Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Declined high quality and amount of sperm is presently the main reason for sufferers affected by infertility. Male germ cell growth is spatiotemporally regulated all through the entire developmental course of. Whereas it has been identified that exogenous components, similar to environmental publicity, eating regimen and life-style, et al, play causative roles in male infertility, current progress has revealed ample genetic mutations tightly related to faulty male germline growth.
In mammals, male germ cells bear dramatic morphological change (i.e., nuclear condensation) and chromatin transforming throughout post-meiotic haploid germline growth, a course of termed spermiogenesis; Nevertheless, the molecular equipment gamers and practical mechanisms have but to be recognized.
Thus far, gathered proof means that disruption in any step of haploid germline growth is probably going manifested as fertility points with low sperm rely, poor sperm motility, aberrant sperm morphology or mixed. With the regularly declined value of next-generation sequencing and up to date progress of CRISPR/Cas9 know-how, rising research have revealed an enormous variety of disease-causing genetic variants related to spermiogenic defects in each mice and people, together with mechanistic insights partially attained and validated by genetically engineered mouse fashions (GEMMs).
On this assessment, we primarily summarize genes which can be practical at post-meiotic stage. Identification and characterization of deleterious genetic variants ought to assist in our understanding of germline growth, and thereby additional enhance the analysis and therapy of male infertility.

Genetic Depletion of Amylin/Calcitonin Receptors Improves Reminiscence and Studying in Transgenic Alzheimer’s Illness Mouse Fashions

Primarily based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a category B G protein-coupled receptor (GPCR), is a possible modulator of Alzheimer’s illness (AD) pathogenesis. Nevertheless, previous pharmacological approaches have didn’t resolve whether or not activation or blockade of this receptor would have better therapeutic profit.
To handle this situation, we generated compound mice expressing a human amyloid precursor protein gene with familial AD mutations together with deficiency of amylin receptors produced by hemizygosity for the essential calcitonin receptor subunit of this heterodimeric GPCR. These compound transgenic AD mice demonstrated attenuated responses to human amylin- and Aβ-induced melancholy of hippocampal long-term potentiation (LTP) consistent with the genetic depletion of amylin receptors.
Each the LTP responses and spatial reminiscence (as measured with Morris water maze) in these mice have been improved in comparison with AD mouse controls and, importantly, a discount in each the amyloid plaque burden and markers of neuroinflammation was noticed. Our information assist the notion of additional growth of antagonists of the amylin receptor as AD-modifying therapies.

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like illness

The transcription issue IRF5 has been implicated as a therapeutic goal for the autoimmune illness systemic lupus erythematosus (SLE). Nevertheless, IRF5 activation standing through the illness course and the results of IRF5 inhibition after illness onset are unclear.
Right here, we present that SLE sufferers in each the energetic and remission part have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of kind I interferon signaling in suppressing illness in a mouse mannequin of SLE, probably because of the operate of IRF5 in oxidative phosphorylation.
We additional show that inhibition of IRF5 by way of conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after illness onset suppresses illness development and is efficient for upkeep of remission in mice. These outcomes recommend that IRF5 inhibition would possibly overcome the constraints of present SLE therapies, thus selling drug discovery analysis on IRF5 inhibitors.

The developmental and genetic foundation of ‘clubfoot’ within the peroneal muscular atrophy mutant mouse.

Genetic components underlying the human limb abnormality congenital talipes equinovarus (‘clubfoot’) stay incompletely understood. The spontaneous autosomal recessive mouse ‘peroneal muscular atrophy’ mutant (PMA) is a trustworthy morphological mannequin of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent.
On this examine, the first developmental defect was recognized as a lowered progress of sciatic nerve lateral motor column (LMC) neurons resulting in failure to challenge to dorsal (peroneal) decrease limb muscle blocks. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) recognized, which is upregulated in mutant lateral LMC motor neurons.
Genetic and molecular analyses confirmed that the mutation acts within the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate progress cone extension/collapse. Within the hen, each experimental upregulation of Limk1 by electroporation and pharmacological inhibition of actin turnover led to defects in hindlimb spinal motor neuron progress and pathfinding, and mimicked the clubfoot phenotype. The info assist a neuromuscular aetiology for clubfoot and supply a mechanistic framework to grasp clubfoot in people.
Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models

Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal group.

Macrophages are innate immune cells that continually patrol an organism to meet protecting and homeostatic roles. Earlier research have proven that Rho GTPase exercise is required for macrophage mobility, but the roles of upstream regulatory proteins controlling Rho GTPase operate in these cells will not be effectively outlined.
Beforehand we’ve got proven that the RhoA GEF Net1 is required for human breast most cancers cell motility and extracellular matrix invasion. To evaluate the function of Net1 in macrophage motility, we remoted bone marrow macrophage (BMM) precursors from wild kind and Net1 knockout mice.
Lack of Net1 didn’t have an effect on the power of BMM precursors to distinguish into mature macrophages in vitro, as measured by CD68 and F4/80 staining. Nevertheless, Net1 deletion considerably lowered RhoA activation, F-actin accumulation, adhesion, and motility in these cells.
Nonetheless, just like RhoA/RhoB double knockout macrophages, Net1 deletion didn’t impair macrophage recruitment to the peritoneum in a mouse mannequin of sterile irritation. These information show that Net1 is a vital regulator of RhoA signaling and motility in mouse macrophages in vitro, however that its operate could also be dispensable for macrophage recruitment to inflammatory websites in vivo.

In Niemann-Decide C1 mouse fashions, glial-only expression of the traditional gene extends survival a lot additional than do modifications in genetic background or therapy with hydroxypropyl-beta-cyclodextrin.

The Npc1nmf164 allele of Npc1 gives a mouse mannequin for Niemann-Decide illness kind C1 (NPC1), a genetic illness identified to have a extensively variable phenotype.
The switch of the Npc1nmf164 mutation from the C57BL/6J inbred pressure to the BALB/cJ inbred pressure elevated the imply lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background.
The switch of one other Npc1 allele, Npc1nih, to this background additionally prolonged survival of the homozygotes indicating that the modifying impact of BALB/cJ isn’t restricted to a single allele of Npc1. The elevated longevity because of the BALB/cJ background didn’t map to a beforehand mapped modifier on chromosome 19, indicating the presence of extra genes impacting illness severity.
The beforehand studied Glial Fibrillary Acidic Protein promoter-Npc1 cDNA transgene (GFAP-Npc1) which solely expresses NPC1 in astrocytes additional prolonged the lifespan of Npc1nmf164 homozygotes on a BALB/cJ background (as much as 600days). Hydroxypropyl-β-cyclodextrin (HPβCD) therapy, not beforehand examined within the Npc1nmf164 mutant, prolonged life within the Npc1nmf164 homozygotes however not the transgenic, Npc1nmf164 mice on the BALB/cJ background.

MOUSE ANTI HUMAN PODOPLANIN

MBS212743-5x01mg 5x0.1mg
EUR 1840

Hamster anti Podoplanin (mouse)

103-M40 100ug
EUR 297.6

Mouse Anti-Human Podoplanin

MBS690117-0025mg 0.025mg
EUR 310

Mouse Anti-Human Podoplanin

MBS690117-5x0025mg 5x0.025mg
EUR 1110

Mouse Anti-Human Podoplanin

MBS690586-01mg 0.1mg
EUR 450

Mouse Anti-Human Podoplanin

MBS690586-5x01mg 5x0.1mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS690680-0025mg 0.025mg
EUR 310

Mouse Anti-Human Podoplanin

MBS690680-5x0025mg 5x0.025mg
EUR 1110

Mouse Anti-Human Podoplanin

MBS690759-01mg 0.1mg
EUR 450

Mouse Anti-Human Podoplanin

MBS690759-5x01mg 5x0.1mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS690992-005mg 0.05mg
EUR 430

Mouse Anti-Human Podoplanin

MBS690992-5x005mg 5x0.05mg
EUR 1645

Mouse Anti-Human Podoplanin

MBS692357-005mg 0.05mg
EUR 450

Mouse Anti-Human Podoplanin

MBS692357-5x005mg 5x0.05mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS692358-005mg 0.05mg
EUR 450

Mouse Anti-Human Podoplanin

MBS692358-5x005mg 5x0.05mg
EUR 1725

Mouse anti Podoplanin-Biotin (human)

101-MBi40 50ug
EUR 297.6

Hamster anti Podoplanin-Biotin (mouse)

103-MBi40 50ug
EUR 297.6

Podoplanin Mouse mAb

A18776 100μL
EUR 719.13

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-0005mg 0.005mg
EUR 240

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-002mg 0.02mg
EUR 310

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-01mg 0.1mg
EUR 610

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-5x01mg 5x0.1mg
EUR 2405

Mouse Podoplanin, soluble

MBS691731-0005mg 0.005mg
EUR 250

Mouse Podoplanin, soluble

MBS691731-5x0005mg 5x0.005mg
EUR 835

Anti-Human/Mouse PDPN/Podoplanin Antibody

MBS1569238-01mg 0.1mg
EUR 405

Anti-Human/Mouse PDPN/Podoplanin Antibody

MBS1569238-5x01mg 5x0.1mg
EUR 1520

Recombinant Mouse Podoplanin

MBS7610672-005mg 0.05mg
EUR 345

Recombinant Mouse Podoplanin

MBS7610672-02mg 0.2mg
EUR 635

Recombinant Mouse Podoplanin

MBS7610672-1mg 1mg
EUR 1800

Recombinant Mouse Podoplanin

MBS7610672-5x1mg 5x1mg
EUR 6955

Mouse Monoclonal anti-Rat Podoplanin Antibody

xAP-0897 100ug
EUR 280

Mouse Podoplanin ELISA kit

E01A24381 96T
EUR 700
Description: ELISA

Mouse Podoplanin ELISA kit

E03P0082-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA Kit

IMSPDPNKT each
EUR 752
Description: Mouse Podoplanin ELISA Kit

Mouse Podoplanin ELISA Kit

MBS725552-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Podoplanin ELISA Kit

MBS725552-48StripWells 48-Strip-Wells
EUR 485

Mouse Podoplanin ELISA Kit

MBS725552-5x96StripWells 5x96-Strip-Wells
EUR 3020

Mouse Podoplanin ELISA Kit

MBS725552-96StripWells 96-Strip-Wells
EUR 690

Mouse Podoplanin ELISA Kit

MBS2884556-10x96StripWells 10x96-Strip-Wells
EUR 4080

Mouse Podoplanin ELISA Kit

MBS2884556-48StripWells 48-Strip-Wells
EUR 390

Mouse Podoplanin ELISA Kit

MBS2884556-5x96StripWells 5x96-Strip-Wells
EUR 2220

Mouse Podoplanin ELISA Kit

MBS2884556-96StripWells 96-Strip-Wells
EUR 520

Hamster Anti-Mouse Podoplanin

MBS690646-01mg 0.1mg
EUR 450

Hamster Anti-Mouse Podoplanin

MBS690646-5x01mg 5x0.1mg
EUR 1725

Hamster Anti-Mouse Podoplanin

MBS690790-005mg 0.05mg
EUR 430

Hamster Anti-Mouse Podoplanin

MBS690790-5x005mg 5x0.05mg
EUR 1645

Anti-Mouse Podoplanin Antibody

103-M552 100 µg
EUR 399
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Mouse Podoplanin Antibody

103-PA40 200 µg
EUR 204.75
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Mouse Podoplanin Antibody

103-PA40S 100 µg
EUR 126
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Mouse Podoplanin (PDPN) Protein

20-abx650139
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Podoplanin (PDPN) Protein

abx694266-10nmol 10 nmol
EUR 700

Mouse Podoplanin (PDPN) Protein

abx694266-5nmol 5 nmol
EUR 462.5

Mouse Podoplanin (PDPN) Protein

abx650139-100g 100 µg
EUR 537.5

Mouse Podoplanin (PDPN) Protein

abx650139-10g 10 µg
EUR 212.5

Mouse Podoplanin (PDPN) Protein

abx650139-50g 50 µg
EUR 375

Mouse Monoclonal Podoplanin Antibody

TA327727 1 ml Ask for price

anti- Podoplanin antibody

FNab06598 100µg
EUR 702
Description: Antibody raised against Podoplanin

anti- Podoplanin antibody

FNab06599 100µg
EUR 702
Description: Antibody raised against Podoplanin

Mouse Podoplanin (PDPN) CLIA Kit

20-abx493858
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  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

abx571749-96tests 96 tests
EUR 943.2

Mouse Podoplanin (PDPN) ELISA Kit

20-abx154564
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  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu 96T
EUR 475
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DL-PDPN-Mu 96T
EUR 453
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

EK8596 96Т
EUR 799

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-48T 48T
EUR 389.62

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-5x96T 5x96T
EUR 2643.85

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-96T 96T
EUR 556.6

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN)ELISA kit

YLA0596MO-48T 48T Ask for price

Mouse Podoplanin (PDPN)ELISA kit

YLA0596MO-96T 96T Ask for price

Mouse Podoplanin, Pdpn ELISA KIT

ELI-06723m 96tests
EUR 736

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-1096T 10*96T
EUR 4122

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-48wells 48 wells
EUR 300

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-596T 5*96T
EUR 2061

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-96wells 96 wells
EUR 458

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-48T 48T
EUR 571.55

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-5x96T 5x96T
EUR 3878.38

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-96T 96T
EUR 816.5

Mouse Podoplanin(PDPN)ELISA kit

QY-E21215 96T
EUR 433.2

Mouse Podoplanin (PDPN) ELISA Kit

RK13459 96T
EUR 280

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-48T 48T
EUR 487.52
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-48Tests 48 Tests
EUR 668.4

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-96T 96T
EUR 696.47
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-96Tests 96 Tests
EUR 928.8

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-48T 48T
EUR 464.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-48Tests 48 Tests
EUR 639.6

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-96T 96T
EUR 663.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-96Tests 96 Tests
EUR 888

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

4-SEC719Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-48T 48T
EUR 325
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-96T 96T
EUR 610
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-48StripWells 48-Strip-Wells
EUR 550

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-96StripWells 96-Strip-Wells
EUR 765

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-48StripWells 48-Strip-Wells
EUR 305

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-96StripWells 96-Strip-Wells
EUR 475

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-10x96StripWells 10x96-Strip-Wells
EUR 5455

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-24StripWells 24-Strip-Wells
EUR 365

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-48StripWells 48-Strip-Wells
EUR 550

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-5x96StripWells 5x96-Strip-Wells
EUR 2985

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-96StripWells 96-Strip-Wells
EUR 740

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-10x96Tests 10x96Tests
EUR 5375

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-48Tests 48Tests
EUR 470

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-5x96Tests 5x96Tests
EUR 2755

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-96Test 96Test
EUR 620

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-10x96StripWells 10x96-Strip-Wells
EUR 6255

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-48StripWells 48-Strip-Wells
EUR 445

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-5x96StripWells 5x96-Strip-Wells
EUR 3290

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-96StripWells 96-Strip-Wells
EUR 730

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-10x96StripWells 10x96-Strip-Wells
EUR 5160

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-48StripWells 48-Strip-Wells
EUR 450

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-5x96StripWells 5x96-Strip-Wells
EUR 2645

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-96StripWells 96-Strip-Wells
EUR 595

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-10x96StripWells 10x96-Strip-Wells
EUR 3215

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-24StripWells 24-Strip-Wells
EUR 255

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-48StripWells 48-Strip-Wells
EUR 340

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-5x96StripWells 5x96-Strip-Wells
EUR 1675

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-96StripWells 96-Strip-Wells
EUR 430

Recombinant Mouse Podoplanin Protein

MBS8305318-001mg 0.01mg
EUR 220

Recombinant Mouse Podoplanin Protein

MBS8305318-005mg 0.05mg
EUR 450

Recombinant Mouse Podoplanin Protein

MBS8305318-05mg 0.5mg
EUR 1905

Recombinant Mouse Podoplanin Protein

MBS8305318-5x05mg 5x0.5mg
EUR 8485

Mouse PDPN (Podoplanin) ELISA Kit

EKE61859-5x96T 5x96T
EUR 3124.08

Mouse PDPN (Podoplanin) ELISA Kit

EKE61859-96T 96T
EUR 657.7

Mouse PDPN(Podoplanin) ELISA Kit

ELK7080-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PDPN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PDPN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PDPN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PDPN in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PDPN(Podoplanin) ELISA Kit

ELK7080-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PDPN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PDPN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PDPN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PDPN in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PDPN(Podoplanin) ELISA Kit

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Mouse PDPN (Podoplanin) ELISA Kit

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In all circumstances, lack of weight acquire and early cerebellar signs of lack of motor management have been discovered. At termination, the one mouse sacrificed for histological research confirmed extreme, diffuse pulmonary alveolar proteinosis suggesting that pulmonary abnormalities in NPC1 mouse fashions will not be distinctive to the Npc1nih allele.

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