MyBiosource | 1mg | EUR 1800 |
Recombinant Mouse Podoplanin |
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| MBS7610672-5x1mg | MyBiosource | 5x1mg | EUR 6955 |
Mouse Monoclonal anti-Rat Podoplanin Antibody |
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| xAP-0897 | Angio Proteomie | 100ug | EUR 280 |
Mouse Podoplanin ELISA kit |
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| E01A24381 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Podoplanin ELISA kit |
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| E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Podoplanin ELISA kit |
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| E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Podoplanin ELISA Kit |
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| IMSPDPNKT | Innovative research | each | EUR 752 |
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Description: Mouse Podoplanin ELISA Kit |
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Mouse Podoplanin ELISA Kit |
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| MBS2884556-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4080 |
Mouse Podoplanin ELISA Kit |
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| MBS2884556-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
Mouse Podoplanin ELISA Kit |
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| MBS2884556-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2220 |
Mouse Podoplanin ELISA Kit |
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| MBS2884556-96StripWells | MyBiosource | 96-Strip-Wells | EUR 520 |
Mouse Podoplanin ELISA Kit |
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| MBS725552-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Podoplanin ELISA Kit |
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| MBS725552-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Podoplanin ELISA Kit |
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| MBS725552-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Podoplanin ELISA Kit |
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| MBS725552-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Hamster Anti-Mouse Podoplanin |
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| MBS690646-01mg | MyBiosource | 0.1mg | EUR 450 |
Hamster Anti-Mouse Podoplanin |
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| MBS690646-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Hamster Anti-Mouse Podoplanin |
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| MBS690790-005mg | MyBiosource | 0.05mg | EUR 430 |
Hamster Anti-Mouse Podoplanin |
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| MBS690790-5x005mg | MyBiosource | 5x0.05mg | EUR 1645 |
Anti-Mouse Podoplanin Antibody |
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| 103-M552 | ReliaTech | 100 µg | EUR 399 |
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Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
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Anti-Mouse Podoplanin Antibody |
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| 103-PA40 | ReliaTech | 200 µg | EUR 204.75 |
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Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
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Anti-Mouse Podoplanin Antibody |
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| 103-PA40S | ReliaTech | 100 µg | EUR 126 |
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Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
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Mouse Podoplanin (PDPN) Protein |
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| abx694266-10nmol | Abbexa | 10 nmol | EUR 700 |
Mouse Podoplanin (PDPN) Protein |
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| abx694266-5nmol | Abbexa | 5 nmol | EUR 462.5 |
Mouse Podoplanin (PDPN) Protein |
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| abx650139-100g | Abbexa | 100 µg | EUR 537.5 |
Mouse Podoplanin (PDPN) Protein |
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| 20-abx650139 | Abbexa |
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Mouse Podoplanin (PDPN) Protein |
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| abx650139-10g | Abbexa | 10 µg | EUR 212.5 |
Mouse Podoplanin (PDPN) Protein |
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| abx650139-50g | Abbexa | 50 µg | EUR 375 |
Podoplanin (ABT360) Mouse mAb |
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| UB-GEN-15155 | UpingBio | 100 ul | EUR 200 |
Podoplanin (ABT513) Mouse mAb |
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| UB-GEN-14883 | UpingBio | 100 ul | EUR 200 |
Mouse Monoclonal Podoplanin Antibody |
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| TA327727 | Origene Technologies GmbH | 1 ml | Ask for price |
Mouse Podoplanin (PDPN) CLIA Kit |
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| 20-abx493858 | Abbexa |
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ELISA Kit for Mouse Podoplanin |
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| E2095m | EIAab | 96T | EUR 387.4 |
anti- Podoplanin antibody |
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| FNab06598 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Podoplanin |
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anti- Podoplanin antibody |
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| FNab06599 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Podoplanin |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| abx571749-96tests | Abbexa | 96 tests | EUR 587.5 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| DL-PDPN-Mu | DL Develop | 96T | EUR 453 |
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Description: tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu | DL Develop | 96T | EUR 475 |
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Description: tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu-96T | DL Develop | 96T | EUR 825.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| 20-abx154564 | Abbexa |
|
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Mouse Podoplanin (PDPN) ELISA Kit |
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| AE28131MO-48T | Abebio | 48T | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| AE28131MO-48Tests | Abebio | 48 Tests | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| AE28131MO-96T | Abebio | 96T | EUR 610 |
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Description: Mouse (Mus musculus) |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| AE28131MO-96Tests | Abebio | 96 Tests | EUR 610 |
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Description: Mouse (Mus musculus) |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| EKU06727-48T | Biomatik Corporation | 48T | EUR 571.55 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EKU06727-5x96T | Biomatik Corporation | 5x96T | EUR 3878.38 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EKU06727-96T | Biomatik Corporation | 96T | EUR 816.5 |
Mouse Podoplanin,PDPN ELISA KIT |
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| E1437Mo-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Mouse Podoplanin,PDPN ELISA KIT |
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| E1437Mo-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Mouse Podoplanin,PDPN ELISA KIT |
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| E1437Mo-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Mouse Podoplanin,PDPN ELISA KIT |
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| E1437Mo-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Mouse Podoplanin,PDPN ELISA KIT |
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| JOT-EK1437Mo | Jotbody | 96 wells | Ask for price |
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Description: Mouse |
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Mouse Podoplanin, Pdpn ELISA KIT |
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| ELI-06723m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EKN47838-48T | Biomatik Corporation | 48T | EUR 389.62 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EKN47838-5x96T | Biomatik Corporation | 5x96T | EUR 2643.85 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EKN47838-96T | Biomatik Corporation | 96T | EUR 556.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| EK8596 | SAB | 96Т | EUR 799 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS1601033-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3955 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS1601033-48StripWells | MyBiosource | 48-Strip-Wells | EUR 305 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS1601033-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2005 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS1601033-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS4501762-10x96Tests | MyBiosource | 10x96Tests | EUR 5375 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS4501762-48Tests | MyBiosource | 48Tests | EUR 470 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS4501762-5x96Tests | MyBiosource | 5x96Tests | EUR 2755 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS4501762-96Test | MyBiosource | 96Test | EUR 620 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2020020-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5455 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2020020-24StripWells | MyBiosource | 24-Strip-Wells | EUR 365 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2020020-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2020020-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2985 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2020020-96StripWells | MyBiosource | 96-Strip-Wells | EUR 740 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS455766-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5160 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS455766-48StripWells | MyBiosource | 48-Strip-Wells | EUR 450 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS455766-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2645 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS455766-96StripWells | MyBiosource | 96-Strip-Wells | EUR 595 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2803565-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6255 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2803565-48StripWells | MyBiosource | 48-Strip-Wells | EUR 445 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS2803565-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3290 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2803565-96StripWells | MyBiosource | 96-Strip-Wells | EUR 730 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2704635-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3215 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2704635-24StripWells | MyBiosource | 24-Strip-Wells | EUR 255 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2704635-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2704635-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1675 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| MBS2704635-96StripWells | MyBiosource | 96-Strip-Wells | EUR 430 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS9309796-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS9309796-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS9309796-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| MBS9309796-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RK13459 | Abclonal | 96T | EUR 322.37 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 511 |
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Description: sandwich |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 731 |
|
Description: sandwich |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 928.8 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5834.88 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 585.7 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 785.28 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
|||
| SEC719Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3173.76 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
|||
| 4-SEC719Mu | Cloud-Clone |
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Mouse Podoplanin (PDPN) ELISA Kit |
|||
| RD-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 487 |
|
Description: sandwich |
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Mouse Podoplanin (PDPN) ELISA Kit |
|||
| RD-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| RD-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 696 |
|
Description: sandwich |
|||
Mouse Podoplanin (PDPN) ELISA Kit |
|||
| RD-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 888 |
Mouse Podoplanin (PDPN)ELISA kit |
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| YLA0596MO-48T | Shanghai YL Biotech | 48T | Ask for price |
Mouse Podoplanin (PDPN)ELISA kit |
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| YLA0596MO-96T | Shanghai YL Biotech | 96T | Ask for price |
Mouse PDPN (Podoplanin) ELISA Kit |
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| EKE61859-5x96T | Biomatik Corporation | 5x96T | EUR 3124.08 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| EKE61859-96T | Biomatik Corporation | 96T | EUR 657.7 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS2516017-10x96Tests | MyBiosource | 10x96Tests | EUR 4060 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS2516017-24Tests | MyBiosource | 24Tests | EUR 265 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS2516017-48Test | MyBiosource | 48Test | EUR 450 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS2516017-5x96Test | MyBiosource | 5x96Test | EUR 2265 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS2516017-96Tests | MyBiosource | 96Tests | EUR 535 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS8806057-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS8806057-48StripWells | MyBiosource | 48-Strip-Wells | EUR 350 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS8806057-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Mouse PDPN (Podoplanin) ELISA Kit |
|||
| MBS8806057-96StripWells | MyBiosource | 96-Strip-Wells | EUR 445 |
Mouse PDPN(Podoplanin) ELISA Kit |
|||
| RE2052M-48wells | Reed Biotech | 48 wells | EUR 116.55 |
Mouse PDPN(Podoplanin) ELISA Kit |
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| RE2052M-48wellsplate | Reed Biotech | 48-wells plate | EUR 126 |
In all circumstances, lack of weight acquire and early cerebellar signs of lack of motor management have been discovered. At termination, the one mouse sacrificed for histological research confirmed extreme, diffuse pulmonary alveolar proteinosis suggesting that pulmonary abnormalities in NPC1 mouse fashions will not be distinctive to the Npc1nih allele.
